Myokines In Aging: A Multi-Organ Network Perspective

Skeletal muscles, through the release of signaling molecules called myokines during exercise, communicate with various organs throughout the body to combat the aging process by regulating inflammation, metabolism, and maintaining tissue health.

Did you know that your muscles do more than just help you move? When you exercise, your skeletal muscles act like tiny pharmacies, releasing special signaling molecules called “myokines” into your bloodstream. These myokines are crucial for communication between your muscles and other organs, creating a vast network that influences your entire body. This intricate communication system helps coordinate the many positive changes that come with physical activity. For instance, these muscle-derived factors play a significant role in counteracting the effects of aging across multiple bodily systems, including your metabolism, heart and blood vessels, bones and joints, nervous system, and immune system. They achieve this by tackling key aging-related issues such as persistent, low-grade inflammation (which is like a constant, low-level fire in your body), problems with how your body uses energy (metabolic dysregulation), and the breakdown of your body’s ability to maintain a stable internal environment (loss of tissue homeostasis). Understanding this multi-organ network opens up exciting possibilities for developing personalized exercise plans and new therapies based on myokines to promote healthier aging.

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