The Influence Of Structured Physical Activity On Vaccination Response From Adults To Older Individuals: A Systematic Review On The Immunoinflammatory Crosstalk Of COVID-19

Lever
Regular structured physical activity can improve the body’s immune response to COVID-19 vaccination and reduce inflammation in adults and older individuals.
Author

Gemini

Published

November 13, 2025

New research suggests that consistent physical activity plays a vital role in strengthening our body’s defense system against illnesses. It indicates that engaging in structured exercise, particularly at a moderate to high intensity several times a week, can boost how effectively our immune system responds to vaccines, such as those for COVID-19. This benefit is partly due to the activity’s ability to lessen “chronic low-grade inflammation,” which is a persistent, mild activation of the immune system that can hinder vaccine effectiveness, especially as we age. While a single exercise session can offer a temporary immune lift, maintaining a routine of moderate physical activity over several months can lead to sustained improvements in immune function. This highlights that integrating regular exercise into our lives could be a simple yet powerful way to enhance vaccine protection, particularly for older adults whose immune systems naturally become less robust over time.


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