Targeting Senescent Cells In Aged Adipose Tissue Induced By Ovarian Cancer With The NF-Κb Inhibitor Quercetin And Resveratrol Impedes The Growth And Metastasis Of Ovarian Cancer
Ovarian cancer is a particularly aggressive disease, often spreading to fatty tissues in the body. Recent research sheds light on a crucial interaction: ovarian cancer cells can actually cause the surrounding fat tissue to age prematurely. This aging process, known as senescence, means that fat cells stop dividing but remain active, releasing inflammatory signals that can inadvertently help the cancer grow and spread.
Scientists discovered that tiny packages released by ovarian cancer cells trigger this aging in fat stem cells, leading to a dysfunctional fat environment and problems with how the body handles sugar. This process involves a specific cellular pathway called NF-κB, which plays a role in inflammation and stress responses.
Crucially, the study found that by targeting these aged, senescent fat cells with certain natural compounds, specifically quercetin and resveratrol, it was possible to improve the health of the fat tissue, normalize sugar metabolism, and significantly reduce the progression and spread of ovarian cancer. This suggests a promising new approach to treating ovarian cancer by focusing on the supportive environment around the tumor.
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