Multi-Omics Analysis Of Human Blood Cells Reveals Unique Features Of Age-Associated Type2 Cd8 Memory T Cells
As we age, our immune system undergoes significant changes, and understanding these shifts is crucial for maintaining health. Recent research has shed light on a particular type of immune cell, known as CD8 memory T cells, and how they evolve with age.
Scientists investigated blood cells from a diverse group of healthy individuals, ranging from young adults to seniors. They discovered a unique population of CD8 memory T cells that become more prevalent as people get older. What makes these cells stand out is their distinct behavior: they lack a specific marker called CXCR3 and produce signaling molecules (cytokines) typically associated with “Type 2” immune responses, which are often involved in allergies and inflammation.
Further analysis revealed that these age-associated cells also exhibit specific changes in their genetic activity and how their genes are regulated (known as epigenetic changes), reinforcing their tendency towards a Type 2 inflammatory profile. This accumulation of these particular CD8 memory T cells was found to be associated with several chronic health conditions, including asthma, chronic liver diseases, and type 2 diabetes.
These findings suggest that the aging process might lead to a subtle but significant shift in our immune system, pushing it towards a more inflammatory state. This “drift” in immune regulation could contribute to the development or worsening of various age-related diseases. The study utilized a comprehensive “multi-omics” approach, meaning they looked at multiple layers of biological information, such as genes, proteins, and epigenetic modifications, to gain a holistic understanding of these complex changes.
Source: link to paper