Sex- And Age-Specific Inverted U-Shaped Links Between Dietary Iron Intake And Serum Α‑Klotho In Chinese Adults

Aging Pathway
Lever
Analytical
A study in Chinese adults revealed an inverted U-shaped relationship between dietary iron intake and levels of α-Klotho, a protein associated with anti-aging, with this pattern being more pronounced in women and individuals under 60 years old.
Author

Gemini

Published

December 4, 2025

Scientists are constantly exploring factors that influence our body’s natural defenses against aging. One such factor is a protein called α-Klotho, often referred to as an “anti-aging protein” due to its protective effects against age-related decline and diseases. Recent research has shed light on how our diet, specifically iron intake, might play a role in maintaining healthy levels of this important protein.

The study found a fascinating “inverted U-shaped” connection between the amount of iron consumed and α-Klotho levels. This means that having too little iron or too much iron could be less beneficial for α-Klotho than having a moderate amount. Imagine a hill: α-Klotho levels are highest at the peak, representing a balanced iron intake, and decline on either side if iron intake is too low or too high.

Interestingly, this pattern was particularly noticeable in women and in adults under the age of 60. This suggests that maintaining an optimal iron intake might be especially important for these groups to support their α-Klotho levels. While more research is needed to confirm these findings and understand the underlying mechanisms, this study highlights the potential importance of balanced nutrition, particularly iron, in supporting our body’s anti-aging processes.


Source: link to paper