Curcumin Attenuates Pm2.5-Triggered Pulmonary Senescence Via The Mtor/S6K1 Signaling Pathway
Our lungs are constantly exposed to environmental pollutants, and fine particulate matter (PM2.5) is a major concern, contributing to inflammation, oxidative stress, and ultimately, the premature aging of lung cells, known as pulmonary senescence. This cellular aging can lead to a decline in lung function over time.
Recent research has explored potential ways to combat these harmful effects. One promising candidate is a natural compound derived from the turmeric plant, traditionally used for various health benefits. This compound was found to significantly reduce the signs of lung cell aging and improve overall lung function in models exposed to PM2.5. It achieved this by targeting and inhibiting a crucial cellular pathway called mTOR/S6K1, which plays a role in regulating cell growth, metabolism, and aging. By dampening the activity of this pathway, the compound helped to mitigate the damage caused by pollution.
Furthermore, the study observed that this natural intervention also reduced inflammation and oxidative stress, both key contributors to lung damage from PM2.5. These findings suggest that natural compounds could offer a valuable approach to protecting our respiratory health from the adverse effects of air pollution.
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