Aging Research News Feed

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A Unified Framework For Systematic Curation And Evaluation Of Aging Biomarkers

Clock
Analytical

Researchers developed an open-source framework called Biolearn to standardize the evaluation of aging biomarkers, revealing that different biomarkers are optimal for predicting chronological age versus mortality and healthspan.

Nov 16, 2025
Gemini
 

A Versatile Cohesion Manipulation System Probes Female Reproductive Age-Related Egg Aneuploidy

Aging Theory
Aging Pathway

Researchers developed a system to precisely control chromosome cohesion in mouse eggs, revealing that premature chromosome separation, a cause of age-related infertility, dramatically increases only when cohesion proteins fall below a critical level.

Nov 16, 2025
Gemini
 

Aging Represses Oncogenic KRAS-Driven Lung Tumorigenesis And Alters Tumor Suppression

Aging Theory
Aging Pathway
Analytical

Aging can suppress the initiation and growth of lung tumors driven by the oncogenic KRAS gene and alters the effectiveness of tumor suppression.

Nov 16, 2025
Gemini
 

Altered Nicotinamide Adenine Dinucleotide Metabolism Drives Cartilage Degeneration And Osteoarthritis

Aging Pathway
Therapeutic

A decline in a vital molecule called NAD+ due to increased consumption by an enzyme named PARP14 contributes to cartilage breakdown and the development of osteoarthritis.

Nov 16, 2025
Gemini
 

Chemical Modulation Of Gut Bacterial Metabolism Induces Colanic Acid And Extends The Lifespan Of Nematode And Mammalian Hosts

Aging Pathway
Therapeutic

A chemical approach that modulates gut bacterial metabolism to produce colanic acid has been shown to extend the lifespan of nematode and mammalian hosts.

Nov 16, 2025
Gemini
 

Computational Strategies For Exploring Amino Acids And Peptides As Inhibitors Of Advanced Glycation Endproducts

Therapeutic
Analytical

Computational methods are being utilized to identify and design amino acids and peptides that can inhibit the formation of Advanced Glycation Endproducts (AGEs), which are toxic compounds implicated in various diseases.

Nov 16, 2025
Gemini
 

Dental Ageing Offers New Insights Into The First Epigenetic Clock For Common Dolphins (Delphinus Delphis)

Clock
Analytical

Researchers have developed the first DNA-based “epigenetic clock” for common dolphins, enabling accurate age estimation from skin samples, even from deceased animals, which is vital for conservation efforts.

Nov 16, 2025
Gemini
 

Divergent Effects Of Cytomegalovirus And Rheumatoid Arthritis On Senescent Cd4+ T Cells

Cytomegalovirus infection leads to an increase in aged CD4+ T cells with a cell-killing function, while rheumatoid arthritis primarily impairs the function of these aged cells, especially in individuals also infected with cytomegalovirus.

Nov 16, 2025
Gemini
 

Injectable Glycyrrhizic Acid Hydrogel Microspheres With Synergistic Anti-Senescence And Osteogenic Effects For Osteoporosis Therapy

Therapeutic
Aging Pathway

Researchers developed injectable hydrogel microspheres containing glycyrrhizic acid that effectively promoted bone formation and reduced cellular aging in a mouse model of osteoporosis.

Nov 16, 2025
Gemini
 

Integrated Multiomics Analysis And Mendelian Randomization Identify Sirt1 As A Pivotal Aging-Associated Gene In Meningioma

Analytical
Aging Pathway
Therapeutic

A recent study identified SIRT1 as a key gene linking aging to the development of meningiomas, suggesting it could be a target for diagnosis and treatment.

Nov 16, 2025
Gemini
 

Long-Read Sequencing Reveals Genomic And Epigenomic Variation In The Dark Genome Of Human Alzheimer’S Disease

Long-read sequencing has revealed significant genomic and epigenomic changes within the previously unexamined “dark genome” regions of human brains affected by Alzheimer’s disease.

Nov 16, 2025
Gemini
 

Longevity Code: Lipidome Associations And Mediated Metabolite Effects

Aging Pathway

Specific types of fats (lipids) and small molecules (metabolites) in the body have been found to causally influence an individual’s genetic predisposition to longevity.

Nov 16, 2025
Gemini
 

Redox Homeostasis In Ferroptosis And Aging: A Causal Role For Fard-1 And Dhs-25 In Caenorhabditis Elegans

Aging Pathway

The study reveals a causal link between ferroptosis, a specific type of iron-dependent cell death, and the process of physiological aging, demonstrating that this connection is mediated by an imbalance in the body’s natural antioxidant systems in the model organism Caenorhabditis elegans.

Nov 16, 2025
Gemini
 

Sphingolipid And Methionine Metabolism In Aging

Aging Theory
Aging Pathway

This review explores the intricate relationship between sphingolipid metabolism, organelle function, and methionine restriction in the context of aging.

Nov 16, 2025
Gemini
 

A Computational Investigation Of Small Peptide Of Methyl Jasmonate And Human Complement Factor In Ageing

Analytical
Therapeutic

A computational study revealed that a small peptide derived from wine grapes interacts with a human protein, Complement Factor H, suggesting a potential role in anti-aging mechanisms.

Nov 13, 2025
Gemini
 

A Novel Polypeptide Inhibitor Of MMP-1 Attenuates The UVA-Mediated Skin Aging

Therapeutic
Aging Pathway

A newly developed polypeptide inhibitor effectively reduces UVA-induced skin aging by targeting a key enzyme, improving skin firmness and reducing wrinkles.

Nov 13, 2025
Gemini
 

Age Differences In Spontaneous Cerebrovascular Reactivity At Rest

Aging Pathway

Older adults, even those without cognitive impairment, exhibit reduced spontaneous cerebrovascular reactivity at rest compared to younger adults, especially in brain regions like the medial temporal lobe.

Nov 13, 2025
Gemini
 

An Fmri Approach To Assess Intracranial Arterial-To-Venous Cardiac Pulse Delay In Aging

Analytical

A new method using functional MRI can measure the delay between arterial and venous pulsations in the brain, revealing that this delay shortens with age and is faster in men compared to women.

Nov 13, 2025
Gemini
 

Association Between Biological Aging And Genetic Susceptibility With The Risk Of Bipolar Disorder And Schizophrenia: A Prospective Cohort Study

Analytical

Accelerated biological aging is significantly associated with an increased risk of developing bipolar disorder and schizophrenia, with an even higher risk observed when combined with a strong genetic predisposition.

Nov 13, 2025
Gemini
 

Association Between Home Environment Characteristics, Indoor Dust Microbiota And Frailty Among Community-Dwelling Older Adult Couples

Lever

Certain home environment factors, including specific temperature ranges and the makeup of indoor dust microbes, are linked to frailty in older adult couples.

Nov 13, 2025
Gemini
 

Association Of Biological Age Acceleration With Mortality In Adults With Diabetes Or Prediabetes: A Mediating Role Of Physical Activity

Clock
Lever

Adults with diabetes or prediabetes who experience accelerated biological aging face a higher risk of mortality, a risk that is partially mitigated by engaging in higher levels of physical activity.

Nov 13, 2025
Gemini
 

Bridging Social Isolation, Loneliness, And Brain Aging: A Narrative Review Of Mechanisms And Translational Interventions

Aging Pathway
Lever

Social isolation and loneliness are significant factors contributing to accelerated brain aging and cognitive decline, operating through a self-reinforcing cycle involving interconnected brain networks and molecular mechanisms.

Nov 13, 2025
Gemini
 

Clonal Hematopoiesis Of Indeterminate Potential: A Review Of Its Cardiorenal Implications And Aging

Aging Pathway

Clonal hematopoiesis of indeterminate potential (CHIP), an age-related condition characterized by acquired mutations in blood stem cells, is linked to an increased risk of developing cardiovascular and kidney diseases.

Nov 13, 2025
Gemini
 

Combination Antiretroviral Therapy Prevents SIV-Induced Aging In The Hippocampus And Neurodegeneration Throughout The Brain

Therapeutic
Aging Pathway

Combination antiretroviral therapy effectively reverses accelerated brain aging and reduces nerve cell damage caused by simian immunodeficiency virus infection.

Nov 13, 2025
Gemini
 

Decoding Noncoding Rnas In Regulating Cardiovascular Aging And Age-Related Conditions: The Emerging Landscape

Aging Pathway

Non-coding RNAs, including microRNAs, long non-coding RNAs, and circular RNAs, play a crucial role in regulating cardiovascular aging and associated diseases by influencing both pro-aging and anti-aging processes.

Nov 13, 2025
Gemini
 

Defective Chaperone-Mediated Autophagy In The Retinal Pigment Epithelium Of Age-Related Macular Degeneration Patients

Aging Pathway
Therapeutic

A specific cellular cleaning process called chaperone-mediated autophagy is found to be defective in the retinal pigment epithelium of patients with age-related macular degeneration, contributing to the disease.

Nov 13, 2025
Gemini
 

Diagnostic Accuracy Of Sarcopenia Screening Tools In Low-Income Older Adults In Amazonas, Brazil

Analytical

The Ishii test demonstrated the highest diagnostic accuracy for sarcopenia in low-income older adults in the Amazonas region of Brazil.

Nov 13, 2025
Gemini
 

Dissociation Of The Nuclear Basket Triggers Chromosome Loss In Aging Yeast

Aging Pathway

Aging in yeast causes the nuclear basket to detach from the nuclear pore complex, leading to the asymmetric distribution and loss of chromosomes, a process linked to the leakage of unprocessed genetic material.

Nov 13, 2025
Gemini
 

Effects Of Protein-Based Multinutrient Therapy On Sarcopenia In Older Adults: A Systematic Review And Meta-Analysis

Therapeutic
Lever
Analytical

Protein-based multinutrient therapy significantly improved handgrip strength, gait speed, and Insulin-like Growth Factor-1 levels in older adults with sarcopenia.

Nov 13, 2025
Gemini
 

Estrogen Depletion And Immune Activation And Inflammation In Women With HIV

Aging Pathway

Estrogen depletion during menopause in women with HIV alters immune responses, leading to chronic inflammation, increased risk of other health conditions, and the persistence of the HIV reservoir.

Nov 13, 2025
Gemini
 

Evaluation And Research Progress On Rodent Models Of Late-Onset Hypogonadism: A Comprehensive Review

Aging Pathway

A comprehensive review summarizes and analyzes the characteristics, methods, and evaluation systems of various rodent models used in late-onset hypogonadism research to guide optimal model selection and development.

Nov 13, 2025
Gemini
 

Evaluation And Research Progress On Rodent Models Of Late-Onset Hypogonadism: A Comprehensive Review

Aging Pathway

This comprehensive review synthesizes the characteristics, methodologies, and assessment criteria of various rodent models employed in the study of late-onset hypogonadism, critically evaluating their strengths and weaknesses to inform optimal model selection for future research.

