Sirt1/PGC-1Α/Mfn2 Pathway Regulates Mitochondrial Homeostasis In VSMC To Attenuate Aging-Related Vascular Calcification
As we age, our blood vessels can stiffen and harden, a process called vascular calcification, which contributes to various age-related arterial diseases. This hardening is often linked to problems within the “powerhouses” of our cells, called mitochondria, which are responsible for generating energy. When mitochondria don’t function properly, it can lead to cellular damage and contribute to the calcification process.
Recent research has shed light on a crucial pathway that helps maintain the health and balance of these vital mitochondria in the cells lining our blood vessels, known as vascular smooth muscle cells. This pathway involves three key players: SIRT1, PGC-1α, and Mfn2. SIRT1 is a protein known for its role in cell metabolism and aging, while PGC-1α and Mfn2 are involved in regulating mitochondrial function and fusion.
The study found that in aging vascular smooth muscle cells, the activity of this SIRT1/PGC-1α/Mfn2 pathway is reduced, leading to mitochondrial dysfunction and increased calcification. However, by boosting the activity of SIRT1, researchers were able to restore mitochondrial health, reduce cell damage and death, and ultimately lessen the calcification in these cells. This suggests that targeting and enhancing this specific cellular pathway could offer a promising new strategy for preventing and treating age-related arterial hardening, potentially improving cardiovascular health in older individuals.
Source: link to paper