Cellular Senescence As A Therapeutic Target For Aging Intervention
As we age, some of our cells enter a state called “senescence.” These cells stop dividing, but instead of dying off, they linger and can release harmful substances that contribute to inflammation and damage surrounding healthy tissues. This accumulation of senescent cells is now understood to play a significant role in the development of many age-related conditions, from heart disease to neurodegenerative disorders.
Scientists are exploring ways to target these problematic cells as a strategy to combat aging and its associated diseases. One approach involves using “senolytics,” which are compounds designed to selectively eliminate senescent cells. Another strategy uses “senomorphics,” which aim to modify the harmful substances these cells release, reducing their negative impact. Other emerging methods include using the body’s immune system to clear these cells (senescence immunotherapy) or interventions focused on restoring normal cellular function. Early studies, particularly in animal models, have shown promising results, with the removal of senescent cells leading to improved health and lifespan. These findings suggest that by tackling these “zombie cells,” we might be able to prevent or even reverse some aspects of age-related decline, and several human trials are now underway to investigate these potential therapies.
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