Human Adipose Stem Cell-Derived Exosomes Modulate The Transcriptome Of D-Galactose-Induced Neuronal Cells
Our brains naturally age, leading to changes that can affect how well our neurological system functions. Scientists are constantly looking for new ways to protect our brains from age-related decline. One promising area of research involves tiny packages released by cells, called exosomes. These particular exosomes come from human adipose (fat) tissue stem cells and have already shown properties that can reduce inflammation and promote rejuvenation.
In a recent study, researchers investigated how these exosomes affect brain cells that were made to mimic aging and neurodegeneration using a sugar called D-galactose. They found that the exosomes significantly altered the activity of many genes within these neuronal cells. Specifically, the exosomes helped to turn down the activity of genes involved in processes like inflammation, cellular aging, and programmed cell death—all of which are linked to age-related brain issues.
This discovery suggests that these stem cell-derived exosomes could potentially be used as a new therapeutic approach to combat the effects of aging on the brain and protect against neurodegenerative conditions.
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