Sirt6 Prevents The Age-Related Decline Of H2S Through The Control Of One-Carbon Metabolism
Ever wonder how some organisms seem to defy the hands of time, living longer and healthier lives? Scientists are constantly uncovering the intricate mechanisms behind healthy aging. One fascinating area of research focuses on a protein known as Sirt6, which has been linked to extended lifespans and improved health.
A recent study sheds light on how this remarkable protein works its magic. It turns out that Sirt6 plays a crucial role in managing a fundamental process in our bodies called “one-carbon metabolism.” Think of this as a vital network of chemical reactions that helps build and maintain our cells.
One of the key players in this metabolic pathway is a tiny gas molecule called hydrogen sulfide (H2S). While it might sound unusual, H2S acts as a “gasotransmitter,” meaning it carries signals and performs important functions, much like hormones do. It’s known to have many beneficial effects, including supporting wound healing, heart health, and brain function. The study found that as we age, our natural levels of H2S tend to drop, reducing these protective benefits. However, Sirt6 steps in to prevent this age-related decline, keeping H2S levels similar to those found in younger individuals.
Additionally, Sirt6 helps regulate another important molecule in this pathway called S-adenosylmethionine (SAM). SAM is a “methyl donor,” essential for many biological processes, including modifying our DNA and proteins. The research shows that Sirt6 prevents the age-related increase of SAM, maintaining its levels in a healthy balance.
By fine-tuning these aspects of one-carbon metabolism—specifically by ensuring healthy levels of H2S and SAM—Sirt6 essentially mimics some of the beneficial effects of “caloric restriction,” a dietary approach known to extend lifespan. This discovery reveals a fundamental way Sirt6 contributes to healthy longevity, offering new avenues for understanding and potentially promoting healthier aging.
Source: link to paper