Aging Research News Feed

Click on a title to read the full post.

 

A Glucose Time In Range Of 70% Attenuates The Senescence-Inducing And Pro-Inflammatory Effects Of Hyperglycemia

Aging Pathway
Lever

Maintaining blood glucose levels within a healthy range for at least 70% of the time reduces cellular aging and inflammation caused by high blood sugar.

Nov 29, 2025
Gemini
 

A Scalable Step Count-Based Predictor Of Biological Age: Development And Validation Of Moveit! Age In Community-Dwelling Adults And Geriatric Rehabilitation Inpatients

Clock
Analytical

A new method called MoveIt! Age can accurately predict a person’s biological age using only data from wearable step counters, offering a simple and accessible alternative to traditional invasive tests.

Nov 29, 2025
Gemini
 

AMPK Opens The Door To Organelle Memory And Longevity

Aging Theory
Aging Pathway

A recent study reveals that the protein AMPK helps stabilize another protein called NUP50, which then activates genetic processes that promote fat breakdown and contribute to a longer lifespan.

Nov 29, 2025
Gemini
 

Antioxidant And Anti-Aging Effects Of Quercetin 3-O-Rhamnoside Isolated From Houttuynia Cordata Thunb Extract On Caenorhabditis Elegans

Therapeutic
Aging Pathway

A compound called quercetin 3-O-rhamnoside, isolated from Houttuynia cordata Thunb extract, demonstrated significant antioxidant and anti-aging effects in Caenorhabditis elegans, including extended lifespan and improved stress resistance.

Nov 29, 2025
Gemini
 

Causal Effects Of Immune Cell Populations On Biological Aging: A Mendelian Randomization Study

Aging Pathway
Therapeutic
Analytical

A study using genetic data has identified specific types of immune cells that can causally influence the speed at which a person biologically ages, suggesting potential targets for interventions to slow down aging.

Nov 29, 2025
Gemini
 

Control Of Aging-Associated Neurodegeneration Via Hypothalamic Extracellular Vesicles Containing Parathymosin

Aging Pathway
Therapeutic

A recent study reveals that a protein called parathymosin, delivered by tiny cellular packages from the hypothalamus, plays a crucial role in protecting brain cells from age-related damage and can extend lifespan.

Nov 29, 2025
Gemini
 

Deciphering The Nexus Of Aging And Pan-Cancer: Single-Cell Sequencing Reveals Microenvironmental Remodeling And Cellular Drivers

Aging Theory
Aging Pathway
Analytical
Therapeutic

Aging significantly contributes to cancer development by altering the tumor microenvironment through the accumulation of senescent cells and the weakening of anti-tumor immunity.

Nov 29, 2025
Gemini
 

Dehydroepiandrosterone Opposes Cardiac Aging Via Nfκb/IL-10/Sirt1/Nrf2 Mediated Pathway In Aged Rats

Aging Pathway
Therapeutic

Dehydroepiandrosterone (DHEA) supplementation in aged rats improved heart function, reduced inflammation and oxidative stress, and activated protective genes, suggesting it could help counter age-related decline in cardiac health.

Nov 29, 2025
Gemini
 

Diabetic Kidney Disease And Aging: Focus On Gut Microbiota

Aging Theory
Aging Pathway
Therapeutic

An imbalance in the community of microorganisms residing in the gut is a crucial factor in the development and progression of diabetic kidney disease, especially as people age.

Nov 29, 2025
Gemini
 

Does Polypharmacy Affect Epigenetic Aging In Older People? Evidence From A Longitudinal Epigenome-Wide Methylation Study

Clock
Analytical
Aging Pathway

Taking multiple medications, known as polypharmacy, is associated with accelerated biological aging and changes in how genes are regulated in older individuals.

Nov 29, 2025
Gemini
 

Dysregulation Of Transcription Networks Regulating Oligodendrogenesis In Age-Related Decline In CNS Remyelination

Aging Pathway
Analytical

The study identified specific gene regulatory networks and transcription factors that are disrupted with age, contributing to the reduced ability of the central nervous system to repair myelin, a process crucial for neurological function and often impaired in diseases like multiple sclerosis.

Nov 29, 2025
Gemini
 

Enhancer Rewiring Orchestrates Inflammation And Loss Of Cell Identity During Muscle Stem Cell Aging

Aging Theory
Aging Pathway
Analytical

During aging, muscle stem cells experience changes in their genetic regulation, leading to increased inflammation and a loss of their specialized identity, which impairs the muscle’s ability to regenerate.

Nov 29, 2025
Gemini
 

Fibroblast Growth Factor Signaling Induces A Chondrocyte-Like State Of Peripheral Nerve Fibroblast During Aging

Aging Pathway
Analytical
Therapeutic

A recent study found that increased signaling from fibroblast growth factors, originating from fat cells, causes peripheral nerve fibroblasts to adopt a cartilage-like state during aging, contributing to age-related nerve changes.

Nov 29, 2025
Gemini
 

Immune Age, Cardiovascular Disease, And Anti-Viral Immunity

Aging Theory
Aging Pathway

Aging of the immune system, characterized by declining immune function and chronic inflammation, contributes to both increased susceptibility to severe viral infections and the development of cardiovascular diseases.

Nov 29, 2025
Gemini
 

Interleukin-17F Induces Ischemic Injury In Aged Mice By Causing Endothelial Cells’ Senescence And Dysfunction

Aging Pathway
Therapeutic

Elevated levels of Interleukin-17F are linked to increased severity of peripheral arterial disease and cardiovascular issues in older individuals, by causing premature aging and impaired function of blood vessel lining cells.

Nov 29, 2025
Gemini
 

Losing The Filter: How Kynurenine Pathway Dysregulation Impairs Habituation

Aging Theory
Aging Pathway
Therapeutic

Dysregulation of the kynurenine pathway, particularly through the enzyme KMO, is a key driver of age-related deficits in habituation, and inhibiting KMO can help preserve this cognitive function.

Nov 29, 2025
Gemini
 

Mechanical Stretch Prevents Senescence-Associated Osteogenic Impairment In Mesenchymal Stem Cells Via Cxcr4/Pi3K/AKT Signaling

Aging Pathway
Lever

Mechanical stretch can prevent the age-related decline in the ability of stem cells to form new bone by activating a specific cellular pathway.

