Natural Senotherapeutics In Respiratory Health: Addressing Cellular Senescence, Inflammaging, And Immunosenescence In The Aging Lung
As we age, our lungs become more vulnerable to various diseases. This vulnerability is largely due to three interconnected processes: cellular senescence, inflammaging, and immunosenescence. Cellular senescence refers to cells that have stopped dividing but remain active, releasing harmful substances that contribute to chronic inflammation, a state called inflammaging. Simultaneously, our immune system weakens with age, a process known as immunosenescence, making us more susceptible to infections and less effective at fighting disease. These factors collectively lead to the decline in lung health often seen in older adults. Researchers are exploring natural compounds, termed senotherapeutics, as a potential solution. These compounds work by either eliminating senescent cells or by reducing the harmful substances they release. Examples of such natural compounds include substances like quercetin and curcumin, which are found in various plants. Studies suggest these natural agents can help by reducing inflammation, improving immune function, and combating oxidative stress in the lungs. While promising, further research is needed to determine the best ways to deliver these compounds and ensure their effectiveness and safety in humans for maintaining respiratory health as we age.
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