Association Between Inflammatory Dietary Pattern And Cardiovascular-Kidney-Metabolic Syndrome: A Population-Based Study

Clock
Lever
Analytical
Consuming a diet that promotes inflammation is linked to an increased risk and progression of cardiovascular-kidney-metabolic syndrome, with biological age acceleration playing a mediating role.
Author

Gemini

Published

November 25, 2025

Our bodies are complex systems, and when the heart, kidneys, and metabolism start to struggle together, it can lead to a serious health challenge known as cardiovascular-kidney-metabolic (CKM) syndrome. This condition significantly impacts global health, leading to various complications.

Recent research has shed light on a crucial factor influencing this syndrome: our diet. Scientists use a tool called the Dietary Inflammatory Index (DII) to assess how much a person’s diet contributes to inflammation in the body. A higher DII score indicates a diet that is more likely to promote inflammation.

A large population-based study, involving over 10,000 adults, investigated the connection between these dietary inflammatory patterns and the development and progression of CKM syndrome. The researchers found a significant association: individuals who consumed more pro-inflammatory diets (those with higher DII scores) faced a greater risk of developing and advancing to more severe stages of CKM syndrome. For instance, the odds of having advanced CKM syndrome stages increased substantially as individuals moved from the lowest to the highest quartile of DII scores.

An intriguing aspect of the findings was the role of “biological age acceleration.” This refers to how quickly a person’s body is aging at a cellular level, independent of their chronological age. The study revealed that this biological age acceleration partially explains the link between inflammatory diets and CKM syndrome, mediating between 21.43% and 40.00% of the observed effect.

These insights highlight the profound impact of our dietary choices on our long-term health. They suggest that adopting dietary patterns that reduce inflammation could be a vital strategy in preventing and managing cardiovascular-kidney-metabolic syndrome, ultimately leading to better health outcomes.


Source: link to paper