Wharton’S Jelly Mesenchymal Stem Cell-Secretome Enhances Skin Rejuvenation Via Apoa4 And Serpinh1
Our skin constantly battles the effects of aging, from natural processes to environmental damage like sun exposure and pollution. Researchers are exploring innovative ways to combat these effects, and one promising area involves harnessing the power of “secretomes” – the beneficial molecules released by certain types of stem cells. Think of it as a natural cocktail of regenerative factors.
This new research focuses on stem cells found in Wharton’s jelly, a substance within the umbilical cord. These particular stem cells are known for their strong regenerative abilities. Scientists compared the secretome from these umbilical cord-derived stem cells with those from other sources, like fat and bone marrow. The findings showed that the umbilical cord stem cell secretome was superior in boosting the activity of “fibroblasts,” which are crucial skin cells responsible for producing collagen and other vital components that give skin its structure and elasticity.
Specifically, this secretome enhanced the skin’s ability to rebuild its structural network, increased the production of a key collagen precursor, and significantly reduced factors that cause inflammation and cellular damage. The study identified two specific proteins, ApoA4 and SERPINH1, as major contributors to these rejuvenating effects. In a preliminary human study, applying this secretome topically led to noticeable improvements in skin hydration and elasticity within just one week, with no adverse reactions. This suggests a potential new cell-free approach for skin regeneration, offering the benefits of stem cell therapy without directly using the cells themselves.
Source: link to paper