Hesperidin Supplementation During Alternate Day Fasting Provides Synergistic Effect In Conferring Neuroprotection To Aging Rats
As we age, our brains become more vulnerable to damage, leading to a decline in cognitive function. Recent research has explored strategies to protect the brain from these age-related changes. One promising approach involves combining dietary interventions with natural compounds.
A study investigated the effects of a specific dietary pattern called alternate day fasting (ADF), where individuals alternate between days of normal eating and days of very low calorie intake. This was combined with supplementation of hesperidin, a natural compound found in citrus fruits known for its antioxidant properties.
The findings revealed that rats receiving both alternate day fasting and hesperidin showed significant improvements compared to control groups. This combination led to stronger antioxidant defenses, meaning their bodies were better equipped to fight off harmful molecules that contribute to aging. The rats also experienced less oxidative stress and inflammation, two key factors in brain degeneration. Furthermore, their brain cells showed improved mitochondrial function (the powerhouses of cells) and better overall brain tissue health. The study also observed an increase in the expression of genes related to autophagy, a natural process where the body cleans out damaged cells, further protecting neurons from age-related harm. These results suggest that combining alternate day fasting with hesperidin supplementation could offer a powerful strategy for maintaining brain health as we age.
Source: link to paper