Nov 29, 2025
Gemini
 

Metabolomic Investigation Of Myelodysplastic Syndromes, Multiple Myeloma, And Homozygous Β-Thalassemia

Aging Pathway
Therapeutic

This review summarizes current knowledge on metabolic changes in myelodysplastic syndromes, multiple myeloma, and homozygous β-thalassemia, identifying potential new targets for treatment.

Nov 29, 2025
Gemini
 

Methylglyoxal-Induced Glycation Stress Promotes Aortic Stiffening: Putative Mechanistic Roles Of Oxidative Stress And Cellular Senescence

Aging Theory
Aging Pathway
Therapeutic
Analytical

Methylglyoxal-induced glycation stress directly contributes to aortic stiffening by promoting oxidative stress and cellular senescence, and these effects can be mitigated by a glycation stress-lowering compound.

Nov 29, 2025
Gemini
 

Oocyte Age-Dependent DNA Damage Can Be Reverted By The DNA Repair Competent Karyoplasm Of Young Oocytes

Aging Theory
Aging Pathway
Therapeutic

Age-related DNA damage in oocytes, previously considered irreversible, can be significantly reduced and partially reversed by transferring the nucleus of an older oocyte into the cytoplasm of a younger oocyte.

Nov 29, 2025
Gemini
 

Phenotypic And Metabonomics Studies Of Fmos In C. Elegans And Their Roles In Lifespan Extension

Aging Pathway
Analytical

Genetic modifications affecting Flavin-Containing Monooxygenases (FMOs) in C. elegans, specifically the loss of fmo-4 and fmo-3 or overexpression of fmo-2, resulted in elevated tryptophan levels and an extended lifespan.

Nov 29, 2025
Gemini
 

Regional Brain Aging Patterns Reveal Disease-Specific Pathways Of Neurodegeneration

Clock
Analytical

A new deep learning framework can create detailed maps of brain aging, revealing specific patterns of accelerated aging linked to different neurodegenerative diseases like Alzheimer’s, frontotemporal dementia, and schizophrenia.

Nov 29, 2025
Gemini
 

Rutin As A Circadian Modulator Preserves Skeletal Muscle Mitochondrial Function And Reduces Oxidative Stress To Protect Against D-Galactose-Induced Aging In Vitro And In Vivo

Therapeutic
Aging Pathway

Rutin, a natural compound, has been found to protect against skeletal muscle aging by improving the body’s internal clock, reducing cellular damage, and enhancing the function of energy-producing parts within muscle cells.

Nov 29, 2025
Gemini
 

Sex Differences In Behavior, Immune Function, And Redox State Throughout Life, And Their Effect On The Longevity Of Swiss Mice

Aging Theory

Female Swiss mice generally exhibit superior behavior, immune function, and redox balance throughout their lives, which contributes to their longer lifespan compared to males.

Nov 29, 2025
Gemini
 

Tannic Acid Prevents UVB-Induced Skin Photoaging By Regulating Ferroptosis Through Nrf2/Slc7A11/Gpx4 Signaling

Therapeutic
Aging Pathway

Tannic acid effectively prevents skin aging caused by ultraviolet B (UVB) radiation by reducing oxidative stress and a specific type of cell death called ferroptosis, through the activation of a protective cellular pathway.

Nov 29, 2025
Gemini
 

Targeted Clearance Of Senescent Cells Alleviates Alcohol-Associated Liver Disease By Restoring Cellular Function And Immune Balance

Therapeutic
Aging Pathway
Aging Theory

Removing senescent cells, which are aged and dysfunctional cells, can reduce alcohol-associated liver disease by improving liver function and restoring immune balance.

Nov 29, 2025
Gemini
 

The Dynamic Roles Of Repressor Element 1-Silencing Transcription Factor (REST): A Double-Edged Sword In Neural Health And Disease

Aging Pathway
Therapeutic

The Repressor Element 1-Silencing Transcription Factor (REST) plays a dual role in the brain, acting as a protective agent during normal aging but contributing to the pathology of various neurodegenerative diseases.

Nov 29, 2025
Gemini
 

Unraveling The Causal Association Of Epigenetic Age Acceleration With Common Oral Diseases And Its Underlying Mechanisms: Findings From Mendelian Randomization And Integrative Genetic Analysis

Clock
Aging Pathway
Analytical

This study revealed a causal link between accelerated biological aging, as measured by epigenetic clocks, and an increased risk of common oral diseases such as periodontitis, stomatitis, and oral lichen ruber planus.

Nov 29, 2025
Gemini
 

A Glucose Time In Range Of 70% Attenuates The Senescence-Inducing And Pro-Inflammatory Effects Of Hyperglycemia

Aging Pathway
Lever

Maintaining blood glucose levels within the target range for at least 70% of the time significantly reduces cellular aging and inflammation caused by high blood sugar.

Nov 28, 2025
Gemini
 

Antioxidant And Anti-Aging Effects Of Quercetin 3-O-Rhamnoside Isolated From Houttuynia Cordata Thunb Extract On Caenorhabditis Elegans

Therapeutic
Aging Pathway

A natural compound isolated from Houttuynia cordata extract significantly extended the lifespan and enhanced stress resistance in a model organism by boosting antioxidant defenses and modulating aging-related proteins.

Nov 28, 2025
Gemini
 

Blocking Nuclear Receptor Nr4A3 Unlocks The Senescence Barrier To Promote Direct Cardiac Reprogramming

Aging Pathway
Therapeutic

Researchers found that blocking the nuclear receptor Nr4a3 can overcome cellular senescence, a major barrier that limits the ability to directly reprogram other cell types into heart muscle cells, thereby improving heart function after injury.

Nov 28, 2025
Gemini
 

Control Of Aging-Associated Neurodegeneration Via Hypothalamic Extracellular Vesicles Containing Parathymosin

Aging Pathway
Therapeutic

A study has found that a protein called parathymosin, delivered by tiny sacs from the hypothalamus region of the brain, can protect against age-related brain cell damage and extend lifespan.

Nov 28, 2025
Gemini
 

Dehydroepiandrosterone Opposes Cardiac Aging Via Nfκb/IL-10/Sirt1/Nrf2 Mediated Pathway In Aged Rats

Therapeutic
Aging Pathway

Dehydroepiandrosterone (DHEA) supplementation in aged rats improved heart function, reduced inflammation and oxidative stress, and activated protective genes, suggesting it can counteract age-related decline in cardiac health.

