Stevioside Extends The Healthspan And Improves Alzheimer’S Disease And Increases Oxidative Stress Resistance Via The Mitochondrial Unfolded Protein Response
Scientists are constantly exploring natural compounds for their potential health benefits. One such compound, stevioside, a zero-calorie sweetener derived from the Stevia plant, is already known for its various positive effects, including anti-diabetic and anti-inflammatory properties. Recent research has now shed light on its exciting role in combating aging and neurodegenerative diseases.
A new study, primarily conducted on C. elegans (a type of roundworm often used in aging research), revealed that stevioside significantly extended both the lifespan and “healthspan” – the period of healthy life – of these organisms. This beneficial effect was found to be mediated through the activation of a crucial cellular process called the mitochondrial unfolded protein response (UPRmt). Mitochondria are often referred to as the “powerhouses” of our cells, and UPRmt acts as a quality control system, helping these powerhouses cope with stress and maintain their proper function.
Intriguingly, the study also demonstrated that stevioside improved symptoms related to Alzheimer’s disease in the C. elegans model, again by activating the same UPRmt pathway. Furthermore, stevioside enhanced the worms’ ability to resist oxidative stress, a type of cellular damage caused by harmful molecules, and boosted the activity of natural antioxidants within their bodies. Since oxidative stress is a known contributor to both aging and conditions like Alzheimer’s disease, these findings suggest that stevioside could be a promising candidate for developing new strategies to promote healthy aging and address age-related diseases by supporting mitochondrial health.
Source: link to paper