Sirt3-Dependent Enhancement Of Apelinergic Signaling Mediates The Cardioprotective Effects Of Late-Life High-Intensity Interval Training
As we age, our hearts can become more vulnerable to various issues. However, new research sheds light on a promising way to keep our hearts healthy even in later life: high-intensity interval training, or HIIT. HIIT involves short, intense bursts of exercise followed by brief recovery periods, and it’s gaining recognition for its powerful health benefits.
This study reveals that engaging in HIIT during our later years can have significant protective effects on the heart. It does this, in part, by boosting a crucial communication system within the body known as apelinergic signaling. Think of this as a vital internal messaging service that helps regulate heart health.
Furthermore, the research points to the involvement of a protein called SIRT3, which is found in the mitochondria—the tiny “powerhouses” within our cells responsible for generating energy. It appears that HIIT, through its influence on SIRT3, helps to improve how well these mitochondria function. When mitochondria work better, our heart cells have more energy and are better equipped to handle the stresses of aging.
Essentially, this means that regular, intense exercise, even as we get older, can activate specific internal pathways and proteins that work together to safeguard our heart. Understanding these mechanisms could pave the way for new strategies to prevent and treat age-related heart problems, potentially offering new therapeutic options beyond just exercise.
Source: link to paper