Nov 28, 2025
Gemini
 

Does Polypharmacy Affect Epigenetic Aging In Older People? Evidence From A Longitudinal Epigenome-Wide Methylation Study

Clock
Analytical
Aging Pathway

Taking multiple medications, known as polypharmacy, is associated with accelerated biological aging at a molecular level and changes in how genes are regulated in older individuals.

Nov 28, 2025
Gemini
 

Dysregulation Of Transcription Networks Regulating Oligodendrogenesis In Age-Related Decline In CNS Remyelination

Aging Pathway
Therapeutic
Analytical

The study revealed that age-related decline in the brain’s ability to repair myelin is linked to specific changes in the genetic control systems that guide the development of myelin-producing cells.

Nov 28, 2025
Gemini
 

Enhancer Rewiring Orchestrates Inflammation And Loss Of Cell Identity During Muscle Stem Cell Aging

Aging Theory
Aging Pathway
Analytical

Aging muscle stem cells, particularly in males, exhibit increased inflammation and lose their specialized identity due to significant changes in how their DNA is organized and regulated.

Nov 28, 2025
Gemini
 

Fibroblast Growth Factor Signaling Induces A Chondrocyte-Like State Of Peripheral Nerve Fibroblast During Aging

Aging Pathway
Analytical
Therapeutic

A recent study found that signaling from fibroblast growth factors, originating from fat cells, causes peripheral nerve fibroblasts to transform into a cartilage-like state during aging.

Nov 28, 2025
Gemini
 

Immune Age, Cardiovascular Disease, And Anti-Viral Immunity

Aging Theory
Aging Pathway

Aging of the immune system contributes to both increased risk of cardiovascular disease and a reduced ability to fight off viral infections through shared underlying mechanisms.

Nov 28, 2025
Gemini
 

Losing The Filter: How Kynurenine Pathway Dysregulation Impairs Habituation

Aging Theory
Aging Pathway
Therapeutic

Dysregulation of the kynurenine pathway, particularly through the enzyme KMO, drives age-related declines in habituation by promoting neurotoxic processes, and inhibiting KMO can preserve this fundamental learning ability in older mice.

Nov 28, 2025
Gemini
 

Metabolomic Investigation Of Myelodysplastic Syndromes, Multiple Myeloma, And Homozygous Β-Thalassemia

Aging Pathway
Therapeutic

The paper reveals significant alterations in various metabolic pathways, including those related to sugars and fats, in patients with myelodysplastic syndromes, multiple myeloma, and homozygous β-thalassemia compared to healthy individuals.

Nov 28, 2025
Gemini
 

Methylglyoxal-Induced Glycation Stress Promotes Aortic Stiffening: Putative Mechanistic Roles Of Oxidative Stress And Cellular Senescence

Aging Theory
Aging Pathway
Therapeutic

A compound called methylglyoxal, which causes a type of cellular stress, directly contributes to the stiffening of arteries by increasing harmful molecules and causing cells to age prematurely, but a specific intervention can help prevent these effects.

Nov 28, 2025
Gemini
 

Nanoscale Domains Govern Local Diffusion And Ageing Within Fused-In-Sarcoma Condensates

Aging Theory
Aging Pathway
Analytical

Nanoscale domains within biomolecular condensates restrict the movement of RNA and protein molecules, influencing how these condensates age and contribute to neurodegenerative diseases.

Nov 28, 2025
Gemini
 

Nicotine Improves Memory Impairment In Aged Rats Through Enhanced Mitochondrial Homeostasis

Aging Pathway
Therapeutic
Analytical

Nicotine was found to improve recognition memory in aged rats by enhancing the health and function of mitochondria in the hippocampus, a brain region critical for memory.

Nov 28, 2025
Gemini
 

Regional Brain Aging Patterns Reveal Disease-Specific Pathways Of Neurodegeneration

Clock
Analytical

A new deep learning framework, BrainAgeMap, generates detailed maps of brain aging to reveal specific patterns of accelerated aging linked to various neurodegenerative and psychiatric disorders.

Nov 28, 2025
Gemini
 

Sex Differences In Behavior, Immune Function, And Redox State Throughout Life, And Their Effect On The Longevity Of Swiss Mice

Aging Theory

Female Swiss mice generally exhibit superior behavior, immune function, and redox biomarkers throughout their lives, contributing to their increased longevity compared to males.

Nov 28, 2025
Gemini
 

Targeted Clearance Of Senescent Cells Alleviates Alcohol-Associated Liver Disease By Restoring Cellular Function And Immune Balance

Therapeutic
Aging Pathway
Aging Theory

Removing aged, “zombie-like” cells from the liver can reduce damage and improve immune function in alcohol-associated liver disease.

Nov 28, 2025
Gemini
 

Unraveling The Causal Association Of Epigenetic Age Acceleration With Common Oral Diseases And Its Underlying Mechanisms: Findings From Mendelian Randomization And Integrative Genetic Analysis

Clock
Aging Pathway
Analytical

This study found a causal link between accelerated biological aging, as measured by epigenetic clocks, and an increased risk of certain common oral diseases like periodontitis, stomatitis, and oral lichen ruber planus.

Nov 28, 2025
Gemini
 

Unveiling Risk Factors And Predicting Osteoporosis Through Bone Density Based Aging Model: A Community-Based Cohort In Guangdong, China

Clock
Analytical
Lever

A new study identified key risk factors for osteoporosis and developed a bone density-based aging model that can effectively detect deviations in bone health and improve early identification of the condition.

Nov 28, 2025
Gemini
 

Ace1-Targeting Peptide Acein Ameliorates UV-Induced Skin Damage And Aging In Vivo And In Vitro Via Downregulation Of The Pro-Aging Factor Clec4G

Aging Pathway
Therapeutic

A peptide called Acein has been found to reduce skin damage and aging caused by ultraviolet (UV) radiation by targeting a specific protein and decreasing a factor associated with aging.

Nov 27, 2025
Gemini
 

Association Between Cd4+/PD-1+/Cd153+ Cell Infiltration To The Aging Liver And Progression Of Hepatic Steatosis In A Novel MASH Model NI Mouse

Aging Theory
Aging Pathway

A study identified a link between the infiltration of specific immune cells, called CD4+/PD-1+/CD153+ cells, into the aging liver and the worsening of fat accumulation in a new mouse model of metabolic disorder-associated steatohepatitis.

