Buyang Huanwu Decoction Attenuates Vascular Aging By Suppressing The Pathway Of Neutrophil Extracellular Trap Formation Via Modulation Of The Hmgb1/Tlr4/P38 Signaling Pathway
Our blood vessels naturally age, becoming stiffer and less efficient over time, which can lead to serious heart and brain conditions. A key factor in this aging process is an overactive immune response involving tiny web-like structures called neutrophil extracellular traps, or NETs. While NETs are normally helpful in fighting off infections, too many of them can cause inflammation and damage to our blood vessels.
Recent research has shed light on how a traditional Chinese medicine formula, widely used for cardiovascular and cerebrovascular diseases, can combat this issue. The study found that this herbal blend works by calming down the excessive formation of these NETs. It does so by targeting a specific communication pathway within cells, known as the HMGB1/TLR4/p38 signaling pathway. By modulating this pathway, the traditional medicine helps to reduce the harmful effects of NETs on blood vessels.
This discovery suggests a new way to think about treating vascular aging, offering a potential approach that focuses on balancing the immune system to protect our arteries and veins as we get older.
Source: link to paper