Circadian Rhythms, Nrf2 Signalling And Redox Homeostasis: A Holy Grail For A Healthy Life Course?
Our bodies operate on a roughly 24-hour cycle, known as the circadian rhythm, which influences everything from sleep to metabolism. This internal timing system works in close concert with a vital cellular defense mechanism called NRF2. NRF2 is like a master switch that turns on genes responsible for protecting our cells from damage, particularly from a process called oxidative stress, which is an imbalance between harmful free radicals and antioxidants in the body. Think of oxidative stress as rust forming on metal; too much of it can damage our cells and contribute to aging and disease.
This research highlights a crucial, two-way relationship: our circadian clocks influence how and when NRF2 is active, thereby shaping our body’s ability to fight off damage and manage its energy. Conversely, NRF2 also helps keep our internal clocks running smoothly. When this delicate balance is disrupted—perhaps by irregular sleep, constant exposure to artificial light, or unhealthy eating patterns—it can lead to increased oxidative stress and a weakened ability to adapt to daily challenges. This misalignment can accelerate health decline and increase the risk of various chronic conditions, including metabolic disorders, heart and lung diseases, neurodegenerative conditions, and even cancer. Understanding and maintaining the harmony between our body clocks, NRF2 activity, and cellular balance is therefore presented as a key strategy for promoting health throughout our lives.
Source: link to paper