Age-Driven Dysbiosis: Gut Microbiota In The Pathogenesis And Treatment Of Aging Disorders
As we age, the community of microorganisms living in our gut, known as the gut microbiota, undergoes significant changes. This shift, often leading to an imbalance called dysbiosis, plays a crucial role in how our bodies age and can contribute to several health problems.
Research highlights that this age-related gut imbalance can fuel inflammation in the brain (neuroinflammation), contribute to metabolic issues like diabetes, and disrupt the vital communication pathway between our gut and brain, known as the gut-brain axis. This disruption can lead to a decline in brain function and the development of neurological disorders such as Alzheimer’s and Parkinson’s disease.
Understanding these connections is key to finding new ways to promote healthy aging. Scientists are exploring how targeting the gut microbiota, for example through innovative therapies like fecal microbiota transfer, could help restore a healthy balance and potentially treat or prevent these age-related conditions. This involves introducing beneficial microbes from a healthy donor to re-establish a diverse and functional gut environment.
Source: link to paper