Nov 13, 2025
Gemini
 

Exercise Attenuates Inflammaging And Testosterone Decline In Aged And Morphine-Treated Rats: A Role For NF-Κb Signaling

Aging Pathway
Lever

Regular exercise can reduce age-related inflammation and testosterone decline, even in the presence of morphine, by influencing a specific cellular signaling pathway.

Nov 13, 2025
Gemini
 

Exercise Intensity Influences Body Composition: A 6-Month Comparison Of High-Intensity Interval, Moderate- And Low-Intensity Training Among Healthy Older Adults

Lever

A 6-month study found that high-intensity exercise effectively reduced body fat and preserved muscle mass in healthy older adults, while moderate-intensity exercise also reduced fat but led to some loss of muscle.

Nov 13, 2025
Gemini
 

Exploring A Crossroads In The Aging Process

Aging Pathway

Experiments on yeast reveal that the nuclear pore complex plays a central role in the age-related loss of chromosomes.

Nov 13, 2025
Gemini
 

Exploring Senescence Markers As Potential Drivers Of Osteoarthritis Pain In Aging Adults

Aging Pathway

The paper suggests that senescent cells and the inflammatory molecules they release play a significant role in driving osteoarthritis pain in older adults.

Nov 13, 2025
Gemini
 

Exploring The Effects Of A Multicomponent Phytoceutical Health Product In A Drosophila Melanogaster Ageing And Repetitive Concussion Model

Therapeutic

A natural health product, CONKA1, was found to improve lifespan, motor activity, and reduce cellular damage from oxidative stress in fruit flies, even when subjected to repetitive concussions.

Nov 13, 2025
Gemini
 

Factors Associated With Frailty Transitions Using The Kihon Checklist: A 6-Year Longitudinal Study Among Japanese Residents

Analytical
Lever

A long-term study revealed specific social, physical, and cognitive factors that determine whether older Japanese adults remain healthy, become more vulnerable, or recover from frailty.

Nov 13, 2025
Gemini
 

Factors Associated With Risk Of Clonal Haematopoiesis Of Indeterminate Potential: A Systematic Review And Meta-Analysis

Analytical

A systematic review and meta-analysis found that hypertension, HIV infection, and smoking are linked to an increased risk of Clonal Haematopoiesis of Indeterminate Potential (CHIP), while Asian ethnicity is associated with a lower risk, with these associations varying by specific gene mutations.

Nov 13, 2025
Gemini
 

Frailty Modulates The Predictive Value Of Performance Status In Older Adults Living With Cancer

Analytical

Frailty significantly alters how well a patient’s performance status predicts their outcome in older adults living with cancer, making traditional performance status tools less reliable for frail individuals.

Nov 13, 2025
Gemini
 

GLP-1R Agonists And Muscle Health: Potential Role In Sarcopenia Prevention And Treatment

Therapeutic
Aging Pathway

GLP-1 receptor agonists, commonly used for weight loss and diabetes, have shown promising muscle-preserving effects in preclinical studies, but clinical trials indicate a concern regarding the loss of lean muscle mass alongside fat loss, particularly in vulnerable populations.

Nov 13, 2025
Gemini
 

Identification And Molecular Mechanisms Of Novel Antioxidant Peptides From Manila Clam Hydrolysate: Caenorhabditis Elegans Model, Molecular Simulations, And Quantum Chemistry

Therapeutic
Aging Pathway

Researchers have identified novel antioxidant peptides from Manila clam hydrolysates that exhibit significant antioxidant activity, prolong the lifespan of Caenorhabditis elegans, and protect human cells from oxidative stress.

Nov 13, 2025
Gemini
 

Integrative Omics Reveal Female-Specific Benefits Of P16+ Cell Clearance In Aging Mice

Aging Pathway
Therapeutic

Clearing specific aging cells, known as p16+ cells, primarily benefits female mice by improving their physical health, regenerating skin, and reducing liver damage.

Nov 13, 2025
Gemini
 

Lights For Aging: Can Photobiomodulation Restore Functionality In The Cerebral Networks Of Aged Individuals?

Therapeutic

The paper suggests that using red and near-infrared light, known as photobiomodulation, may help to slow brain aging, reduce inflammation, and improve overall brain function and quality of life in older adults.

Nov 13, 2025
Gemini
 

N-Acetylcarnosine Attenuates Age-Associated Declines In Multi-Organ Systems To Improve Survival

Therapeutic

A six-month treatment with N-acetylcarnosine significantly reduced various age-related health issues and extended the lifespan of female mice by approximately 50%.

Nov 13, 2025
Gemini
 

Neuronal Pentraxin 1 Accelerates Post-Stroke Atherosclerosis By Inducing Endothelial Cell Senescence

Aging Pathway
Therapeutic

A protein called neuronal pentraxin 1 (NPTX1) increases after a stroke and speeds up the development of atherosclerosis, a condition where arteries harden, by causing the cells lining blood vessels to age prematurely.

Nov 13, 2025
Gemini
 

Polyamine Treatment In Elderly Patients With Coronary Artery Disease (POLYCAD): Study Protocol For A Danish Randomised, Double-Blind, Placebo-Controlled Trial Of Spermidine Treatment Versus Placebo

Therapeutic

A Danish randomized, double-blind, placebo-controlled trial is investigating whether daily spermidine treatment can improve heart health, physical fitness, muscle mass, and reduce inflammation in elderly patients with Coronary Artery Disease.

Nov 13, 2025
Gemini
 

Ppp1R3G Inhibition Impairs Opcs Differentiation And Myelination In Aged Mice

Aging Pathway
Therapeutic

A protein called PPP1R3G is crucial for maintaining the brain’s white matter and cognitive function in aging, and its decline contributes to age-related cognitive impairment.

Nov 13, 2025
Gemini
 

Preventive Effect Of Fisetin On Follicular Granulosa Cells Senescence Via Attenuating Oxidative Stress And Upregulating The Wnt/Β-Catenin Signaling Pathway

Therapeutic
Aging Pathway

Fisetin, a natural compound, has been found to prevent the aging of ovarian cells by reducing cellular damage and improving cell growth processes, potentially safeguarding egg production.

Nov 13, 2025
Gemini
 

Preventive Effect Of Fisetin On Follicular Granulosa Cells Senescence Via Attenuating Oxidative Stress And Upregulating The Wnt/Β-Catenin Signaling Pathway

Therapeutic
Aging Pathway

Fisetin, a natural compound, has been found to prevent the aging of ovarian cells by reducing cellular stress and improving cell function, potentially benefiting egg production in aging animals.

Nov 13, 2025
Gemini
 

Revisiting The Relationship Between Cardiorespiratory Fitness And Biological Aging: Insights From Dunedinpace Analysis

Clock
Lever

Higher cardiorespiratory fitness is associated with a slower pace of biological aging, and a specific fitness threshold was identified that differentiates individuals with slower biological aging.

Nov 13, 2025
Gemini
 

Sex And APOE Ε2 Interactive Effects On The Longitudinal Change In Cognition In A Population-Based Cohort Of Older Adults With Vascular Risk Factors

Aging Pathway
Analytical

The APOE ε2 genetic variant may negatively impact verbal memory in aging men and does not consistently protect against cognitive decline over time.

Nov 13, 2025
Gemini
 

Sex And APOE Ε2 Interactive Effects On The Longitudinal Change In Cognition In A Population-Based Cohort Of Older Adults With Vascular Risk Factors

Aging Pathway

A study on older adults with vascular risk factors found that the APOE ε2 gene, often considered protective, may surprisingly be linked to a decline in verbal memory in aging males, while not providing a consistent protective effect for females.

Nov 13, 2025
Gemini
 

Sex Differences In The Associations Among Grip Strength, Walking Speed, Sarcopenic Obesity, And Mild Cognitive Impairment: Evidence From The Qingdao (Laoshan) Aging And Cognition Screening (QLACS) Project

Analytical

The study revealed that the relationships between physical indicators like grip strength, walking speed, and sarcopenic obesity, and the risk of mild cognitive impairment, differ significantly between men and women.

Nov 13, 2025
Gemini
 

Sirt1/PGC-1Α/Mfn2 Pathway Regulates Mitochondrial Homeostasis In VSMC To Attenuate Aging-Related Vascular Calcification

Aging Pathway

This research reveals that a specific cellular pathway involving SIRT1, PGC-1α, and Mfn2 is essential for maintaining healthy mitochondria in blood vessel cells, and enhancing this pathway can reduce the hardening of arteries associated with aging.

Nov 13, 2025
Gemini
 

The Association Between CKD And Frailty In The FRASNET Study: Suggestion Of A Novel Egfr Threshold As A Key Determinant Of Frailty In The Elderly

Analytical

The study identified a new estimated glomerular filtration rate (eGFR) threshold of 53.5 ml/min/1.73 m2 that is significantly associated with frailty in older adults, suggesting a critical level of kidney function for maintaining physical resilience.

Nov 13, 2025
Gemini
 

The Association Between Divorce And Late-Life Brain Health In A Racially And Ethnically Diverse Cohort Of Older Adults

Lever

A study on a diverse group of older adults indicated that a history of divorce was not significantly linked to late-life brain health outcomes, including brain volume and white matter changes.

Nov 13, 2025
Gemini
 

The Influence Of Structured Physical Activity On Vaccination Response From Adults To Older Individuals: A Systematic Review On The Immunoinflammatory Crosstalk Of COVID-19

Lever

Regular structured physical activity can improve the body’s immune response to COVID-19 vaccination and reduce inflammation in adults and older individuals.

Nov 13, 2025
Gemini
 

The Interplay Between Genotoxic Stress And STING Activation In Cellular Senescence And Inflammatory Responses

Aging Pathway

The paper reveals that DNA damage, or genotoxic stress, activates a cellular pathway called STING, which then drives cellular aging and inflammatory responses.

Nov 13, 2025
Gemini
 

The Mediating Role Of Biological Age In The Impact Of Mood Instability Symptoms On Neurodegenerative Disease And Mortality

Clock
Analytical

Severe mood instability symptoms are linked to an increased risk of neurodegenerative diseases and mortality, with accelerated biological aging playing a partial role in this connection.

Nov 13, 2025
Gemini
 

The Role Of The Sirt1 And Mtor Pathways In Exercise-Induced Β-Cell Senescence Reduction In Type 2 Diabetes Mellitus

Aging Pathway
Lever
Therapeutic

Exercise helps reduce the aging and dysfunction of insulin-producing cells in individuals with type 2 diabetes by activating the SIRT1 pathway and inhibiting the mTOR pathway.

Nov 13, 2025
Gemini
 

Accelerated Regeneration Of Senescent Bone Injury Through Age- And Sex-Independent Macrophage Polarization

Therapeutic
Aging Pathway

A new therapeutic strategy using phosphatidylserine liposomes has been shown to accelerate bone regeneration in senescent bone injuries by promoting a pro-healing macrophage response, regardless of the age or sex of the individual.

Nov 12, 2025
Gemini
 

Allicin Attenuates Age-Related Cognitive And Neural Decline In A Rat Model By Modulating Amyloid Burden And Regulating BDNF/Nrf2 Gene Expression

Therapeutic
Aging Pathway

Allicin, a compound found in garlic, has been shown to reduce age-related cognitive and neural decline in a rat model by decreasing amyloid protein accumulation and regulating gene expression related to brain health.