Nov 27, 2025
Gemini
 

Autophagy Is Dispensable In Germline Stem Cells But Is Required In The Cap Cells For Their Maintenance In The Drosophila Ovarian Niche

Aging Pathway

Autophagy, a cellular recycling process, is not essential for the germline stem cells themselves but is required in the surrounding cap cells for the maintenance of the stem cell environment in Drosophila ovaries.

Nov 27, 2025
Gemini
 

Cyclovirobuxine D Ameliorates Cardiomyocyte Senescence In Diabetic Cardiomyopathy Mice By Enhancing Mitochondrial Function Via Sirtuin 3-Atp5O Signal Axis

Aging Pathway
Therapeutic

Cyclovirobuxine D improves the aging of heart muscle cells in diabetic cardiomyopathy by enhancing the function of mitochondria through a specific molecular pathway.

Nov 27, 2025
Gemini
 

Decoding Aging Through Nitrogen Containing Compounds: A Nutrigenomic Insight

Aging Pathway
Lever

Nitrogen-containing compounds are crucial in nutrigenomics, influencing the aging process by modulating gene expression, cellular signaling, and metabolic pathways.

Nov 27, 2025
Gemini
 

Dietary Antioxidants Influence Ier5 Activation And DNA Repair: Implications For Radioprotection And Healthy Aging

Aging Pathway
Therapeutic
Lever

Dietary antioxidants, particularly quercetin and lycopene, can modulate cellular stress responses and contribute to radioprotection by influencing IER5 activation and DNA repair pathways, with their effectiveness depending on specific combinations.

Nov 27, 2025
Gemini
 

Effect Of Aging On The Morphofunctional Characteristics Of Oral Cavity Mesenchymal Stromal Cells: A Scoping Review

Aging Theory
Therapeutic

Aging, particularly after 35 years, negatively impacts the ability of mesenchymal stromal cells from the oral cavity to multiply and transform into other cell types, though their surface markers remain stable.

Nov 27, 2025
Gemini
 

Entropy And Human Aging

Aging Theory
Analytical

Research indicates that entropy, a measure of disorder, is a fundamental aspect of human aging, manifesting as increasing randomness and damage across biological systems and predicting aging-related outcomes like fracture and mortality.

Nov 27, 2025
Gemini
 

Knockout Of Perilipin-2 In Microglia Alters Lipid Droplet Accumulation And Response To Alzheimer’S Disease Stimuli

Aging Pathway
Therapeutic

Removing the protein Perilipin-2 from microglia, which are immune cells in the brain, significantly reduces the accumulation of fat droplets within these cells and improves their ability to clear waste, while also changing how they respond to Alzheimer’s disease-related stimuli.

Nov 27, 2025
Gemini
 

Mitochondrial Dysfunction Drives Age-Related Degeneration Of The Thoracic Aorta

Aging Pathway
Therapeutic

Mitochondrial dysfunction contributes to the age-related stiffening and decline of the thoracic aorta, and improving mitochondrial function may offer a way to counteract this process.

Nov 27, 2025
Gemini
 

New Asperterol From The Coral Associated Fungus Aspergillus Terreus, Which Protects Against UVB Induced Damage Through Antioxidant, Anti-Inflammatory, And Barrier Repair Mechanisms

Aging Pathway
Therapeutic

The specific paper titled “New Asperterol from the coral associated fungus Aspergillus terreus, which protects against UVB induced damage through antioxidant, anti-inflammatory, and barrier repair mechanisms” could not be found in the search results.

Nov 27, 2025
Gemini
 

Novel And Emerging Therapeutic Strategies For Clonal Haematopoiesis

Aging Pathway
Therapeutic

Clonal hematopoiesis, once considered an inevitable part of aging, is now viewed as a potentially modifiable condition with various emerging therapeutic strategies.

Nov 27, 2025
Gemini
 

Pharmacological Investigation Of A Novel Resveratrol-Like Sirt1 Activator Endowed With A Cardioprotective Profile

Aging Pathway
Therapeutic

A novel compound, similar to resveratrol, has been identified as a potent activator of the SIRT1 enzyme and demonstrated protective effects against heart damage in isolated rat hearts.

Nov 27, 2025
Gemini
 

Regulation Of Human Stem Cells By Functional Food Components: How Vitamins, Minerals And Phytochemicals Influence Mesenchymal Stem Cells’ Fate And Function

Lever
Aging Pathway

Vitamins, minerals, and phytochemicals from food play a crucial role in regulating the behavior and function of human mesenchymal stem cells, influencing their growth, aging, immune responses, and ability to regenerate tissues.

Nov 27, 2025
Gemini
 

Senescence: An Overlooked VSMC Phenotype And Therapeutic Opportunity?

Aging Theory
Aging Pathway
Therapeutic

Vascular smooth muscle cells can enter a state of senescence, which is a distinct cellular phenotype contributing to the development of various vascular diseases and represents a potential target for new therapies.

Nov 27, 2025
Gemini
 

Sirtuins As Therapeutic Targets For Treating Cancer, Metabolic Diseases, And Neurodegenerative Diseases

Aging Pathway
Therapeutic

Sirtuins, a family of enzymes, are emerging as promising targets for developing new treatments for a range of conditions including cancer, metabolic disorders, and neurodegenerative diseases due to their diverse roles in cellular health and disease progression.

Nov 27, 2025
Gemini
 

Social Interactions And Cell Aging Dynamics In Postpartum Women

Lever

New research indicates that higher marital satisfaction in new mothers is linked to a greater chance of their cells showing signs of younger biological age.

Nov 27, 2025
Gemini
 

Space-Earth Connection: How Space Weather Fluctuations Impact Epigenetic Aging In An Elderly Men Cohort From Massachusetts, USA

Clock
Analytical
Aging Pathway

Fluctuations in space weather, specifically galactic cosmic rays and solar activity, are linked to changes in the biological aging process in elderly men on Earth.

Nov 27, 2025
Gemini
 

The Antiviral Interferon Pathway Drives Astrocyte Aging And Motor Decline

Aging Pathway
Therapeutic

A specific antiviral immune pathway involving type I interferons drives the aging of brain support cells called astrocytes and contributes to age-related motor decline.

