Efficacy Of Extracellular Vesicles Derived From Mesenchymal Stromal Cells In Regulating Senescence: In Vitro And In Vivo Insights
Scientists are exploring new ways to combat the effects of aging and age-related diseases. One promising area of research involves tiny packages released by special cells called mesenchymal stromal cells. These packages, known as extracellular vesicles (EVs), act like messengers, carrying vital components such as growth factors, beneficial fats, and regulatory molecules between cells.
Recent advancements have led to the development of a method to produce these EVs for potential clinical use, complete with quality control standards. In laboratory studies, these EVs significantly reduced several indicators of aging in human skin cells, while also boosting the production of beneficial proteins like collagen.
Further studies in animal models showed that these EVs could alleviate signs of aging, improving tissue health, reducing cellular stress caused by harmful molecules (oxidative stress), and normalizing the activity of genes linked to aging. The primary ways these EVs seem to work include battling oxidative stress and fine-tuning the body’s metabolic processes.
These findings suggest that these naturally derived vesicles hold significant potential as a novel approach for addressing aging and related health conditions.
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