Nov 12, 2025
Gemini
 

Association Between Blood Nicotinamide Adenine Dinucleotide Levels And Blood Laboratory Parameters At Baseline And After Nicotinamide Mononucleotide Supplementation In Middle-Aged Healthy Individuals: Post Hoc Analysis Of A Randomized, Double-Blinded, Placebo-Controlled Clinical Trial

Therapeutic

Supplementation with nicotinamide mononucleotide (NMN) was found to increase blood nicotinamide adenine dinucleotide (NAD) levels, which in turn was associated with improvements in red blood cell parameters in middle-aged healthy individuals.

Nov 12, 2025
Gemini
 

Autophagy-Senescence Interplay In Kidney Disease: Mechanistic Insights And Therapeutic Potential

Aging Pathway
Therapeutic

The intricate relationship between cellular self-cleaning processes and cellular aging plays a significant role in the development and progression of kidney diseases, offering new avenues for therapeutic interventions.

Nov 12, 2025
Gemini
 

Cardiovascular And Peripheral Factors Affecting The Decay Of Maximal Oxygen Uptake Across The Spectrum Of Age In Humans

Analytical

The progressive increase in the resistance of peripheral tissues to oxygen uptake significantly contributes to the age-related decline in maximal oxygen uptake, potentially more than the decrease in the heart’s ability to transport oxygen.

Nov 12, 2025
Gemini
 

Chaperone-Mediated Autophagy Controls Brown Adipose Tissue Thermogenic Activity

Aging Pathway
Therapeutic

A cellular recycling process called chaperone-mediated autophagy is essential for brown fat to generate heat, particularly as the body ages, by breaking down proteins that suppress this heat-producing activity.

Nov 12, 2025
Gemini
 

Correction: Machine Learning Approach For Frailty Detection In Long-Term Care Using Accelerometer-Measured Gait And Daily Physical Activity: Model Development And Validation Study

Analytical

Machine learning models can identify frailty in older adults in long-term care settings by analyzing their walking patterns and daily physical activity, with a correction clarifying that frail individuals exhibit lower gait symmetry scores, indicating more asymmetrical walking.

Nov 12, 2025
Gemini
 

Dietary Iron Attenuates Epigenetic Aging Through DNA Methylation Remodeling And Extends Survival In Older Adults

Clock
Lever

Higher dietary iron intake is associated with favorable epigenetic profiles related to aging and a reduced risk of death from various causes in older adults.

Nov 12, 2025
Gemini
 

Distinct Senotypes In P16- And P21-Positive Cells Across Human And Mouse Aging Tissues

Aging Pathway
Analytical

Cells marked by p16 and p21, both indicators of cellular aging, represent largely distinct populations with different characteristics and contributions to aging across various human and mouse tissues.

Nov 12, 2025
Gemini
 

Elevated Alpha-1 Antitrypsin And C-Reactive Protein: Association On All-Cause And Cause-Specific Mortality In Older Adults

Analytical

Elevated levels of alpha-1 antitrypsin, an inflammation-regulating protein, are a strong independent predictor of overall mortality in older adults, with an even greater risk when combined with high levels of C-reactive protein, another inflammation marker.

Nov 12, 2025
Gemini
 

Epigenetic Dysregulation In Aged Muscle Stem Cells Drives Mesenchymal Progenitor Expansion Via IL-6 And Spp1 Signaling

Aging Pathway
Therapeutic

Aged muscle stem cells independently drive the expansion of fibro-adipogenic progenitors and promote muscle scarring through specific epigenetic changes and signaling pathways.

Nov 12, 2025
Gemini
 

Immune-Mediated Interactions Between Sarcopenia And Atherosclerosis In Aging

Aging Pathway
Therapeutic

Sarcopenia, an age-related loss of muscle mass, and atherosclerosis, the hardening of arteries, are interconnected by shared immune system pathways, particularly chronic inflammation associated with aging.

Nov 12, 2025
Gemini
 

Impact Of Histone Post-Translational Modification Inhibitors On Lifespan, Reproduction, And Stress Response In The Rotifer Brachionus Manjavacas

Aging Pathway
Therapeutic

Inhibiting specific histone modifications in the rotifer Brachionus manjavacas can extend lifespan and improve stress resistance without negatively affecting reproduction.

Nov 12, 2025
Gemini
 

Intracellular And Extracellular Redox Signals During Exercise And Aging

Aging Pathway
Lever

The paper reveals that reactive oxygen species act as critical signals within and between cells, influencing how muscles adapt to exercise and aging, thereby impacting muscle function and metabolic health.

Nov 12, 2025
Gemini
 

Ketotifen Reacidifies Secretory Lysosomes And Normalises Ageing Phenotypes In Mast Cells

Aging Pathway
Therapeutic

A recent study discovered that a common medication called ketotifen can restore the proper acidic environment within specialized compartments of immune cells called mast cells, thereby reversing certain age-related changes in these cells.

Nov 12, 2025
Gemini
 

KLOTHO-VS Heterozygosity, Α-KLOTHO Protein Levels And Cognitive Performance In Alzheimer’S Disease

Aging Pathway

Individuals with the KLOTHO-VS gene variant heterozygosity showed better memory performance, especially in those with early memory impairment and a specific genetic risk factor for Alzheimer’s disease.

Nov 12, 2025
Gemini
 

Longevity-Promoting Mitochondrial Unfolded Protein Response Activation Requires Elements Of The Pebow Complex

Aging Pathway

Reduced function of the VDAC-1 protein extends lifespan by activating a cellular stress response in mitochondria, a process that requires components of the PeBoW complex.

Nov 12, 2025
Gemini
 

Luteoloside Alleviates Bleomycin-Induced Pulmonary Fibrosis In Mice Via Sirt1-Mediated Protective Effect Against Alveolar Epithelial Cell Senescence

Therapeutic
Aging Pathway

Luteoloside, a compound found in plants, was shown to reduce lung scarring, oxidative stress, and cell aging in mice with bleomycin-induced pulmonary fibrosis, with its protective effects being mediated by a protein called SIRT1.

Nov 12, 2025
Gemini
 

Mechanopharmacology Of Cellular Microenvironment Stiffness: Therapeutic Strategies For Age-Related Diseases

Aging Pathway
Therapeutic

The paper highlights how increased stiffness in the cellular environment, a common change with aging, contributes to age-related diseases and explores strategies to target these mechanical changes for therapeutic benefit.

Nov 12, 2025
Gemini
 

Mesenchymal Stem Cell Derived Extracellular Vesicles Reverses Neural Aging Via OSKM Modulation

Therapeutic
Aging Pathway

MicroRNAs within extracellular vesicles derived from mesenchymal stem cells have been shown to reactivate aging cells by increasing specific transcription factors, suggesting a reversal of neural aging.

Nov 12, 2025
Gemini
 

Methodological Considerations Of Diet Assessment Of The Older Indian Population In The Longitudinal Aging Study In India-Harmonised Diagnostic Assessment Of Dementia (LASI-DAD)

Lever

The study successfully developed and implemented a comprehensive food frequency questionnaire for assessing the dietary intake of older Indian adults across diverse regions.

Nov 12, 2025
Gemini
 

Multi-Omic Profiling Reveals Age-Related Immune Dynamics In Healthy Adults

Aging Pathway
Analytical

A comprehensive study of healthy adults reveals that aging leads to specific changes in T cell gene activity, resulting in a T helper 2 cell bias that impairs B cell responses to vaccines.

Nov 12, 2025
Gemini
 

NMN Supplementation As A Strategy To Improve Oocyte Quality: A Systematic Review And Transcriptomic Analysis

Therapeutic
Aging Pathway
Analytical

NMN supplementation has been shown to improve egg cell quality by addressing mitochondrial dysfunction and NAD+ depletion, which are often associated with aging and metabolic stress.

Nov 12, 2025
Gemini
 

Premature Aging And Neuropathic Behaviours Induced By An Acute Low-Dose Exposure To A Sarin Surrogate

Aging Pathway

A single exposure to a low dose of a sarin-like chemical can lead to signs of premature aging and long-lasting nerve-related problems in mice.

Nov 12, 2025
Gemini
 

Protective And Reparative Effects Of Tremella Aurantialba Extract Against Skin Photoaging And Its Underlying Mechanisms

Therapeutic
Aging Pathway

An extract from the mushroom Tremella aurantialba demonstrates protective and reparative effects against skin aging caused by sun exposure by reducing oxidative stress, inflammation, and restoring skin barrier function and microbiota balance.

Nov 12, 2025
Gemini
 

Social Isolation And Cardiometabolic Burden Synergistically Predict Physical Dysfunction In Aging Chinese Adults: Evidence Of Risk Thresholds And The Mediating Role Of Frailty

Analytical

Social isolation and multiple cardiometabolic health problems together significantly increase the risk of physical decline in aging Chinese adults, with frailty acting as a key intermediate factor.

Nov 12, 2025
Gemini
 

A NADH Oxidase Nanozyme Restores Redox Homeostasis To Ameliorate Multi-Organ Aging And Ischemic Cardiomyopathy

Therapeutic
Aging Pathway

A vanadium-based nanozyme has been shown to restore the balance of critical molecules involved in cellular energy (redox homeostasis), thereby reducing signs of aging in multiple organs and improving heart function after a heart attack.

Nov 11, 2025
Gemini
 

Association Of Sarcopenia And Pancreatic Exocrine Insufficiency In Older Adults Type 2 Diabetes Mellitus Patients

Analytical

Pancreatic exocrine insufficiency may contribute to sarcopenia in older adult males with type 2 diabetes mellitus.

Nov 11, 2025
Gemini
 

Brain-Age Models With Lower Age Prediction Accuracy Have Higher Sensitivity For Disease Detection

Clock
Analytical

Brain-age models with lower accuracy in predicting chronological age demonstrate a higher ability to detect disease-related changes in the brain.

Nov 11, 2025
Gemini
 

Characteristics Of Peripheral Blood Lymphocyte Subsets In Elderly Patients With Psoriasis

Analytical

Elderly individuals with psoriasis exhibit specific changes in their immune cell populations, including a decrease in certain T cells and an increase in natural killer cells, with B cells showing potential as markers for disease severity.

Nov 11, 2025
Gemini
 

Comparative Evaluation Of Extraction Methods For Scorias Spongiosa Polysaccharides: Yield, Bioactivity, And Anti-Aging Potential

Therapeutic

The study compared different methods for extracting beneficial complex sugars from Scorias spongiosa, demonstrating that the chosen extraction technique significantly impacts the amount obtained, their biological effectiveness, and their capacity to offer anti-aging benefits.

Nov 11, 2025
Gemini
 

Deciphering The Emerging Interrelationship Between Cellular Senescence And Extracellular Vesicles: Implications For Therapy And Diagnosis

Aging Pathway
Therapeutic

Cellular senescence, a process linked to aging and disease, interacts with tiny sacs released by cells called extracellular vesicles, which can either promote or suppress this senescence and may offer new avenues for diagnosis and treatment.