Nov 27, 2025
Gemini
 

The Association Between Early Life Circumstances And Multi-System Biological Aging: A Systematic Review And Meta-Analysis

Analytical
Clock
Lever

Adverse experiences during childhood are linked to a faster rate of biological aging across multiple bodily systems.

Nov 27, 2025
Gemini
 

The Roles Of Glycerophospholipids In The Aging Retina And Age-Related Macular Degeneration

Aging Pathway
Therapeutic

Changes in glycerophospholipids, which are vital components of cell membranes, are strongly linked to the aging of the retina and the development of age-related macular degeneration.

Nov 27, 2025
Gemini
 

Transcriptomic Insights Into The Healthspan-Enhancing Effects Of C. Chinensis Seed And E. Ulmoides Bark Extracts In Caenorhabditis Elegans

Therapeutic
Aging Pathway
Analytical

Research shows that extracts from Cuscuta chinensis seeds and Eucommia ulmoides bark can extend the healthy lifespan and improve stress resistance in Caenorhabditis elegans worms by altering gene activity, with C. chinensis demonstrating broader health benefits and a critical role for the FAR-3 protein in its effects.

Nov 27, 2025
Gemini
 

Unlocking Rejuvenating Potential Of Mesenchymal Progenitor Cells

Aging Theory
Therapeutic

Researchers have engineered human embryonic stem cell-derived mesenchymal progenitor cells to resist cellular aging, environmental stress, and the development of cancer, thereby enhancing their potential for tissue regeneration.

Nov 27, 2025
Gemini
 

A Compound Enhancing Lysosomal Function Reduces Tau Pathology, Microglial Reactivity And Rescues Working Memory In 3Xtg AD Mice

Therapeutic
Aging Pathway

A newly identified natural compound that improves the cell’s waste disposal system has been shown to reduce abnormal tau protein buildup and brain inflammation, and to restore working memory in a mouse model of Alzheimer’s disease.

Nov 26, 2025
Gemini
 

Circherc1-A Telomerase Activator

Aging Pathway
Therapeutic

A recent study identified a circular RNA, circHERC1, as a telomerase activator that can reverse aging-associated phenotypes by promoting telomere elongation.

Nov 26, 2025
Gemini
 

Fermented Porcine Placenta And Its Dipeptides Modulate Cellular Senescence In Human Keratinocytes

Aging Pathway
Therapeutic

Fermented porcine placenta and its dipeptides demonstrate anti-aging effects on human skin cells by improving mitochondrial function and reducing markers associated with cellular aging.

Nov 26, 2025
Gemini
 

Integrated Ecdysone And O-Linked N-Acetylglucosamine Signaling Coordinates Intestinal Stem Cell Proliferation In Drosophila Midgut

Aging Pathway
Therapeutic

This study demonstrates that a steroid hormone and a nutrient-sensitive modification collaboratively regulate intestinal stem cell proliferation in the fruit fly gut, influencing gut health and aging.

Nov 26, 2025
Gemini
 

Ipscs Derived Sevs Ameliorate NK Cell Senescence By Targeting CISH-Stat3

Therapeutic
Aging Pathway
Analytical

Small vesicles released by induced pluripotent stem cells can reverse the aging of natural killer immune cells and enhance their ability to fight tumors by targeting a specific cellular pathway.

Nov 26, 2025
Gemini
 

Mitochondrial Sirtuins Sir-2.2 And Sir-2.3 Regulate Lifespan In C. Elegans

Aging Pathway
Aging Theory

A study revealed that removing the activity of mitochondrial sirtuins sir-2.2 or sir-2.3 in C. elegans worms can extend their lifespan by over 25%.

Nov 26, 2025
Gemini
 

Pim1 Induces Hypoxia-Related Fibroblast Senescence In A Mouse Model Of Stress Urinary Incontinence

Aging Pathway
Therapeutic

The protein PIM1 is a key factor linking low oxygen conditions to cellular aging in fibroblasts, which contributes to stress urinary incontinence in a mouse model, and inhibiting PIM1 shows promise as a treatment.

Nov 26, 2025
Gemini
 

PKA Prevents The Resection Of DNA Double-Strand Breaks And Favours Nonhomologous End-Joining

Aging Theory
Aging Pathway

A protein called PKA helps cells repair broken DNA by promoting a specific repair pathway that directly joins the broken ends, preventing the DNA from being trimmed back.

Nov 26, 2025
Gemini
 

Proteome Organ Aging And Cardiometabolic Risk In A Population At Risk For Heart Failure

Clock
Analytical

Accelerated biological aging in the heart, arteries, and kidneys, as measured by proteins in the blood, is linked to the severity of heart failure, with some differences observed between men and women.

Nov 26, 2025
Gemini
 

RISING STARS: Targeting Premature Cellular Senescence Using Senomorphic Or Senolytic Agents To Impact Diabetes

Aging Theory
Aging Pathway
Therapeutic

Research suggests that targeting senescent cells, which are cells that have stopped dividing and accumulate in the body, could be a promising strategy to prevent and treat type 2 diabetes and its complications.

Nov 26, 2025
Gemini
 

Structural And Functional Impact Of The Pold1 Ser605Del Variant In MDPL Syndrome: Insights From Protein-Protein Interactions

Aging Theory
Aging Pathway
Analytical

A specific genetic variant in the POLD1 protein, linked to MDPL syndrome, impairs its ability to bind DNA and causes an abnormal interaction with the telomeric protein TRF1, contributing to premature aging.

Nov 26, 2025
Gemini
 

Telomerase-Active Urine-Derived Stem Cells: Regenerative Solutions For Aging

Aging Theory
Aging Pathway
Therapeutic

Urine-derived stem cells exhibiting telomerase activity present a promising and non-invasive source for regenerative medicine, offering potential solutions for age-related conditions.

Nov 26, 2025
Gemini
 

Aging And Immunity

Aging Theory
Therapeutic

As people age, their immune system naturally weakens, making them more susceptible to infections and reducing the effectiveness of vaccinations.

Nov 25, 2025
Gemini
 

Association Between Inflammatory Dietary Pattern And Cardiovascular-Kidney-Metabolic Syndrome: A Population-Based Study

Clock
Lever
Analytical

Consuming a diet that promotes inflammation is linked to an increased risk and progression of cardiovascular-kidney-metabolic syndrome, with biological age acceleration playing a mediating role.

