Preventive Effect Of Fisetin On Follicular Granulosa Cells Senescence Via Attenuating Oxidative Stress And Upregulating The Wnt/Β-Catenin Signaling Pathway
As animals age, a critical process for reproduction, the health of cells surrounding developing eggs, can decline. This decline is often due to something called “oxidative stress,” which is essentially damage caused by unstable molecules in the body. When these crucial cells, known as granulosa cells, suffer from this stress, they can age prematurely and stop functioning properly, leading to a reduction in the number of healthy eggs produced.
Recent research has shed light on a natural compound called fisetin, which shows promise in combating this issue. Scientists discovered that fisetin can act as a protective agent, helping to prevent the early aging of these important egg-supporting cells. It achieves this by significantly reducing the oxidative stress they experience. Additionally, fisetin helps to improve the cells’ ability to grow and divide normally, a process often disrupted in aging cells. It does this by boosting specific internal communication networks within the cells, which are vital for protection and proper function. These findings suggest a potential way to maintain the health of reproductive cells, which could have implications for prolonging reproductive vitality.
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