Nov 11, 2025
Gemini
 

Differential Cognitive Enhancer Effects Of Acetylcholinesterase Inhibitors And Memantine On Age-Related Deficits In Vigilance And Sustained Attention: A Preclinical Validation Study

Therapeutic

This preclinical study demonstrated that different Alzheimer’s disease medications have distinct effects on age-related attention and vigilance deficits in rats, with some improving reaction time and others improving accuracy.

Nov 11, 2025
Gemini
 

Ejiao Alleviates Sarcopenia By AKT/Mtor/Foxo3A And AMPK Pathways In An Aging Rat Model Induced By D-Galactose Combined With Restricted Movement

Therapeutic
Aging Pathway

Ejiao significantly improves muscle function and provides a promising avenue for sarcopenia treatment by reducing oxidative stress, enhancing ATP levels, and modulating key pathways involved in protein synthesis and muscle function.

Nov 11, 2025
Gemini
 

ERC Accumulation Depletes Sir2 From Rdna And Induces Cellular Senescence By Rdna Destabilization

Aging Pathway

The accumulation of extrachromosomal ribosomal DNA circles in aging cells leads to the depletion of the Sir2 protein from the main ribosomal DNA, causing ribosomal DNA destabilization and promoting cellular senescence.

Nov 11, 2025
Gemini
 

Extracurricular Physical Activity And Telomere Length In Childhood: Findings From The INMA Study

Lever

Children who engaged in higher levels of extracurricular physical activity at age four showed an increase in their telomere length ranking by age eight, indicating a potential for reduced cellular damage and support for healthy aging.

Nov 11, 2025
Gemini
 

Foxo3A Upregulates DNA Repair Activities By Transcriptional Activation Of Target Genes And Provides The Resistance To Gamma Radiation And The Extension Of Lifespan In Mouse

Aging Pathway

Overexpression of the FOXO3a gene enhances DNA repair mechanisms, leading to increased resistance to radiation and an extension of lifespan in mice.

Nov 11, 2025
Gemini
 

From Structure To Immunity: How Skin Shapes Age-Related Vulnerability To Chikungunya Virus Infections

Aging Pathway

This review explores how age-related changes in the skin’s structure, immune system, and microbial community influence vulnerability to Chikungunya virus infections, especially in infants and the elderly.

Nov 11, 2025
Gemini
 

Geriatric Syndromes In Intestinal Failure: An Accelerated Aging Phenomenon In Middle Adulthood Patients?

Clock

Middle-aged patients with chronic intestinal failure exhibit a high prevalence of geriatric syndromes and premature metabolic aging, indicating that the condition may represent an accelerated aging phenomenon.

Nov 11, 2025
Gemini
 

Glycation-Lowering Compounds Inhibit Ghrelin Signaling To Reduce Food Intake, Lower Insulin Resistance, And Extend Lifespan

Therapeutic
Aging Pathway

A combination of specific compounds has been shown to reduce food intake, improve insulin sensitivity, and extend lifespan by inhibiting hunger signals and lowering harmful sugar-derived byproducts.

Nov 11, 2025
Gemini
 

Gut Metagenome And Plasma Metabolome Profiles In Older Adults Suggest Pyruvate Metabolism As A Link Between Sleep Quality And Frailty

Analytical
Aging Pathway

Research indicates that a metabolic pathway involving pyruvate, influenced by the gut microbiome, may link poor sleep quality to increased physical vulnerability in older adults.

Nov 11, 2025
Gemini
 

Identifying A Proteomics Signature Of Cognitive Impairment And Dementia In Blood And Cerebrospinal Fluid Through A Mediation Analysis Framework

Analytical

A study identified a protein called glial fibrillary acidic protein (GFAP) in both blood and cerebrospinal fluid as a strong indicator that links aging to a higher risk of cognitive decline.

Nov 11, 2025
Gemini
 

Impact Of Meditation On Brain Age Derived From Multimodal Neuroimaging In Experts And Older Adults From A Randomized Trial

Clock
Lever
Analytical

Long-term meditation practice is associated with an appearance of a younger brain compared to one’s actual chronological age.

Nov 11, 2025
Gemini
 

Interaction Between Smoking And Olfactory Function On Frailty: A Population-Based Cross-Sectional Study

Analytical
Lever

A study found that smoking and a reduced sense of smell are independently linked to an increased risk of frailty, and when combined, these factors synergistically elevate the risk of frailty even further.

Nov 11, 2025
Gemini
 

Ketone Catabolism Is Essential For Maintaining Normal Heart Function During Aging

Aging Pathway
Therapeutic
Lever

The body’s ability to break down ketones, a type of fat, is crucial for maintaining healthy heart function as individuals age.

Nov 11, 2025
Gemini
 

Lactobacillus Salivarius-Derived Indole-3-Acetic Acid Promotes AHR-Parp1 Axis-Mediated DNA Repair To Mitigate Intestinal Aging

Aging Pathway
Therapeutic

Researchers found that a molecule produced by the beneficial gut bacterium Lactobacillus salivarius can activate a specific pathway to repair DNA, which helps to slow down the aging of the intestine.

Nov 11, 2025
Gemini
 

Linker Histone Regulates The Myeloid Versus Lymphoid Bifurcation Of Multipotent Hematopoietic Stem And Progenitors

Aging Pathway
Therapeutic

Linker histones play a crucial role in directing multipotent hematopoietic stem and progenitor cells towards either myeloid or lymphoid cell types by influencing how DNA is packaged and accessed.

Nov 11, 2025
Gemini
 

Piezo1 Activation Suppresses Bone Marrow Adipogenesis To Prevent Osteoporosis By Inhibiting A Mechanoinflammatory Autocrine Loop

Aging Pathway
Therapeutic

Activation of the Piezo1 protein in bone marrow stem cells reduces fat accumulation in the bone marrow and promotes bone formation, thereby preventing osteoporosis by disrupting a self-reinforcing inflammatory process.

Nov 11, 2025
Gemini
 

Prostaglandin D2 Axis Impairs Immunity Against Melanoma Via Dendritic Cells And Γδ T Cells In Middle-Aged Mice

Aging Pathway
Therapeutic

A specific signaling pathway involving Prostaglandin D2 hinders the immune system’s ability to fight melanoma by affecting dendritic cells and a type of T cell in middle-aged mice.

Nov 11, 2025
Gemini
 

Rewarding Touch Limits Lifespan Through Neural To Intestinal Signaling

Aging Pathway

Perceiving rewarding, food-like touch can shorten the lifespan of organisms on a calorie-restricted diet by activating a signaling pathway from the nervous system to the intestine.

Nov 11, 2025
Gemini
 

Senescent Cells Promote Viral Infection-Associated Inflammation And Tissue Damage Through A Robust NF-Κb Pathway

Aging Pathway
Therapeutic

Senescent cells exacerbate inflammation and tissue damage during viral infections, especially in older individuals, through the robust activation of a cellular pathway known as NF-κB.

Nov 11, 2025
Gemini
 

Synergistic Relationship Between Muscle Thickness And Cellular Health After Resistance Training In Older Women

Lever

A 12-week resistance training program in older women leads to increased muscle thickness, which is linked to improvements in indicators of cellular health.

Nov 11, 2025
Gemini
 

Targeting Α7Nachr Mitigates Vascular Aging And Endothelial Cell Senescence Through Inhibiting Oxidative Stress And Inflammation Via Α7Nachr/Nrf2/HO-1 Signaling Pathway

Aging Pathway
Therapeutic

Targeting the α7 nicotinic acetylcholine receptor (α7nAChR) can reduce the aging of blood vessels and their lining cells by decreasing harmful oxidative stress and inflammation through a specific signaling pathway involving α7nAChR, Nrf2, and HO-1.

Nov 11, 2025
Gemini
 

Telomerase Depletion Accelerates Ageing Of The Zebrafish Brain

Aging Pathway

Depleting telomerase in zebrafish accelerates various hallmarks of brain aging, including increased inflammation, impaired blood-brain barrier function, and heightened anxiety-like behavior.

Nov 11, 2025
Gemini
 

Tgif1-Deficiency Impairs Osteoclast Differentiation Through Pp2A-Mediated Erk1/2 Dephosphorylation And Attenuates Bone Loss In Mice

Aging Pathway

Deficiency of the Tgif1 protein in bone-resorbing cells leads to impaired cell development and function, which in turn reduces age-related bone loss in mice by altering a specific molecular signaling pathway.

Nov 11, 2025
Gemini
 

The Leaves Fall, Yet The Tree Endures

Aging Theory
Aging Pathway

The paper examines how plants age, highlighting that while individual parts like leaves may senesce, the plant as a whole can achieve remarkable longevity through its continuous renewal and dynamic genetic regulatory mechanisms.

Nov 11, 2025
Gemini
 

A Full Life Cycle Biological Clock Based On Routine Clinical Data And Its Impact In Health And Diseases

Clock
Analytical

Researchers have developed an artificial intelligence model that can accurately predict a person’s biological age and future disease risks from birth through old age using standard clinical data.

Nov 10, 2025
Gemini
 

Accelerated Aging Predicts Earlier Onset Of Ischemic Stroke: A Proteomic And Transcriptomic Investigation

Clock
Analytical

A study revealed that individuals with accelerated biological aging experience ischemic strokes significantly earlier, by almost nine years, compared to those whose biological and actual ages align.

Nov 10, 2025
Gemini
 

Associations Between Reproductive Factors And Frailty In Middle-Aged And Older Women: Evidence From The China Health And Retirement Longitudinal Study

Analytical

Reproductive factors such as the number of biological children, age at menarche, history of abortion, and age at menopause are significantly linked to the risk of frailty in middle-aged and older women.

Nov 10, 2025
Gemini
 

Benchmarking Large Language Models For Personalized, Biomarker-Based Health Intervention Recommendations

Analytical

Large language models show limited suitability for providing unsupervised personalized longevity intervention recommendations based on biomarker profiles, despite proprietary models outperforming open-source ones in comprehensiveness.

Nov 10, 2025
Gemini
 

Birth Size Modifies Longitudinal Associations Between Midlife Educational Level And Physical Function At Late-Life For Men And Women

Lever

A study found that for individuals born smaller, having a lower educational level in midlife is linked to poorer physical ability in old age, an association not observed in those born larger.

Nov 10, 2025
Gemini
 

Cellular And Molecular Mechanisms Underlying Cardiovascular Aging

Aging Pathway
Therapeutic

Aging is a major risk factor for cardiovascular diseases, with alterations at the cellular and molecular levels contributing to conditions like heart failure and atherosclerosis.

Nov 10, 2025
Gemini
 

Cellular Senescence Mediates Doxorubicin Chemotherapy-Induced Vascular Endothelial Dysfunction: Translational Evidence Of Prevention With Senolytic Treatment

Aging Pathway
Therapeutic

This research indicates that cellular senescence, a process where cells stop dividing, contributes to blood vessel dysfunction caused by doxorubicin chemotherapy, and that treatments targeting these senescent cells can prevent this damage.

