Negative Association Of C-Reactive Protein-Albumin-Lymphocyte Index (CALLY Index) With All-Cause And Cardiovascular Mortality In Population With CKD: The Mediating Role Of Biological Age Acceleration

A higher C-reactive protein-albumin-lymphocyte (CALLY) index is associated with a lower risk of death from all causes and cardiovascular disease in people with chronic kidney disease, with biological age acceleration partially explaining this relationship.

Researchers have uncovered a significant link between a simple blood-test-derived score and the health outcomes of individuals living with chronic kidney disease (CKD). This score, which combines measures of inflammation (C-reactive protein), nutritional status (albumin), and immune function (lymphocyte count), appears to be a valuable indicator of risk. The study found that a higher value of this combined index was associated with a reduced risk of dying from any cause, as well as specifically from cardiovascular disease, in people with CKD. Interestingly, a portion of this protective effect can be attributed to what scientists call “biological age acceleration.” This refers to how much older or younger a person’s body appears to be functioning compared to their actual chronological age. The findings suggest that this readily available index could be a useful tool for doctors to assess risk and potentially guide interventions for patients with chronic kidney disease.

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