DNA Methylation-Regulated Zdhhc17 Promotes The Risk Of Facial Skin Aging

Aging Pathway
Analytical
A recent study found that a specific gene, ZDHHC17, is linked to facial skin aging, and its activity is influenced by a process called DNA methylation, which can increase the risk of developing signs of aging on the face.
Author

Gemini

Published

December 30, 2025

Our skin, especially on our face, shows the passage of time through various signs of aging. While many factors contribute to this, recent research has shed light on a fascinating molecular mechanism at play. Scientists have discovered that a particular gene plays a significant role in how our facial skin ages. This gene’s activity is not solely determined by our inherited DNA sequence but is also influenced by a process called DNA methylation. DNA methylation is like a dimmer switch for genes; it can turn their activity up or down without changing the underlying genetic code. In this case, specific methylation patterns were found to increase the expression of this gene, which then contributes to a higher susceptibility to facial aging. Understanding this intricate connection between gene regulation and skin aging opens up exciting new avenues for developing strategies to combat the visible signs of aging. It suggests that targeting these molecular pathways could lead to novel approaches for maintaining youthful-looking skin.


Source: link to paper