Mettl3-Mediated Modification Of Sirt1 M6A Methylation Protects Osteoblasts From TBHP-Induced Senescence And Promotes Osteoblast Proliferation
Maintaining healthy bones relies on the continuous activity of special cells called osteoblasts, which are responsible for building new bone tissue. However, these vital cells can undergo a process called senescence, where they stop dividing and lose their ability to function effectively, contributing to age-related bone conditions.
A recent study sheds light on a molecular mechanism that appears to safeguard these crucial bone cells. The research suggests that a specific chemical modification, known as m6A methylation (a tag on RNA molecules), on a protein called SIRT1, when guided by another protein named METTL3, plays a protective role. This modification helps shield osteoblasts from senescence, particularly when exposed to damaging agents like TBHP (tert-butyl hydroperoxide). Furthermore, this process also promotes the healthy growth and multiplication (proliferation) of osteoblasts, which is essential for bone repair and maintenance. Understanding these molecular interactions could pave the way for new strategies to preserve bone health and prevent age-related decline.