Edaravone Protected From D-Galactose-Induced Cell Senescence Via Reduction Of DNA Damage And Downregulation Of P53, P21 And P16 Genes In Pc12 Cells
Our cells, like everything else, age over time, a process scientists call “cellular senescence.” This cellular aging is a significant factor in many age-related conditions, including neurodegenerative diseases that affect the brain and nervous system. Researchers often study this process by inducing premature aging in cells, for example, using a sugar called D-galactose, which can cause cells to age faster and accumulate damage.
A recent investigation focused on a drug called Edaravone, known for its ability to combat oxidative stress and inflammation. The study explored whether this drug could protect a type of nerve cell, known as PC12 cells, from the aging effects induced by D-galactose.
The findings revealed that Edaravone effectively shielded these nerve cells. It achieved this by reducing DNA damage, which is a hallmark of aging, and by lowering the activity of specific genes—p53, p21, and p16—that are known to play crucial roles in triggering and maintaining cellular senescence. This suggests that Edaravone could potentially be a valuable compound in strategies aimed at protecting cells from aging and related damage.
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