Circherc1-A Telomerase Activator
Our bodies contain protective caps on the ends of our chromosomes called telomeres, which naturally shorten as we age and our cells divide. This shortening is a key factor in the aging process, as critically short telomeres can cause cells to stop functioning properly, a state known as cellular aging. An enzyme called telomerase is responsible for maintaining these telomeres, but its activity typically decreases with age.
Recent research has uncovered a fascinating molecule, a type of circular RNA, that plays a crucial role in regulating this vital enzyme. This molecule works by binding to a specific region of the DNA, called the promoter, which acts like a switch to turn on the production of a key component of telomerase. As we get older, the levels of this circular RNA naturally decline, leading to reduced telomerase activity and shorter telomeres.
However, when the levels of this circular RNA are restored, it boosts telomerase activity, helps lengthen telomeres, and can even reverse some of the signs of aging. Furthermore, scientists have found ways to deliver this molecule into cells using specialized carriers, which has shown promising results in improving brain function, physical abilities, and reducing inflammation. These findings suggest that targeting this circular RNA could be a powerful new strategy for developing anti-aging therapies.
Source: link to paper