Probiotics And Aging: Impacts On Cognitive Function, Brain-Derived Neurotrophic Factor, Inflammation, And Antioxidant Activity. A Systematic Review And Meta-Analysis
As we age, maintaining sharp cognitive function becomes a growing concern. Recent research has explored the potential role of probiotics, often called “good bacteria,” in supporting brain health through their interaction with our gut. This comprehensive review and analysis of existing studies focused on adults aged 50 and older, investigating how probiotic supplements might impact thinking abilities, a crucial brain protein called brain-derived neurotrophic factor (BDNF), inflammation, and the body’s ability to fight off harmful molecules (antioxidant activity).
The findings suggest that taking probiotic supplements could lead to modest improvements in cognitive function, especially for those already experiencing some cognitive decline. Beyond just thinking skills, these beneficial microbes also appear to influence several key biological markers. They were associated with increased levels of BDNF, a protein vital for the growth and survival of brain cells, and a reduction in inflammatory markers, which are often linked to age-related cognitive issues. Additionally, probiotics seemed to boost the body’s antioxidant defenses, helping to protect cells from damage.
Interestingly, the review noted that probiotics containing multiple strains of bacteria tended to show better results than those with a single strain. While these results are promising, highlighting the exciting connection between our gut and brain, the authors emphasize that more extensive and longer-term studies are needed to fully understand the benefits and how different probiotic types and dosages can best support cognitive health in aging populations.
Source: link to paper