Association Of Estimated Glucose Disposition Rate With Aging Acceleration And Mortality Risk In Individuals With Cardiovascular-Kidney-Metabolic Syndrome: Evidence From Two Large National Population-Based Studies
Our bodies have an incredible way of managing sugar, and how efficiently they do this can impact our health in profound ways. A new study sheds light on this by examining a measurement called the estimated glucose disposal rate (eGDR), which essentially reflects how well your body processes sugar, or its insulin sensitivity. The research focused on individuals with a complex condition known as cardiovascular-kidney-metabolic (CKM) syndrome, a group of interconnected health problems affecting the heart, kidneys, and metabolism.
The study explored the relationship between eGDR, how quickly a person’s body is aging biologically (referred to as aging acceleration), and their risk of mortality. Aging acceleration means that a person’s biological age appears older than their actual chronological age. By analyzing data from two large national population-based studies, researchers found that a lower eGDR was associated with both accelerated aging and an increased risk of death in people with CKM syndrome. Interestingly, a portion of this increased mortality risk linked to lower eGDR could be explained by the observed acceleration in aging. These findings suggest that eGDR could be a valuable indicator for predicting health outcomes and a potential target for interventions aimed at slowing down the aging process and reducing mortality risk in those living with CKM syndrome.