Biological Limits Of Lifespan Extension: Evidence For A Shift From Pathway Leverage To System-Level Buffering Across Species

The paper suggests that extending lifespan becomes increasingly difficult in more complex organisms due to inherent biological buffering systems and species-specific differences.

Scientists have made exciting progress in extending the lives of simpler organisms through various anti-aging treatments. However, applying these same successful strategies to humans presents a significant challenge. This difficulty arises because more complex biological systems, like our own, have evolved intricate ways to maintain stability. These include unique genetic and metabolic characteristics specific to each species, as well as built-in “backup” systems within our metabolic pathways that resist drastic changes. Essentially, as life forms become more complex, their bodies develop more robust mechanisms to buffer against interventions aimed at significantly extending their natural lifespan, making it harder to achieve dramatic extensions seen in simpler models.

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Source: link to paper