Nov 25, 2025
Gemini
 

Association Of Total Fish-Shellfish Consumption With Biological Aging: A Cross-Sectional Analysis Of NHANES 1999-2020 With Mediation By Inflammatory And Antioxidant Biomarkers

Lever
Analytical
Aging Pathway

A recent study found that consuming fish and shellfish is linked to slower biological aging, with fish consumption being the main factor and inflammatory and antioxidant processes playing a mediating role.

Nov 25, 2025
Gemini
 

Azithromycin Mitigates Tobacco Smoke-Induced Lung Senescence By Modulating The Foxo3A/Ccnd1 Signaling Pathway

Aging Pathway
Therapeutic

Azithromycin, an antibiotic, has been found to reduce lung aging induced by tobacco smoke by modulating a specific cellular signaling pathway.

Nov 25, 2025
Gemini
 

Chemical Modulation Of Gut Bacterial Metabolism Induces Colanic Acid And Extends The Lifespan Of Nematode And Mammalian Hosts

Therapeutic
Aging Pathway

A chemical compound can prompt gut bacteria to produce a beneficial substance called colanic acid, which has been shown to extend the lifespan of both worms and mammals.

Nov 25, 2025
Gemini
 

Dental Ageing Offers New Insights Into The First Epigenetic Clock For Common Dolphins (Delphinus Delphis)

Clock
Analytical

Scientists have developed the first epigenetic clock for common dolphins, which can accurately estimate their age using DNA from skin samples, even from deceased animals, and provides new insights into the reliability of dental aging methods.

Nov 25, 2025
Gemini
 

Disruption Of Ovarian Function And Induction Of Apoptosis In Female Mice By Brefeldin A: Mechanistic Insights Into Reproductive Toxicity

Aging Pathway
Analytical

Brefeldin A, a compound that inhibits intracellular transport, was found to disrupt ovarian function, suppress oocyte maturation, and induce programmed cell death in female mice and porcine cells, offering insights into its reproductive toxicity.

Nov 25, 2025
Gemini
 

Expanded Mosaic Chromosomal Alterations, Frailty, And Risks Of All-Cause And Cause-Specific Mortality Among Chinese And The UK Adults: Evidence From Two Prospective Cohorts

Clock
Analytical

Expanded mosaic chromosomal alterations are significantly associated with an increased risk of death from all causes and specific diseases, particularly cancer, independent of an individual’s frailty level.

Nov 25, 2025
Gemini
 

Histone Lactylation As An Epigenetic Regulator In Alzheimer’S Disease Pathophysiology: A Narrative Review

Aging Pathway
Therapeutic

Histone lactylation, a recently discovered modification, is emerging as a significant factor in the development and progression of Alzheimer’s disease by influencing gene regulation and cellular processes.

Nov 25, 2025
Gemini
 

Lactylation Of Mtor Enhances Autophagy In Skeletal Muscle During Exercise

Aging Pathway
Lever

Lactate, a molecule produced during exercise, enhances the cellular recycling process known as autophagy in skeletal muscle by modifying a key protein called mTOR.

Nov 25, 2025
Gemini
 

Longitudinal Changes In Epigenetic Measures Over 2 Years: Methodological Implications

Clock
Analytical

Epigenetic measures, especially those using principal component (PC) clocks, demonstrate stability and predictability over a two-year period in healthy older adults, indicating they may not be highly sensitive to short-term biological changes.

Nov 25, 2025
Gemini
 

Machine-Learning Models Based On Histological Images From Healthy Donors Identify Imageqtls And Predict Chronological Age

Clock
Analytical

Machine-learning models can analyze microscopic tissue images from healthy individuals to identify genetic factors influencing tissue appearance and accurately predict a person’s chronological age.

Nov 25, 2025
Gemini
 

Measurement Of Oxidative Stress To Allow The Development And Use Of New Therapies In Lower Urinary Tract Dysfunction: ICI-RS 2025

Aging Pathway
Therapeutic

The paper highlights that oxidative stress plays a significant role in the development of various lower urinary tract dysfunctions and explores potential biomarkers and therapeutic strategies.

Nov 25, 2025
Gemini
 

Mid- And Late-Life Cardiovascular Health Indicators And Changes In Biological Ageing Markers; A Multi-Cohort Study

Clock
Lever
Analytical

Modifiable cardiovascular risk factors such as smoking, physical inactivity, and poor cardiometabolic health are linked to a faster pace of biological aging, while healthy lifestyle choices are associated with slower aging.

Nov 25, 2025
Gemini
 

Mir-133B-3P Mitigates D-Galactose-Induced Hippocampal Neuron Aging Through Autophagy Regulation Via The MAPK/ERK Signaling Pathway

Aging Pathway
Therapeutic

A specific microRNA, miR-133b-3p, helps protect brain cells in the hippocampus from aging by regulating a cellular recycling process called autophagy through a signaling pathway known as MAPK/ERK.

Nov 25, 2025
Gemini
 

Mirna Changes With Ageing And Caloric Restriction In Male Rat Skeletal Muscle: Potential Roles In Muscle Cell Function

Aging Pathway
Lever
Analytical

Ageing significantly alters the expression of numerous microRNAs in male rat skeletal muscle, and caloric restriction can normalize a substantial portion of these changes, influencing muscle cell function.

Nov 25, 2025
Gemini
 

Mutation In IR Or Igf1R Produces Features Of Long-Lived Mice While Maintaining Metabolic Health

Aging Pathway
Therapeutic

A specific genetic modification in insulin or IGF-1 receptors in mice promotes characteristics of extended lifespan and healthy metabolism without negative side effects on growth or reproduction.

Nov 25, 2025
Gemini
 

Pcbp2 Regulates P16Ink4A-Dependent Cellular Senescence In Response To Iron

Aging Pathway
Therapeutic

A recent study reveals that a protein called PCBP2 controls how cells age and stop dividing, a process known as cellular senescence, in response to iron levels in the body, suggesting a link between iron and age-related diseases like atherosclerosis.

Nov 25, 2025
Gemini
 

Proinflammatory Macrophage-Targeted Nanoparticles Rejuvenate Aged Macrophages And Their Phagocytic Capacity

Therapeutic
Aging Pathway

Scientists have developed specialized nanoparticles that can target and revitalize aged immune cells called macrophages, restoring their ability to clear harmful substances and reduce inflammation.