Nov 10, 2025
Gemini
 

Cocoa Flavanols Alleviate Early Diastolic Dysfunction By Decreasing Left Atrial Volume In A Randomized Double Blinded Trial In Healthy Older Individuals

Lever

Cocoa flavanol consumption was found to improve early signs of heart relaxation problems and reduce the size of heart chambers in healthy older adults.

Nov 10, 2025
Gemini
 

Coffee And Tea Intake, Circulating Inflammatory Biomarkers, And Long-Term Risk Of Dementia: Findings From Two Longitudinal Studies

Lever

Higher coffee consumption, specifically two or more cups per day, is associated with a reduced long-term risk of dementia, a relationship partially explained by the beverage’s impact on inflammatory markers in the body, while moderate tea intake may also be linked to a lower dementia risk.

Nov 10, 2025
Gemini
 

Early-Life Endurance Sports Lowers Frailty And Falls In Former Male Athletes

Lever

A study on older men found that former professional endurance athletes exhibited lower rates of frailty and falls in their later years compared to men who were not athletes.

Nov 10, 2025
Gemini
 

Extraction, Characterization, And Anti-Aging Evaluation Of Flavonoids From Citrus Reticulata ‘Zhangshuensis’

Therapeutic

Flavonoids extracted from a specific citrus variety were found to possess potent antioxidant and anti-aging properties, significantly extending the lifespan and stress resistance of nematodes.

Nov 10, 2025
Gemini
 

Gpx4 Ortholog Regulates The O-Glcnac-DDR Pathway To Preserve Intestinal Stem Cell Homeostasis During Aging And Oxidative Stress

Aging Pathway

A protective enzyme, similar to mammalian GPX4, helps maintain the health and function of intestinal stem cells by linking nutrient sensing and DNA repair mechanisms, especially during aging and stress.

Nov 10, 2025
Gemini
 

Hyper-Maturity And Accelerated Aging In The Hippocampus Of Mouse Models Of Neuropsychiatric Disorders With Anxiety-Like Behavior

Analytical

A new study identified “hyper-maturity” and accelerated aging of brain cells in the hippocampus, a brain region crucial for memory and emotion, as a shared abnormality in mouse models of neuropsychiatric disorders exhibiting anxiety-like behavior.

Nov 10, 2025
Gemini
 

Impact Of Aging On Gut-Lung-Adipose Tissue Interactions And Lipid Metabolism During Influenza Infection In Mice

Aging Pathway
Analytical

Aging significantly exacerbates influenza infection in mice, leading to profound alterations in white adipose tissue, gut microbiota composition, and lipid metabolism that contribute to worse disease outcomes.

Nov 10, 2025
Gemini
 

Jianpi Qiangji Granule Ameliorates Aging-Associated Sarcopenia Via AMPK/PGC-1Α Axis In Samp8 Mice

Therapeutic
Aging Pathway

A traditional Chinese medicine formula called Jianpi Qiangji Granule (JQG) has been shown to improve age-related muscle loss and enhance muscle function in aging mice by activating a key molecular pathway.

Nov 10, 2025
Gemini
 

Jianpi Qiangji Granule Ameliorates Aging-Associated Sarcopenia Via AMPK/PGC-1Α Axis In Samp8 Mice

Therapeutic
Aging Pathway

A traditional Chinese medicine, Jianpi Qiangji Granule, has been shown to improve age-related muscle loss and weakness in mice by enhancing muscle mass and function and reducing muscle cell aging.

Nov 10, 2025
Gemini
 

Leukocyte Telomere Length Mediates The Association Between SIRI And CKD: Insights From NHANES 1999-2002

Analytical

A study found that a higher systemic inflammation response index, a measure of the body’s inflammatory state, is linked to an increased risk of chronic kidney disease, and that shorter leukocyte telomere length, a marker of cellular aging, partially accounts for this connection.

Nov 10, 2025
Gemini
 

Long-Term BMI Trajectories And Epigenetic Age Acceleration: The Role Of Genetic Risk For Obesity

Analytical

Long-term obesity is associated with accelerated biological aging, particularly in individuals with a lower or moderate genetic predisposition to obesity, while being consistently overweight does not show this effect.

Nov 10, 2025
Gemini
 

Medicago Sativa L. Saponin-Driven Lactobacillus Intestinalis Restores Intestinal Stemness In Naturally Aged Mice Via The Bile Acid-FXR-Wnt Signaling Axis

Therapeutic
Aging Pathway

A compound derived from alfalfa, Medicago sativa L. saponin, was found to drive the growth of Lactobacillus intestinalis in aged mice, which then produced a bile acid that helped restore the function of intestinal stem cells by activating a specific signaling pathway.

Nov 10, 2025
Gemini
 

Multi-Cohort, Multi-Sequence Harmonisation For Cerebrovascular Brain Age

Clock
Analytical

This research found that applying specific harmonization methods to brain imaging data significantly improves the consistency of blood flow measurements and the accuracy of predicting brain age across different study groups.

Nov 10, 2025
Gemini
 

Multi-Cohort, Multi-Sequence Harmonisation For Cerebrovascular Brain Age

Clock
Analytical

New research demonstrates that adjusting for variations between MRI scanners significantly improves the accuracy of brain age predictions, especially when incorporating measures of brain blood flow to understand cerebrovascular health.

Nov 10, 2025
Gemini
 

Quantitative MRI Of The Hippocampus Reveals Microstructural Trajectories Of Aging And Alzheimer’S Disease Pathology

Analytical

Quantitative MRI can detect microstructural changes in the hippocampus, such as demyelination and iron deposition, that are associated with both healthy aging and early Alzheimer’s disease pathology.

Nov 10, 2025
Gemini
 

Ribosome Dysregulation And Intervention In Age-Related Infertility

Aging Pathway
Therapeutic

A recent study found that age-related infertility in women is associated with increased activity of genes responsible for making ribosomes in egg cells and surrounding support cells, and that a drug called rapamycin can improve embryo quality and pregnancy success in women experiencing infertility.

Nov 10, 2025
Gemini
 

Sex Differences In The Association Between Heavy Metal Exposure And Frailty In The U.S. Adults: A Cross-Sectional Analysis

Analytical

Exposure to heavy metals such as lead and cadmium is linked to an increased risk of frailty in U.S. adults, with women experiencing a more significant impact.

Nov 10, 2025
Gemini
 

TET Exhibits Enzymatic-Independent And-Dependent Functions During Drosophila Flight Muscle Development And Aging

Aging Pathway

TET, a protein known for modifying DNA, plays crucial roles in fruit fly muscle development and aging through both its DNA-modifying enzymatic activity and other independent functions.

Nov 10, 2025
Gemini
 

The Association Between A Pro-Inflammatory Diet And Brain Age In Middle-Aged And Older Adults

Lever
Analytical

A pro-inflammatory diet is associated with an accelerated brain age, particularly in older adults, suggesting that dietary choices can influence the biological aging of the brain.

Nov 10, 2025
Gemini
 

The Chinese Herbal Formular Kang Shuai Lao Pian Enhances Health Status For Skin, Adipose-Derived Stem Cells, Intestinal Microbes And Metabolites In Naturally Senescent Mice

Therapeutic
Aging Pathway

A Chinese herbal formula called Kang Shuai Lao Pian has been found to enhance the health of skin, fat-derived stem cells, gut microbes, and metabolic processes in naturally aging mice.

Nov 10, 2025
Gemini
 

The Effect Of Long-Term Adherence To Physical Activity Recommendations In Midlife On Plasma Proteins Associated With Frailty In The Atherosclerosis Risk In Communities (ARIC) Study

Lever
Analytical

Maintaining recommended levels of physical activity throughout midlife can positively influence blood proteins linked to frailty, especially those involved in the nervous system and inflammation.

Nov 10, 2025
Gemini
 

The Seminal Fluid Protein SFP-1 Regulates Mated Hermaphrodite Aging And Fat Metabolism In C. Elegans

Aging Pathway

A protein found in the seminal fluid of male C. elegans worms, called SFP-1, is transferred to hermaphrodites during mating and causes them to age faster and deplete their fat reserves.

Nov 10, 2025
Gemini
 

Analysis Of Immune Cell Remodeling And Functional Alterations Induced By Aging And Obesity In Mice

Analytical

Aging and obesity collectively alter the immune system, leading to persistent inflammation and reduced effectiveness of key immune cells.

Nov 9, 2025
Gemini
 

Deciphering The Nexus Of Aging And Pan-Cancer: Single-Cell Sequencing Reveals Microenvironmental Remodeling And Cellular Drivers

Aging Pathway
Analytical
Therapeutic

Single-cell sequencing has revealed that aging remodels the tumor microenvironment by accumulating senescent cells and diminishing anti-tumor immunity, thereby fueling cancer development and progression.

Nov 9, 2025
Gemini
 

Efficacy Of Extracellular Vesicles Derived From Mesenchymal Stromal Cells In Regulating Senescence: In Vitro And In Vivo Insights

Therapeutic

Extracellular vesicles derived from mesenchymal stromal cells have been shown to effectively reduce markers of aging, repair age-related damage, diminish oxidative stress, and normalize gene activity in both laboratory cell cultures and animal models.

Nov 9, 2025
Gemini
 

Galangin Alleviates Vascular Aging And Endothelial Cell Senescence By Targeting Smad3 To Initiate Mitophagy

Therapeutic
Aging Pathway

A natural compound called galangin has been found to slow down the aging of blood vessels and the cells lining them by boosting a cellular cleanup process that removes damaged cell components.

Nov 9, 2025
Gemini
 

Irradiation-Induced Brain Senescence Accelerates Cardiac Aging Via Systemic Mechanisms: Insights From Transcriptomic Profiling

Aging Pathway
Analytical

Brain cell aging, induced by irradiation, can accelerate the aging process in the heart through signals sent throughout the body.

Nov 9, 2025
Gemini
 

Network Toxicology And Molecular Simulation Identify Key Genes And Pathways In PFAS-Induced Premature Ovarian Insufficiency

Aging Pathway
Analytical

This research identified specific genes and biological pathways through which per- and polyfluoroalkyl substances (PFAS) contribute to premature ovarian insufficiency by impacting egg development and accelerating ovarian cell aging.

Nov 9, 2025
Gemini
 

Rosmarinic Acid Alleviates Doxorubicin-Induced Cellular Senescence And Cardiotoxicity By Targeting The 14-3-3/Foxo1 Signaling Axis

Therapeutic
Aging Pathway

Rosmarinic acid, a natural compound, has been found to reduce heart damage and cell aging caused by the chemotherapy drug doxorubicin by influencing a specific cellular pathway.

Nov 9, 2025
Gemini
 

Visualization Of OPN-Targeted Self-Assembled Micelles Encapsulated With An Sirt6 Activator And Doped Indocyanine Green For Attenuating Vascular Aging

Therapeutic
Aging Pathway

Researchers developed a visualized, targeted nanodelivery system using micelles to deliver a SIRT6 activator and an imaging agent, effectively attenuating vascular aging in a mouse model.

