A Proposed Path To Explaining The Unexplained Anemia Of Aging
Many older adults experience anemia, a condition where their blood lacks healthy red blood cells, leading to fatigue and weakness. What’s particularly puzzling is that for a significant number of these individuals, the cause of their anemia remains a mystery, often termed “unexplained anemia of aging.” This isn’t just a minor issue; it can have serious health consequences, including increased risk of hospitalization and even death.
Recent discussions among experts have shed light on several potential culprits behind this unexplained anemia. One key area is “inflammaging,” a term describing the low-grade, chronic inflammation that often accompanies aging. This persistent inflammation can interfere with the body’s ability to produce red blood cells effectively.
Another factor under consideration is the gut microbiome – the community of bacteria living in our intestines. These microbes play a crucial role in how our bodies absorb and regulate iron, a vital component of red blood cells. Changes in the gut bacteria with age might disrupt this process.
Experts also highlight the importance of screening for “clonal hematopoiesis,” a condition where certain blood stem cells acquire mutations and begin to outcompete normal blood cells. While not always cancerous, it can be a precursor to blood cancers and is more common in older individuals.
Furthermore, the natural aging process itself affects the function of hematopoietic stem cells, which are responsible for producing all blood cells, including red blood cells. Hormonal changes, particularly declines in sex hormones, may also contribute to the development of anemia in older adults.
By exploring these interconnected factors, researchers hope to develop better diagnostic tools and more effective treatments. The ultimate goal is to move beyond simply labeling anemia as “unexplained” and instead pinpoint the underlying causes, improving the health and quality of life for older adults.
Source: link to paper