Α-Klotho Supplementation Mitigates Cumulative Exercise-Induced Fatigue Via Coordinated Nrf2-Mediated Antioxidant Defense And AKT/GS-Driven Hepatic Glycogen Supercompensation In Mice
Feeling drained after a tough workout? New research in mice suggests a fascinating way to combat exercise-induced fatigue. Scientists explored the role of a protein called α-Klotho, often linked to anti-aging, in helping the body recover from strenuous physical activity. They found that giving mice extra α-Klotho significantly reduced their fatigue, prevented weight loss, and improved their grip strength after intense exercise.
So, how does it work? The study revealed two key mechanisms. First, α-Klotho helped reduce “oxidative damage” in muscles, which is like cellular rust caused by unstable molecules called free radicals that build up during exercise. It did this by enhancing the body’s natural “antioxidant defense” system, specifically by activating a pathway known as NRF2/HO-1, which helps cells fight off this damage.
Second, and perhaps even more strikingly, α-Klotho led to a massive increase in sugar storage, called “glycogen,” in the liver—a process the researchers termed “hepatic glycogen supercompensation.” This means the liver was able to store much more readily available energy than usual, which is crucial for sustained physical performance and recovery. This supercompensation was achieved through the activation of the AKT/GS signaling pathway and an increase in GLUT4, a protein that helps transport sugar into cells.
In essence, α-Klotho appears to help the body bounce back from exercise by both protecting cells from damage and ensuring there’s plenty of energy readily available. This dual approach could be a game-changer for understanding and potentially mitigating exercise-induced fatigue.
Source: link to paper