Bioconverted Red Ginseng Protects Liver Functions And Alters Insulin Homeostasis-Associated Gut Microbiome Composition In Aged Mice
As we age, our bodies undergo various changes, including shifts in liver function and the balance of bacteria in our gut. These changes can contribute to metabolic issues and overall decline. Researchers have been exploring natural compounds that might help mitigate these age-related effects.
One such compound is red ginseng, which has long been recognized for its potential anti-aging properties. A recent study focused on a modified version of red ginseng, created through a special biological conversion process, to see how it impacts older individuals. Using aged mice as a model, the study investigated the effects of this bioconverted red ginseng on liver health, the body’s ability to manage sugar (insulin homeostasis), and the community of microorganisms living in the gut (gut microbiome).
The findings were quite promising. The modified ginseng appeared to protect liver functions, specifically by reducing a condition called cholestasis, which is a decrease in bile flow that can occur with aging. Furthermore, it helped maintain healthy insulin levels, which is crucial for preventing conditions like type 2 diabetes. This was achieved by influencing key signaling pathways in the liver that regulate how the body uses energy.
Perhaps one of the most interesting discoveries was the impact on the gut microbiome. The bioconverted ginseng led to beneficial changes in the gut bacteria composition. It helped reduce the ratio of certain bacterial groups often associated with inflammation and metabolic dysfunction, while increasing the presence of beneficial bacteria. This rebalancing of the gut ecosystem is important because a healthy gut microbiome is increasingly linked to overall well-being and healthy aging.
In essence, this research suggests that this specially processed red ginseng could be a valuable dietary supplement to support healthy aging by simultaneously improving liver health, stabilizing blood sugar regulation, and fostering a balanced gut environment.
Source: link to paper