Medicago Sativa L. Saponin-Driven Lactobacillus Intestinalis Restores Intestinal Stemness In Naturally Aged Mice Via The Bile Acid-FXR-Wnt Signaling Axis
As we age, our bodies undergo many changes, and our gut health is no exception. A decline in the function of intestinal stem cells, which are crucial for repairing and renewing the gut lining, contributes significantly to age-related intestinal issues. But what if a natural compound could help reverse this decline?
Recent research has shed light on the potential of plant-derived compounds called saponins, specifically those from alfalfa (Medicago sativa L.). The study uncovered that consuming these alfalfa saponins led to an increase in a beneficial gut bacterium called Lactobacillus intestinalis in naturally aged mice. This particular bacterium has a fascinating role: it produces a bile acid known as ursodeoxycholic acid.
Ursodeoxycholic acid then acts as a signal in the gut, effectively working against another receptor called FXR. This action, in turn, activates the Wnt signaling pathway, which is a fundamental pathway known for its critical role in maintaining the health and regeneration of intestinal stem cells. By boosting this pathway, the stem cells regain their youthful vigor, helping to restore overall intestinal health and function.
This discovery points towards an exciting possibility: developing new, natural strategies to combat the effects of aging on the gut by leveraging the power of plant compounds and our own gut microbiota.
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