Eleutheroside B Ameliorates AD-Like Pathological Features In Caenorhabditis Elegans By Inducing Autophagy And Combating Oxidative Stress
Alzheimer’s disease is a growing global health challenge with no current cure. Recent research has explored a natural compound, Eleutheroside B, for its potential therapeutic benefits. Using a tiny worm called Caenorhabditis elegans, a common model in biological research due to its genetic similarities to humans and short lifespan, scientists investigated how this compound might combat Alzheimer’s-like symptoms.
The study found that Eleutheroside B significantly improved cognitive and movement impairments in these worms, and even extended their lifespan. It achieved these effects by tackling key features of Alzheimer’s, specifically by reducing the accumulation of problematic proteins, known as amyloid-beta and tau, which are hallmarks of the disease. Furthermore, the compound appeared to work by boosting the worms’ natural cellular “recycling” process, called autophagy, which helps clear out damaged cell components. It also enhanced the worms’ ability to fight off oxidative stress, a type of cellular damage caused by unstable molecules, by increasing protective enzymes and reducing harmful reactive oxygen species. Importantly, the compound showed no signs of toxicity even at high concentrations. These findings suggest that this natural compound could be a promising candidate for developing new strategies to prevent or treat Alzheimer’s disease.
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