Klotho Protein And Insulin Resistance
Our bodies rely on a hormone called insulin to help cells absorb sugar from the blood for energy. When cells don’t respond well to insulin, a condition known as insulin resistance develops, which is a key factor in the development of type 2 diabetes. Scientists have been exploring the role of a fascinating protein known as Klotho, often referred to as an “anti-aging” factor, in this process.
Studies reveal that levels of this protein are often lower in individuals with type 2 diabetes. It appears to be intricately involved in how our bodies produce and respond to insulin, influencing insulin secretion, the cellular communication pathways that respond to insulin, and overall insulin sensitivity. For instance, some research suggests a complex relationship where, up to a certain point, higher levels of Klotho might be associated with increased insulin resistance. This could be part of a natural feedback system where insulin itself triggers the release of Klotho, which then helps to regulate or even dampen prolonged insulin activity.
While Klotho can sometimes inhibit insulin’s signals, a deficiency in this protein has been shown to worsen insulin resistance and elevate blood sugar levels. It also seems to play a role in how pancreatic cells, which produce insulin, release it in response to sugar. Understanding these intricate connections could open new avenues for managing diabetes and related conditions.
Source: link to paper