Nov 9, 2025
Gemini
 

A Glial Circadian Gene Expression Atlas Reveals Cell-Type And Disease-Specific Reprogramming In Response To Amyloid Pathology Or Aging

Aging Pathway
Analytical

The daily rhythms of gene activity in brain support cells are significantly altered by both the natural aging process and the presence of amyloid plaques, a hallmark of Alzheimer’s disease, with these changes being unique to different types of brain support cells.

Nov 6, 2025
Gemini
 

A Nuclear Hormone Receptor Nhr-76 Induces Age-Dependent Chemotaxis Decline In C. Elegans

Aging Pathway
Aging Theory

A nuclear hormone receptor, nhr-76, has been identified as a key regulator in the age-dependent decline of food-searching behavior in C. elegans worms.

Nov 6, 2025
Gemini
 

Age-Associated T Cell Immunity Decreases Circulating Endothelial Progenitor Cells

Aging Pathway
Therapeutic

Aging leads to an increase in certain immune T cells, which in turn reduces the number of circulating endothelial progenitor cells essential for blood vessel maintenance and repair.

Nov 6, 2025
Gemini
 

Association Between Housework Frequency And Cognitive Impairment Among Chinese Older Adults: A Prospective Cohort Study Based On CLHLS

Lever

Older Chinese adults who performed less frequent housework showed a higher risk of developing cognitive impairment.

Nov 6, 2025
Gemini
 

Cognitive Predictors Of Functional Status Transitions Among Older Adults With Seven-Year Follow-Up: A Latent Transition Analysis

Analytical

A seven-year study revealed that a strong sense of orientation is the most consistent cognitive factor protecting older adults from losing their ability to perform daily tasks.

Nov 6, 2025
Gemini
 

Design And Synthesis Of Senescence-Targeted Prodrugs With Senomorphic And Senolytic Properties To Mitigate Chemotherapy-Induced Kidney Injury

Therapeutic

Researchers have designed a new type of drug that can selectively eliminate harmful senescent cells and suppress the damaging secretions of other senescent cells, showing promise in mitigating kidney injury caused by chemotherapy.

Nov 6, 2025
Gemini
 

Electroacupuncture Plus Exercise For Sarcopenia In Older Adults: Protocol For A Randomized, Controlled, Assessor-Blinded Trial

Therapeutic
Lever

This study protocol outlines a randomized controlled trial designed to evaluate whether adding electroacupuncture to a standard exercise program can better improve walking ability and other physical functions in older adults with sarcopenia compared to exercise alone.

Nov 6, 2025
Gemini
 

Enhancing Cognition In Older Adults With Interactive Wall Exergames

Lever

Interactive wall exergames effectively enhance cognitive performance in older adults, with the combination of movement and mental tasks being the key beneficial element.

Nov 6, 2025
Gemini
 

Epigenetic Aging Signatures In People With Hemophilia

Clock

The study found weak evidence that individuals with severe hemophilia experience accelerated biological aging compared to those with mild hemophilia or healthy individuals, though hemophilic arthropathy was linked to an increased rate of biological aging.

Nov 6, 2025
Gemini
 

Evaluation Of Polygenic Risk Scores For A Possible Genetic Basis Of The Inverse Association Between Cancer And Cognitive Decline

Analytical

A study exploring genetic predispositions found a subtle connection between a higher genetic risk for certain cancers and better scores in a type of cognitive ability, hinting at shared biological pathways.

Nov 6, 2025
Gemini
 

Genetic Association Analyses Of Cognitive Performance Across Multi-Ancestry Older Adults: Application Of Tobit Models

Analytical

A new study reveals that using Tobit models, a specific type of statistical analysis, is more effective at identifying genetic factors influencing cognitive abilities in a diverse group of older adults, especially when traditional tests hit a maximum score.

Nov 6, 2025
Gemini
 

Geriatric Syndromes In Women Living With HIV

Lever

Women living with HIV face an increased risk of developing age-related health conditions, known as geriatric syndromes, at an earlier stage than other populations.

Nov 6, 2025
Gemini
 

Harmonized Cognitive Assessment Protocol (HCAP): What Makes An HCAP An HCAP? An Adaptive Architecture For Measuring Cognitive Aging Around The World

Analytical

A new framework has been developed to enable consistent and culturally relevant measurement of cognitive health in older adults across different countries.

Nov 6, 2025
Gemini
 

Induced Pluripotent Stem Cell-Derived Extracellular Vesicles Prevent Neural Stem Cell Senescence To Promote Cognitive Recovery After Traumatic Brain Injury

Therapeutic
Aging Pathway

A recent study demonstrates that tiny sacs released by induced pluripotent stem cells can prevent the aging of brain stem cells and enhance cognitive recovery, including memory and spatial orientation, following a traumatic brain injury.

Nov 6, 2025
Gemini
 

Inhibition Of The Isg15 Prevents Inflammation-Dependent Ovarian Aging

Aging Pathway
Therapeutic

Inhibiting the protein ISG15 can help prevent inflammation-related ovarian aging and improve female fertility.

Nov 6, 2025
Gemini
 

Longer Duration Of Intact Hypothalamic-Pituitary-Gonadal (HPG) Axis Buffers The Adverse Impact Of Late-Life Frailty In Male Dogs

Aging Pathway

A longer duration of an intact hypothalamic-pituitary-gonadal axis reduces the adverse effects of late-life frailty and associated mortality risk in male dogs.

Nov 6, 2025
Gemini
 

Multi-Omics Analysis Of Testis After Long-Term Exposure To Polystyrene Nanoplastics Reveals Premature Testicular Aging And Age-Dependent Damage In Mice

Aging Pathway
Analytical

Long-term exposure to polystyrene nanoplastics leads to premature testicular aging in young mice and more severe testicular damage in older mice.

Nov 6, 2025
Gemini
 

Porcine Placenta Peptides As A Complementary Functional Food For Skin Rejuvenation: A 12-Week Randomized, Double-Blind, Placebo-Controlled Trial

Therapeutic

A 12-week study found that oral supplementation with porcine placenta peptides significantly reduced wrinkles, improved skin hydration and elasticity, and decreased pigmentation in individuals with signs of skin aging.

Nov 6, 2025
Gemini
 

Prepupal Diapause Reduces Adult Lifespan In The Solitary Alfalfa Leafcutter Bee

Aging Pathway

Prepupal diapause in solitary alfalfa leafcutter bees leads to a significantly shorter adult lifespan and is associated with increased oxidative stress and altered hormone levels.

Nov 6, 2025
Gemini
 

Proteomic Polygenic Risk Scores Of Age-Related Plasma Protein Levels Reveal A Role For Metalloproteinase Inhibitor 2 (Timp2) In Cognitive Performance

Analytical
Aging Pathway

Genetically predicted higher levels of the plasma protein Metalloproteinase inhibitor 2 (TIMP2) are associated with better global cognition and memory performance in humans, consistent with its brain-rejuvenating role observed in mice.

Nov 6, 2025
Gemini
 

Requirements Of Health Professionals And Affected Persons For An App-Based Dual-Task Training For Hearing Impaired Older Adults - A Delphi Survey

Lever

A study investigating app-based training for older adults with hearing impairments found differences in preferred training methods and app features between health professionals and the affected individuals themselves.

Nov 6, 2025
Gemini
 

Rewarding Touch Limits Lifespan Through Neural To Intestinal Signaling

Aging Pathway
Lever

Rewarding tactile sensations, such as those mimicking food, can reduce the lifespan-extending benefits of a restricted diet by activating a signaling pathway from the nervous system to the gut.

Nov 6, 2025
Gemini
 

Sex-Specific Factors And Apoeε4 Genotype Alter Functional Connectivity At Middle Age

Aging Pathway

Previous pregnancies and the APOEε4 genetic risk factor for Alzheimer’s disease significantly alter how different brain regions communicate, influencing cognitive function in middle-aged individuals, particularly females.

Nov 6, 2025
Gemini
 

The Ability Of Activity And Cognition In Old Mice To Predict Age Of Death

Clock
Analytical

A study in old mice revealed that while individual measures like voluntary running activity showed some connection to lifespan, a combination of various physical activity and cognitive factors significantly predicted their age of death.

Nov 6, 2025
Gemini
 

The Longitudinal Association Between Dyslipidemia And Cognitive Trajectory

Analytical

An imbalance of fats in the blood is linked to a faster decline in thinking abilities, including memory and language skills, in older adults.

Nov 6, 2025
Gemini
 

The Predictive Power Of Brain-Predicted Age And Leg Strength On Mobility Decline In Aging: Findings From The Baltimore Longitudinal Study Of Aging

Clock
Analytical

The study found that both accelerated brain aging, as measured by brain-predicted age, and weaker leg strength independently predict a decline in mobility among older adults.

Nov 6, 2025
Gemini
 

Vitamin B12 Deficiency Among Older Adults And Its Associations With Geriatric Syndromes

Therapeutic

Vitamin B12 deficiency is prevalent and often undiagnosed in older adults, and it is consistently associated with various age-related health issues known as geriatric syndromes.

Nov 6, 2025
Gemini
 

What Changes First? Mapping The Temporal Ordering Of Age-Related Functional Decline Across Domains Using 30-Year Longitudinal Data

Analytical

Longitudinal research indicates that declines in physical and cognitive abilities generally emerge before changes in social functioning, with no distinct order found for emotional well-being.

Nov 6, 2025
Gemini
 

Wide-Band Electrical-Impedance-Spectroscopy Integrated Microfluidic Organism-On-A-Chip Device For Simultaneous Monitoring Of Multi-Organ Degradation Along C. Elegans Aging

Analytical

A novel microfluidic device integrated with electrical impedance spectroscopy has been developed to simultaneously monitor the degradation of multiple organs in C. elegans as they age.

Nov 6, 2025
Gemini
 

Association Of Estimated Glucose Disposition Rate With Aging Acceleration And Mortality Risk In Individuals With Cardiovascular-Kidney-Metabolic Syndrome: Evidence From Two Large National Population-Based Studies

Analytical

A lower estimated glucose disposition rate is linked to accelerated biological aging and a higher risk of death in individuals diagnosed with cardiovascular-kidney-metabolic syndrome.

Nov 5, 2025
Gemini
 

Bacillus Subtilis TO-A Suppresses The Age-Related Decline In Locomotion In Caenorhabditis Elegans

Therapeutic

A probiotic bacterium, Bacillus subtilis TO-A, has been found to prevent the age-related decrease in movement in the model organism Caenorhabditis elegans by maintaining muscle structure and influencing genes related to oxidative stress.

Nov 5, 2025
Gemini
 

Comprehensive Analysis Of Aberrant Alternative Splicing And RNA Binding Proteins Associated With Age-Related Sensorineural Hearing Loss

Analytical
Aging Pathway

Research has identified numerous altered gene processing events and their regulating proteins linked to age-related sensorineural hearing loss in a mouse model, with ISG15 emerging as a crucial regulator of these processes.

