Characterizing The SASP-Dependent Paracrine Spreading Of Senescence Between Human Brain Cell Types
Our bodies contain cells that, instead of dying or continuing to divide, enter a state called senescence. These “senescent cells” stop replicating but remain active, often accumulating with age and contributing to various age-related conditions, including those affecting the brain. A key characteristic of these cells is their ability to release a complex mix of molecules, often referred to as a “secretory phenotype.” This molecular cocktail can influence nearby healthy cells, sometimes causing them to also become senescent, a process known as paracrine spreading. This research focused on understanding how this spreading occurs specifically within the human brain, examining different brain cell types. By profiling the unique features of these secretions and how they interact with neighboring cells, scientists were able to pinpoint specific molecular pairs—like a lock and key—that are crucial for transmitting this senescent state. Importantly, the study demonstrated that by targeting these specific molecular interactions with inhibitors, it is possible to prevent the spread of senescence between brain cells. This discovery opens new avenues for potential therapeutic interventions aimed at combating age-related brain dysfunction and neurodegenerative diseases by interrupting this harmful cellular communication.
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