The Role Of MICOS In Modulating Mitochondrial Dynamics And Structural Changes In Vulnerable Regions Of Alzheimer’S Disease
Our cells rely on tiny powerhouses called mitochondria to generate energy. These mitochondria have a complex internal structure, including folds called cristae, which are vital for their efficient operation. A crucial system, known as the mitochondrial contact site and cristae organizing system, or MICOS, acts like an architect, maintaining this intricate internal structure and ensuring proper communication within these powerhouses and with other parts of the cell. As our brain cells age, this architectural system can start to break down. When MICOS integrity is compromised, the mitochondria’s structure becomes disorganized, and their ability to produce energy and function correctly is impaired. This research reveals that such a breakdown makes brain cells more susceptible to the damage observed in conditions like Alzheimer’s disease, affecting their capacity to send signals and respond effectively. Understanding this process highlights the importance of maintaining healthy mitochondrial structure and function as a potential strategy to protect brain cells from age-related decline and neurodegenerative processes.
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