Age-Dependent Reprogramming Of Vascular Metabolism Compromises Endothelial Resilience To Inflammation-Induced Endothelial Dysfunction
Our blood vessels are lined by a crucial layer of cells called endothelial cells, which play a vital role in maintaining healthy blood flow and responding to various signals. When these cells don’t function properly, a condition known as endothelial dysfunction occurs, which is a common feature of both aging and inflammation. This dysfunction can contribute to various health problems.
Recent research has shed light on how aging impacts the energy production, or metabolism, within these endothelial cells. It turns out that as we age, these cells undergo a significant “reprogramming” of their metabolism. In younger vessels, cells might efficiently use different energy pathways to adapt to stress. However, in older vessels, this metabolic flexibility is compromised.
Specifically, studies show that aged blood vessel cells have impaired mitochondrial respiration, which is a key process where mitochondria (the “powerhouses” of the cell) generate most of the cell’s energy. While glycolysis, another energy-producing pathway, might still be active, it doesn’t fully compensate. This shift means that when inflammation strikes, aged blood vessels are less equipped to respond effectively and maintain their normal function. This age-dependent metabolic change makes older blood vessels more susceptible to the damaging effects of inflammation, ultimately contributing to a decline in their overall health and resilience.
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