Rutin As A Circadian Modulator Preserves Skeletal Muscle Mitochondrial Function And Reduces Oxidative Stress To Protect Against D-Galactose-Induced Aging In Vitro And In Vivo
As we age, our muscles can experience a decline in function, characterized by issues like impaired muscle cell development, disruptions in our natural daily rhythms (circadian rhythms), increased cellular damage from unstable molecules called oxidative stress, and a decrease in the efficiency of mitochondria, the powerhouses of our cells. These factors contribute to the overall aging of skeletal muscle. Researchers have been exploring natural compounds that might help mitigate these effects. One such compound, a natural plant-derived substance, has shown promising results.
In laboratory studies using muscle cells, this compound was found to restore the ability of muscle cells to form properly. It also helped to re-establish healthy circadian rhythms in genes important for muscle development and corrected imbalances in key “clock” genes. Furthermore, it significantly reduced harmful oxidative stress by decreasing reactive oxygen species and boosting the activity of beneficial antioxidant enzymes. The compound also improved the cells’ energy production and reduced the aging of mitochondria.
Moving from lab dishes to living organisms, studies in animal models of aging demonstrated that supplementing with this compound enhanced muscle performance and improved the muscles’ capacity to utilize oxygen, particularly during their active periods. It also normalized the rhythmic expression of core circadian clock genes in muscle tissue. These findings suggest that this natural compound could be a valuable strategy to combat age-related muscle decline and sarcopenia, a condition characterized by progressive muscle loss and weakness.
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