Nov 5, 2025
Gemini
 

Diet, Nutrition, And Healthy Aging: Are Mirnas The Link? A Narrative Review

Aging Pathway

MicroRNAs may serve as a crucial molecular link, explaining how dietary intake can regulate gene expression and consequently impact the aging process and overall lifespan.

Nov 5, 2025
Gemini
 

Emerging Perspectives In Anti-Aging Treatments Using Anti-Fibrotic Strategies

Therapeutic
Aging Pathway

Excessive scar tissue buildup, known as fibrosis, is a key characteristic of aging organ degeneration and a significant factor in organ failure, suggesting anti-fibrotic treatments could offer new strategies for anti-aging.

Nov 5, 2025
Gemini
 

Evidence Of Biological Aging Through Mitochondrial DNA Damage And Dysregulation Of Mitophagy-Related Genes In Veterans With Delayed Sulfur Mustard Toxicity

Aging Pathway

Exposure to sulfur mustard causes long-lasting damage to the powerhouses of cells, called mitochondria, and disrupts their ability to clean up faulty components, leading to accelerated biological aging in affected individuals.

Nov 5, 2025
Gemini
 

Fisetin Topical Delivery Via Ascorbyl Palmitate/Hyaluronan-Enhanced Limosomes: A Novel Paradigm For Preventing UVB-Induced Skin Photoaging

Therapeutic

A new delivery system using limosomes enhanced with ascorbyl palmitate and hyaluronan effectively transports the antioxidant Fisetin into the skin, significantly reducing signs of UVB-induced photoaging and inflammation.

Nov 5, 2025
Gemini
 

Fundc1 Deficiency Aggravates Endothelial Senescence And Retinal Dysfunction

Aging Pathway
Therapeutic

A lack of the protein FUNDC1 worsens the aging of blood vessel lining cells and contributes to the decline in retinal function.

Nov 5, 2025
Gemini
 

Gaining Brain Insights By Tapping Into The Black Box: Linking Structural MRI Features To Age And Cognition Using Shapley-Based Interpretation Methods

Analytical

The study revealed that average signal strengths in brain regions beneath the cortex are consistently linked to brain aging, while specific areas like the hippocampus, cerebellum, and parts of the frontal and temporal lobes are key in predicting fluid intelligence.

Nov 5, 2025
Gemini
 

How Does Life Course Exposure To Contextual Disadvantage Accelerate Biological Aging? The Role Of Psychological Symptoms

Clock

Living in disadvantaged neighborhoods over one’s lifetime accelerates biological aging, partly due to increased psychological distress.

Nov 5, 2025
Gemini
 

Macrophage Metabolic Rewiring Rejuvenates Muscle Raman Signatures And Cellular Remodeling During Regrowth In Aged Mice

Aging Pathway
Therapeutic

Metabolically stimulating macrophages with transient low oxygen conditions improved muscle cellular remodeling and functional recovery in aged mice following disuse atrophy, restoring a youthful recovery pattern.

Nov 5, 2025
Gemini
 

Mettl3-Mediated Modification Of Sirt1 M6A Methylation Protects Osteoblasts From TBHP-Induced Senescence And Promotes Osteoblast Proliferation

Aging Pathway

Research indicates that a specific genetic modification, METTL3-mediated SIRT1 m6A methylation, helps protect bone-forming cells from chemically-induced aging and promotes their multiplication.

Nov 5, 2025
Gemini
 

Microglial Replacement Reverses Age-Associated Epigenetic Modifications Despite Accelerating Epigenetic Age

Clock
Therapeutic

Microglial replacement reverses a substantial portion of age-related chemical modifications to DNA, particularly in immune-related pathways, even though it appears to accelerate the overall epigenetic age.

Nov 5, 2025
Gemini
 

Non-Autonomy Of Age-Related Morphological Changes In The C. Elegans Germline Stem Cell Niche

Aging Pathway

Age-related changes in the morphology of the stem cell niche in C. elegans, specifically the distal tip cell, are surprisingly regulated by signals originating from the body wall muscle, rather than solely within the niche itself, through insulin-like signaling pathways.

Nov 5, 2025
Gemini
 

Protein Catabolites As Blood-Based Biomarkers Of Aging Physiology: Findings From The Dog Aging Project

Analytical

A study using data from the Dog Aging Project identified specific protein breakdown products in the blood, called post-translationally modified amino acids, as reliable indicators of aging in dogs, with kidney function mediating about half of their age-related increase.

Nov 5, 2025
Gemini
 

Recombinant Type I & III Chimeric Collagen Significantly Enhances The Vitality Of Fibroblasts And Decelerates The Skin Aging Process

Therapeutic

A newly developed dual-function recombinant collagen, combining elements of type I and type III collagens, effectively boosts skin cell activity and reduces visible signs of aging.

Nov 5, 2025
Gemini
 

Redox-Sensitive High Mobility Group Box 1 (Hmgb1) Is A Multifunctional Regulator Of Cellular Senescence, Inflammation, And Immunosuppression: Impact On The Aging Process

Aging Pathway

The protein HMGB1, which is sensitive to the cellular environment, acts as a multi-functional regulator impacting cellular aging, inflammation, and the immune system, thereby influencing the overall aging process.

Nov 5, 2025
Gemini
 

Sirt1-Mediated Mitochondrial Homeostasis In Cardiac Aging: Molecular Mechanisms And Therapeutic Implications

Aging Pathway
Therapeutic

SIRT1 plays a crucial role in maintaining healthy mitochondria within heart cells, which is essential for counteracting the effects of aging on the heart and may offer new avenues for treating age-related heart conditions.

Nov 5, 2025
Gemini
 

Stem Cell-Free Therapy For Healthy Brain Aging: Mechanisms, Challenges, And Prospects

Therapeutic
Aging Pathway

A new approach to combat brain aging involves utilizing beneficial substances released by stem cells, rather than the cells themselves, to promote brain health and regeneration with potentially fewer risks.

Nov 5, 2025
Gemini
 

Tissue And Cellular Spatiotemporal Dynamics In Colon Aging

Aging Pathway
Analytical

Researchers have created a detailed map showing how the cells and tissues of the colon change over time and across different regions as it ages.

Nov 5, 2025
Gemini
 

Two-Phase Model Of Ageing In Mice For Improved Identification Of Age-Related And Late Life Metabolic Decline

Aging Theory

A study in mice reveals a two-phase aging process where a distinct set of physiological and metabolic changes indicates the final stage of life, independent of an individual’s actual age.

Nov 5, 2025
Gemini
 

An Ad Libitum-Fed Diet That Matches The Beneficial Lifespan Effects Of Caloric Restriction But Acts Via Opposite Effects On The Energy-Splicing Axis

Lever

A new study in mice found that a specific low-protein, high-carbohydrate diet, consumed without restriction, extends lifespan and improves metabolic health similarly to caloric restriction, but through distinct cellular mechanisms.

Nov 4, 2025
Gemini
 

Angiopoietin-Like 8 Governs Osteoblast-Adipocyte Lineage Commitment During Skeletal Aging

Aging Pathway

A protein called Angiopoietin-like 8 (ANGPTL8) promotes the formation of fat cells over bone cells from stem cells in the bone marrow during aging, contributing to age-related bone loss and increased bone marrow fat.

Nov 4, 2025
Gemini
 

Antagonistic Regulation Of LINE-1/Alu Elements And Their Repressor Apobec3B In Cellular Senescence

Aging Pathway

Reduced levels of the protein APOBEC3B in aging cells lead to increased activity of mobile genetic elements, contributing to DNA damage and the aging process.

Nov 4, 2025
Gemini
 

Assortative Breeding Experiment In A Songbird Suggests Telomere Length Is Determined During Early Life Rather Than At Conception

Clock

A study on songbirds suggests that an individual’s initial telomere length is established during early development, specifically around hatching, rather than being set at the moment of conception.

Nov 4, 2025
Gemini
 

Comparing Loss Of Individual Fragile X Proteins Suggests Strong Links To Cellular Senescence And Aging

Aging Pathway

The absence of individual fragile X proteins is significantly linked to cellular aging and the process by which cells permanently stop dividing.

Nov 4, 2025
Gemini
 

Different Gametogenesis States Uniquely Impact Longevity In Caenorhabditis Elegans

Aging Pathway

Disrupting the reproductive system in different ways in the tiny worm C. elegans leads to varied impacts on their lifespan, even when all the worms accumulate extra fat.

Nov 4, 2025
Gemini
 

Environmental Chemical Factors Associated With Human Biological Age Acceleration: An Interpretable Machine Learning Study

Clock
Analytical

An interpretable machine learning study identified specific environmental chemicals like blood toluene, a urinary benzene metabolite, and urinary benzophenone-3 as key contributors to an accelerated biological aging process in humans.

Nov 4, 2025
Gemini
 

Genistein Ameliorates Glucose-Induced Β-Amyloid Toxicity, Oxidative Stress, And Aging In The C. Elegans Model Of Alzheimer’S Disease

Lever
Therapeutic

Genistein, a compound derived from soy, was observed to extend lifespan and reduce symptoms resembling Alzheimer’s disease in a C. elegans model, by addressing toxicity caused by a specific protein accumulation, cellular damage from unstable molecules, and aspects of aging linked to high glucose levels.

Nov 4, 2025
Gemini
 

Immunosenescence: Shaping The Hematological Narrative In The Era Of Aging

The aging of the immune system, known as immunosenescence, plays a crucial role in shaping the development and progression of various blood-related disorders, impacting both disease risk and the effectiveness of treatments.

Nov 4, 2025
Gemini
 

O304 Is A Mitochondrial Uncoupler Which Extends C. Elegans Lifespan And Induces Vasorelaxation Of Rat Mesenteric Arteries

Lever
Therapeutic

A compound designated O304 has been found to extend the lifespan of C. elegans worms and relax rat blood vessels by acting as a mitochondrial uncoupler.

Nov 4, 2025
Gemini
 

Obstructive Sleep Apnea And Aging Of The Cardiovascular System: A Multidimensional Analysis Of The Mechanisms Involved

Aging Pathway

Obstructive sleep apnea accelerates the aging of the cardiovascular system through multiple pathways, including cellular senescence, mitochondrial dysfunction, metabolic dysregulation, telomere attrition, impaired intercellular communication, and adipose tissue senescence.

Nov 4, 2025
Gemini
 

P-Selectin Overexpression Impairs Hematopoietic Stem Cell Homeostasis Via Inflammatory Receptor-Mediated Proliferation And Differentiation

Aging Pathway

Overexpression of P-selectin impairs the ability of hematopoietic stem cells to maintain a healthy blood and immune system by causing them to over-proliferate and differentiate prematurely, particularly during aging and inflammation, but it also shows potential to inhibit leukemia stem cells.

Nov 4, 2025
Gemini
 

Phenotypes, Mechanisms, And Therapeutic Strategies Of Natural Killer Cell Immunosenescence

Therapeutic

This paper reviews the characteristics, underlying processes, and potential treatments for the age-related decline in function of natural killer immune cells, which are crucial for fighting infections and tumors.