Nov 25, 2025
Gemini
 

Sirt6 Prevents The Age-Related Decline Of H2S Through The Control Of One-Carbon Metabolism

Aging Pathway

Sirt6 controls a metabolic pathway to prevent the age-related reduction of hydrogen sulfide and the increase of S-adenosylmethionine, thereby promoting healthy longevity.

Nov 25, 2025
Gemini
 

The Biological Scaling Of Alzheimer’S Disease Neuropathological Changes Across Primate Species

Aging Theory
Aging Pathway
Analytical

The study found that amyloid plaques, a hallmark of Alzheimer’s disease, appear in all primate species proportionally to their lifespan, while tau tangles, another hallmark, emerge at a similar chronological age across species, regardless of lifespan.

Nov 25, 2025
Gemini
 

A Senescence-Responsive Nanodrug Amplifies Radiotherapy Efficacy

Therapeutic

A newly developed nanodrug improves the effectiveness of radiation therapy for cancer by specifically targeting and eliminating harmful senescent cells in tumors while reducing treatment side effects.

Nov 24, 2025
Gemini
 

Alleviative Effect Of Stropharia Rugosoannulata Exopolysaccharide On D-Galactose-Induced Gut Inflammation And Oxidative Stress By Modulating Gut Microbiota

Therapeutic
Aging Pathway
Analytical

A specific exopolysaccharide derived from the mushroom Stropharia rugosoannulata was found to reduce gut inflammation and oxidative stress in an aging mouse model by positively altering the gut microbiota.

Nov 24, 2025
Gemini
 

Alterations In Peroxisome-Mitochondria Interplay In Skeletal Muscle Accelerate Muscle Dysfunction

Aging Pathway

Disruptions in the communication and function of peroxisomes and mitochondria within muscle cells contribute to accelerated muscle decline and weakness.

Nov 24, 2025
Gemini
 

Cedrol Prevents UVB-Induced Photoaging By Restoring Mitochondrial Function, Metabolic Homeostasis, And Skin Barrier Integrity In Hacat Cells

Therapeutic
Aging Pathway

Cedrol, a natural compound, has been found to prevent skin damage caused by ultraviolet B (UVB) radiation by improving the function of cellular powerhouses (mitochondria), balancing cell metabolism, and strengthening the skin’s protective barrier.

Nov 24, 2025
Gemini
 

DAF-16/FOXO And HLH-30/TFEB Comprise A Cooperative Regulatory Axis Controlling Tubular Lysosome Induction In C. Elegans

Aging Pathway
Therapeutic

Two key proteins, DAF-16/FOXO and HLH-30/TFEB, work together to promote the formation of tubular lysosomes, which are crucial for maintaining overall health and extending healthy aging in the nematode C. elegans.

Nov 24, 2025
Gemini
 

Genetic Variants In HELB Contribute To Premature Ovarian Insufficiency And Early Age Of Natural Menopause

Aging Pathway
Analytical

Genetic variations in the HELB gene are associated with premature ovarian insufficiency and an earlier onset of natural menopause.

Nov 24, 2025
Gemini
 

Impact Of Psychosocial Stress In Early Life On Pace Of Aging In Young Adulthood

Clock
Lever
Analytical

Exposure to stressful environments during childhood and adolescence is associated with a faster rate of biological aging in young adulthood, and this early-life stress contributes to observed racial differences in aging.

Nov 24, 2025
Gemini
 

Inferring Pathway Activity From Single-Cell And Spatial Transcriptomics Data With Paasc

Analytical

A new computational method accurately infers the activity of biological pathways from single-cell and spatial gene expression data, outperforming existing tools in various applications and across different data types.

Nov 24, 2025
Gemini
 

Iron-Deplete Diet Enhances Caenorhabditis Elegans Lifespan Via Oxidative Stress Response Pathways

Aging Pathway
Lever

An iron-depleted diet extends the lifespan of the roundworm Caenorhabditis elegans by activating specific cellular stress response pathways.

Nov 24, 2025
Gemini
 

Long-Term Exposure To Ultrafine Particles Accelerates Biological Aging And Increases Respiratory Vulnerability In COPD

Clock
Lever
Analytical

Long-term exposure to ultrafine particles accelerates biological aging and worsens respiratory function in individuals with Chronic Obstructive Pulmonary Disease.

Nov 24, 2025
Gemini
 

Meiotic Cohesion Requires Sirt1 And Preserving Its Activity In Aging Oocytes Reduces Missegregation

Aging Pathway
Therapeutic

The protein Sirt1 is essential for proper chromosome separation during egg cell division, and maintaining its activity in older egg cells can reduce errors that lead to developmental problems.

Nov 24, 2025
Gemini
 

Profilin 1 Controls A Microglial Cytoskeleton Checkpoint To Prevent Senescence And Premature Synaptic Decline

Aging Pathway
Therapeutic

A protein called Profilin 1 acts as a crucial control point in brain immune cells, preventing them from aging prematurely and protecting connections between brain cells from declining.

Nov 24, 2025
Gemini
 

Unveiling Nutraceuticals That Modulate Aging Mechanism: Exploring The Intricate Pathways Of Epigenetics

Aging Pathway
Lever

The paper investigates how specific nutrients, known as nutraceuticals, can influence the body’s aging process by modifying epigenetic mechanisms, which are changes in gene activity without altering the DNA sequence itself.

Nov 24, 2025
Gemini
 

A Proposed Path To Explaining The Unexplained Anemia Of Aging

Aging Theory
Aging Pathway
Analytical

The paper proposes a framework for understanding the various contributing factors to unexplained anemia in older adults, aiming to move beyond a diagnosis of exclusion to identify specific mechanisms and potential interventions.

Nov 23, 2025
Gemini
 

Integrative Epidemiological And Spatial Multi-Omics Analyses Reveal Spp1⁺ Macrophages With Senescence-Like Features As Key Mediators Linking No₂ Exposure To Coronary Heart Disease

Aging Pathway
Clock
Lever
Analytical

Exposure to nitrogen dioxide, a common air pollutant, is linked to an increased risk of coronary heart disease through its effect on specific immune cells called SPP1⁺ macrophages, which exhibit features of cellular aging.

Nov 23, 2025
Gemini
 

Emerging And Re-Emerging Viruses As Triggers Of Human Endogenous Retrovirus Activation: Implications For Aging And Age-Related Pathologies

Aging Theory
Aging Pathway

Emerging and re-emerging viruses can trigger the activation of ancient viral remnants in our DNA, called human endogenous retroviruses (HERVs), which contributes to aging and age-related diseases by promoting cellular senescence and chronic inflammation.

