Long-Term Senolytic Treatment Prevents Endothelial Dysfunction In Arterial Aging
As we age, our bodies accumulate ‘senescent cells,’ often called ‘zombie cells,’ which stop dividing but don’t die. Instead, they release harmful substances that contribute to various age-related problems. A recent study explored how targeting these cells could impact the aging of our arteries. The research found that a long-term treatment designed to clear these senescent cells significantly improved the health and function of blood vessels in older subjects. This treatment helped prevent ‘endothelial dysfunction,’ a condition where the inner lining of blood vessels doesn’t work properly, which is a key factor in ‘arterial aging’ and cardiovascular diseases. Specifically, the treatment reduced markers of these ‘zombie cells’ and helped restore the proper function of an important enzyme called eNOS, which is vital for blood vessel relaxation. When eNOS malfunctions, it can lead to problems like reduced blood flow. The treatment also improved the function of mitochondria, the tiny powerhouses within our cells, which tend to become less efficient with age. By clearing out these problematic senescent cells, the study demonstrated that it’s possible to restore healthy blood flow and improve overall arterial function, offering a promising new approach to combat age-related vascular issues.
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