Vitamin D And The Aging Skin: Insights Into Oxidative Stress, Inflammation, And Barrier Function
As we age, our skin undergoes changes driven by factors like damage from unstable molecules called free radicals, persistent low-grade inflammation, and a weakening of its protective outer layer. These processes contribute to the visible signs of aging, such as wrinkles and reduced resilience.
Recent research highlights the significant role of Vitamin D and its associated receptor (VDR) in counteracting these effects. This Vitamin D system acts like a central control hub, responding to signals from sunlight, cellular stress, and metabolism to help maintain the skin’s immune balance and structural integrity.
Specifically, Vitamin D helps the skin by boosting its natural antioxidant defenses, which fight off damaging free radicals. It also plays a key role in calming inflammation, a process often referred to as “inflammaging” when it contributes to aging. Furthermore, Vitamin D supports the skin’s barrier function, which is essential for keeping moisture in and harmful substances out. By influencing various cellular pathways, Vitamin D helps to slow down the structural and functional decline of aging skin, suggesting its potential as a valuable tool in strategies to maintain healthy, youthful skin.
Source: link to paper