Natural Modulators Of Enhancer Of Zeste Homolog 2 (Ezh2): Potential Epigenetic Regulators Of Aging-Associated Pathways
Our bodies are incredibly complex, and one key player in how our cells age is a protein called EZH2. For a long time, EZH2 was mainly studied for its role in cancer, where it can sometimes be overactive. However, new research suggests that its role in aging is much more nuanced. Think of EZH2 as a conductor for our genes, influencing which ones are turned on or off through a process called epigenetics—changes to our DNA that don’t alter the genetic code itself but affect how it’s read.
This new perspective highlights that both too much and too little EZH2 activity can contribute to cellular aging, where cells stop dividing and can even harm surrounding tissues. This means that simply blocking EZH2 with strong drugs, as might be done in cancer treatment, might not be the best approach for age-related conditions. Instead, the focus is shifting towards a more delicate adjustment of EZH2 activity, potentially using compounds found in nature. These natural substances could help restore a healthy balance in our epigenetics, allowing our cells to function better as we get older without disrupting other vital processes. Understanding how EZH2 works in different tissues and at various stages of aging is crucial for developing new, safer ways to promote healthy longevity.
Source: link to paper