Nov 4, 2025
Gemini
 

Profile Of Biological Aging In First Primary Cancers: A Pan-Cancer Analysis Of Two Large-Scale Cohorts From The UK And Hong Kong

Clock
Analytical

Biological aging that progresses faster than a person’s chronological age is associated with an elevated risk of developing various cancers, with a particularly strong link to lung cancer incidence and mortality.

Nov 4, 2025
Gemini
 

Reproductive Fitness And The Links To Chronic Disease And Systemic Aging

Aging Theory

Female reproductive aging is the earliest indicator of aging in humans, and reproductive health, including normal transitions and disorders, significantly influences long-term systemic health and the risk of chronic diseases.

Nov 4, 2025
Gemini
 

Single-Cell RNA Sequencing Identifies Accumulation Of Fcgr2B + Virtual Memory-Like Cd8 T Cells With Cytotoxic And Inflammatory Potential In Aged Mouse White Adipose Tissue

Aging Pathway

Single-cell RNA sequencing revealed that aging in mice leads to an accumulation of a specific type of immune cell, called Fcgr2b+ virtual memory-like CD8 T cells, within white adipose tissue, which possess the ability to cause both cell damage and inflammation.

Nov 4, 2025
Gemini
 

Spatiotemporal Transcriptomic Characteristics Of Immune And Metabolic Dysregulation During Mouse Brain Aging

A comprehensive study mapped gene activity across different mouse brain regions throughout the aging process, revealing distinct patterns of immune system activation and metabolic changes over time.

Nov 4, 2025
Gemini
 

Telomerase And Alternative Lengthening Of Telomeres Coexist In The Regenerating Zebrafish Caudal Fins

Aging Pathway

Zebrafish maintain the protective caps on their chromosomes, called telomeres, during fin regeneration through both the telomerase enzyme and an alternative repair pathway, especially when telomerase is absent.

Nov 4, 2025
Gemini
 

The Metabolic Transition Between Fasting And Feeding Alters Aging-Associated Metabolites, Lowers Bcaas, And Stimulates Fgf21 Production In Humans

Analytical
Aging Pathway

The refeeding period after a fast significantly alters metabolic markers associated with aging, decreases branched-chain amino acids, and increases the production of the hormone FGF21 in humans.

Nov 4, 2025
Gemini
 

The Multiomics Blueprint Of The Individual With The Most Extreme Lifespan

Clock
Analytical

A multiomics study of the world’s oldest living person revealed that despite exhibiting some molecular hallmarks of aging, she lacked major age-associated diseases due to resilient genetic variants, a low-inflammation metabolic profile, a rejuvenated microbiome, and a younger epigenome.

Nov 4, 2025
Gemini
 

Zc3H4, A Novel Regulator Of Mitochondrial Complex I, Impacts Prostate Stromal Cell Senescence, Attachment, Adhesion And Anoikis Resistance

Aging Pathway

Loss of the protein ZC3H4 disrupts mitochondrial function, leading to changes in prostate stromal cells that contribute to cellular aging, altered cell binding, and resistance to cell death, mimicking aspects of prostate enlargement.

Nov 4, 2025
Gemini
 

20(S)-protopanaxadiol prolongs lifespan and enhances stress resistance in Caenorhabditis elegans via the insulin/IGF-1 signaling pathway.

Aging Pathway

A compound called 20(S)-protopanaxadiol was found to extend the lifespan and improve stress resistance in Caenorhabditis elegans worms by acting on the insulin/IGF-1 signaling pathway.

Nov 3, 2025
Gemini
 

A novel miRNA-TF-mRNA regulatory network associated with cellular senescence in osteoporosis.

Aging Pathway

A newly identified genetic pathway involving a small RNA molecule and a specific gene has been found to drive the development of osteoporosis by promoting cell aging and fat accumulation while hindering bone formation.

Nov 3, 2025
Gemini
 

A receptor for glycation end products (RAGE) is a key transmitter between garb-aging and inflammaging.

Aging Pathway

The receptor for glycation end products (RAGE) acts as a crucial link connecting the accumulation of cellular waste products with the chronic inflammation observed in aging.

Nov 3, 2025
Gemini
 

Advancing Single-Cell Transcriptomic Analysis To Reveal Age-Related Skeletal Muscle Changes: A Systematic Review

Age-related changes in skeletal muscle involve alterations in cellular composition, increased inflammation, and disrupted cellular processes such as regeneration, as revealed by advanced single-cell analysis techniques.

Nov 3, 2025
Gemini
 

Age and sex influence diurnal memory oscillations, circadian rhythmicity, and Per1 expression.

Aging Pathway

Memory performance and daily body clock patterns fluctuate depending on an individual’s age and sex, with the gene Per1 playing a role in these processes.

Nov 3, 2025
Gemini
 

Age- and sex-specific transcriptomic changes drive the prothrombotic potential of megakaryocytes.

Research indicates that the cells responsible for producing platelets, called megakaryocytes, undergo distinct changes with age that vary between sexes, influencing the risk of blood clot formation.

Nov 3, 2025
Gemini
 

Aging-rewired metabolic cues promote autophagy and senescence via DRAM1.

Aging Pathway

The study reveals that metabolic changes associated with aging, specifically the buildup of N-acetylhistamine and phosphatidylethanolamine, promote a specialized form of autophagy involving the protein DRAM1, which contributes to cellular aging and senescence.

Nov 3, 2025
Gemini
 

Association Of Biological Age Acceleration With All-Cause And Cardiovascular Mortality In HSV-Positive Adults: A Population-Based Longitudinal Cohort Study

Clock
Analytical

Individuals infected with the herpes simplex virus who show signs of accelerated biological aging face a higher risk of death from all causes and cardiovascular disease.

Nov 3, 2025
Gemini
 

Atorvastatin Ameliorates Cerebral Cortical Pathological And Cognitive Alterations In Aged Rats: Histological & Immunohistochemical Study

Therapeutic
Lever

Atorvastatin demonstrated a neuroprotective effect in aged rats by improving memory function and reducing age-related brain changes through the regulation of oxidative stress, inflammation, apoptosis, and cellular cleanup processes.

Nov 3, 2025
Gemini
 

Characterization of the Intact Proteomic Profile of Senescent-Associated Secretory Phenotype by Top-Down Mass Spectrometry.

Researchers have used an advanced proteomic technique to identify previously unknown intact protein forms and their modifications in the secretions of senescent cells, including potential new biomarkers for aging.

Nov 3, 2025
Gemini
 

Correlations between Aging, Telomeres, and Natural Compounds.

The paper investigates the intricate relationship between the aging process, the protective caps on chromosomes called telomeres, and the potential therapeutic effects of various natural compounds in promoting a longer and healthier life by influencing age-related cellular pathways.

Nov 3, 2025
Gemini
 

Embryonic stem cell-derived extracellular vesicles delay cellular senescence by inhibiting oxidative stress.

Lever

Embryonic stem cell-derived extracellular vesicles can delay the aging of cells by inhibiting oxidative stress, a process that damages cells.

Nov 3, 2025
Gemini
 

High-fat diet attenuates vestibular and auditory dysfunction in aged mice via macrophage-mediated anti-inflammatory mechanisms.

Lever
Aging Pathway

A high-fat diet was found to slow down the decline of both balance and hearing abilities in aged mice by promoting immune cells that reduce inflammation.

Nov 3, 2025
Gemini
 

Increase of brain Aβ peptides and secretase activity during normal aging in rodent and human.

Aging Pathway

Normal aging leads to an increase in amyloid beta protein fragments and the activity of a specific enzyme called beta-secretase in the brains of rodents and humans.

Nov 3, 2025
Gemini
 

Inflammaging and Senescence-Driven Extracellular Matrix Remodeling in Age-Associated Cardiovascular Disease.

Aging Pathway

Chronic low-grade inflammation and the accumulation of senescent cells are key drivers of detrimental structural changes in the heart and blood vessels, contributing significantly to age-associated cardiovascular diseases.

Nov 3, 2025
Gemini
 

LCN2 promotes HEI-OC1 cells senescence via activating NF-κB signal pathway in presbycusis.

Aging Pathway

A study found that a protein called LCN2 promotes the aging of inner ear cells by activating a specific signaling pathway, contributing to age-related hearing loss.

Nov 3, 2025
Gemini
 

Near infrared LED irradiation reverses the declining quality of mice post-ovulatory aging and reproductive aged oocytes†.

Lever

Near-infrared LED light exposure has been shown to improve the quality of aged mouse egg cells by revitalizing their cellular energy powerhouses.

Nov 3, 2025
Gemini
 

Revealing the Interplay of Intraorganellar O2•- and ATP in Brain Aging-Related Alzheimer’s Disease via Unimolecular Dual-Responsive Probes.

Researchers developed tools to observe the interplay of a damaging molecule called superoxide and the cell’s energy currency, ATP, within brain cell compartments, finding that aging cells affected by Alzheimer’s-related proteins experience an imbalance where damaging superoxide increases before ATP decreases.

Nov 3, 2025
Gemini
 

Sirolimus Use In Allogeneic Hematopoietic Cell Transplant Recipients: Assessing Its Senotherapeutic Role In A High Risk Population

Analytical
Therapeutic

The study investigated whether sirolimus, when used at standard doses to prevent complications after allogeneic hematopoietic cell transplantation, demonstrates a significant anti-aging effect by reducing cellular senescence.

Nov 3, 2025
Gemini
 

Targeting Genome Stability to Mitigate Human Aging and Disease.

Maintaining the stability of our genetic material is crucial for healthy aging and disease prevention, with strategies focusing on DNA repair and managing cellular responses to damage.

Nov 3, 2025
Gemini
 

Vitamin C conveys geroprotection on primate ovaries.

Lever
Therapeutic

A long-term study in monkeys demonstrated that regular oral vitamin C intake can slow down the aging process of their ovaries.

Nov 3, 2025
Gemini
 

Empagliflozin slows down natural kidney senescence via Six1/Wnt4/NF-κB pathway.

Therapeutic
Lever

A medication called empagliflozin has been shown to slow down the natural aging process in kidneys by targeting specific molecular pathways.

Nov 2, 2025
Gemini
 

Enhancing the Anti-Aging Potential of Green Tea Extracts Through Liquid-State Fermentation with Aspergillus niger RAF106.

Lever
Therapeutic

Liquid-state fermentation of green tea extracts with the fungus Aspergillus niger RAF106 significantly boosts their anti-aging capabilities, leading to an extended lifespan and improved health indicators in a model organism.

Nov 2, 2025
Gemini
 

Molecular Framework of the Onset and Progression of Skeletal Muscle Aging.

Aging Theory

Skeletal muscle aging commences during middle age with subtle molecular alterations, preceding the noticeable loss of muscle mass and function.

Nov 2, 2025
Gemini
 

Welcome To Aging Papers

This website will host summaries of the most recent scientific papers published about aging. It will be updated daily.
Oct 26, 2025
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