Age-Varying DNA Methylation Patterns Associated With Blood Pressure Across The Lifespan
Our bodies are incredibly complex, and understanding how different factors contribute to our health over time is a major challenge. For a long time, scientists have known that our genes and environment play a role in conditions like high blood pressure. More recently, attention has turned to “epigenetics,” specifically DNA methylation, which are chemical tags on our DNA that can turn genes on or off without changing the underlying genetic code. These tags are influenced by both our genes and our lifestyle.
Many studies looking at the link between these DNA tags and blood pressure have only taken a snapshot in time. But what if these relationships change as we age? A recent study tackled this question by following individuals over many years, rather than just looking at them once. This longitudinal approach allowed researchers to see how the connection between DNA methylation patterns in blood and blood pressure evolved throughout a person’s life.
The findings were quite revealing. The study identified specific locations on our DNA where methylation patterns showed significant age-dependent associations with blood pressure. Interestingly, some of these patterns even demonstrated a “reversal of effect” with advancing age. This means that a particular methylation pattern might be linked to higher blood pressure in younger adults but to lower blood pressure later in life. These dynamic changes likely reflect the complex processes of systemic and vascular aging.
By understanding these age-varying relationships, we gain crucial insights into the biological mechanisms behind age-related cardiovascular risk. The research also pinpointed potential drug targets, which could pave the way for new treatments or improved biomarkers to predict and manage heart health as we get older. This work highlights the importance of studying biological processes over time to truly understand their impact on our health.
Source: link to paper