Nov 22, 2025
Gemini
 

Fiber Scaffolds Augment Aged Bone Regeneration By Modulating Energy Metabolism, Immunity And Angiogenesis

Therapeutic
Aging Pathway
Analytical

A newly developed fiber scaffold enhances bone regeneration in aged individuals by improving cellular energy production, regulating immune responses, and promoting the formation of new blood vessels.

Nov 22, 2025
Gemini
 

Open Problems In Ageing Science: A Roadmap For Biogerontology

Aging Theory
Therapeutic
Analytical

A recent paper identifies 100 critical unanswered questions in the field of aging and longevity science to guide future research and accelerate progress.

Nov 22, 2025
Gemini
 

Pgk1 Activation Restores Endothelial Metabolic Homeostasis To Alleviate Vascular Aging And Atherosclerosis

Aging Pathway
Therapeutic

Activation of the protein Pgk1 can restore the normal metabolic balance in the lining of blood vessels, thereby reducing the effects of vascular aging and the development of atherosclerosis.

Nov 22, 2025
Gemini
 

Plasma Fatty Acids And The Likelihood Of Healthy Aging: A Prospective Cohort Study

Lever
Analytical
Clock

Higher levels of certain beneficial fats in the bloodstream are associated with a greater likelihood of aging healthily.

Nov 22, 2025
Gemini
 

A Mitochondria-Targeted Fluoropolymer Nanoparticle With Inherent Mitophagy-Inducing And Red Fluorescence Properties For Treatment Of Atherosclerosis

Aging Pathway
Therapeutic

A newly developed fluoropolymer nanoparticle can specifically target damaged mitochondria, induce their removal, and reduce inflammation in cells, offering a promising approach for treating atherosclerosis.

Nov 21, 2025
Gemini
 

A Signature Of Senescence Based On An Analysis Of Selected Markers In Primary Vascular Smooth Muscle Cells Cultured In Vitro And Derived From Atherosclerotic Plaque

Aging Theory
Aging Pathway
Analytical

Researchers identified a set of reliable cellular markers that can consistently identify senescent vascular smooth muscle cells, both in laboratory settings and in cells taken directly from human atherosclerotic plaques.

Nov 21, 2025
Gemini
 

Age‑Dependent And Post‑Intraventricular Hemorrhage Remodeling Of The Ependymal Glycocalyx In Mice

Aging Pathway
Therapeutic
Analytical

The ependymal glycocalyx, a sugar-rich layer lining the brain ventricles, undergoes significant thinning and changes in its sugar composition with aging and is acutely disrupted following intraventricular hemorrhage, contributing to neuroinflammation.

Nov 21, 2025
Gemini
 

Association Of Muscle Mass And Strength With Blood-Based Epigenetic Aging Among Middle-Aged And Older Adults In The United States

Lever
Analytical

A study found that greater muscle mass and strength are associated with a slower biological aging process in middle-aged and older adults.

Nov 21, 2025
Gemini
 

Association Of Telomere Shortening With Low Back Pain And The Potential Mediating Role Of Smoking: A Cross-Sectional Study

Aging Theory
Lever
Analytical

Shorter telomere length is associated with a higher likelihood of experiencing low back pain in older adults, and smoking appears to partially explain this connection.

Nov 21, 2025
Gemini
 

Defining Microbiota-Derived Metabolite Butyrate As A Senomorphic: Therapeutic Potential In The Age-Related T Cell Senescence

Aging Pathway
Therapeutic

A recent study identifies butyrate, a metabolite produced by gut bacteria, as a senomorphic agent that can reduce features of aging in immune cells and offers therapeutic potential for age-related immune decline.

Nov 21, 2025
Gemini
 

Germline Regulation Of The Intestinal Mitochondrial Unfolded Protein Response

Aging Theory
Aging Pathway

The reproductive cells, or germline, play a critical role in regulating how the intestine responds to stress in its mitochondria, which are the cell’s powerhouses.

Nov 21, 2025
Gemini
 

NAD+ Reverses Alzheimer’S Neurological Deficits Via Regulating Differential Alternative RNA Splicing Of Eva1C

Aging Pathway
Therapeutic

A recent study found that increasing levels of the natural molecule NAD+ can reverse neurological problems associated with Alzheimer’s disease by correcting errors in how RNA is processed, specifically through a protein called EVA1C.

Nov 21, 2025
Gemini
 

Resveratrol Attenuates H2O2-Induced Aging And Apoptosis In Mouse Hippocampal Neuron Ht22 Cells By Activating Autophagy Via The Sirt1/Foxo1 Signaling Pathway

Aging Pathway
Therapeutic

Resveratrol protects mouse hippocampal neurons from aging and cell death induced by oxidative stress by activating a cellular self-cleaning process through a specific signaling pathway.

Nov 21, 2025
Gemini
 

Role Of B1 Antisense RNA On The Proliferation And Killing Tumor Ability Of Aged Mouse Spleen Lymphocytes

Aging Pathway
Therapeutic

A study found that B1 antisense RNA can significantly boost the proliferation and tumor-killing capabilities of immune cells from aged mice.

Nov 21, 2025
Gemini
 

The Aging Microenvironment Is A Determinant Of Immune Exclusion And Metastatic Fate In Pancreatic Cancer

Aging Pathway
Therapeutic

The aging of the tissue surrounding pancreatic tumors significantly influences how the immune system responds to the cancer and how likely the cancer is to spread.

Nov 21, 2025
Gemini
 

The Complex Interplay Between Aging, Cardiac Remodeling, And Atrial Fibrillation

Aging Theory
Aging Pathway

Aging significantly increases the risk of developing atrial fibrillation, a common heart rhythm disorder, due to a complex interaction of biological changes in the heart.

Nov 21, 2025
Gemini
 

The Controversial Role Of Senescence-Associated Secretory Phenotype (SASP) In Cancer Therapy

Aging Theory
Aging Pathway
Therapeutic

The senescence-associated secretory phenotype (SASP) plays a complex, dual role in cancer therapy, initially suppressing tumors but potentially promoting their growth, spread, and resistance to treatment over time.

Nov 21, 2025
Gemini
 

Tmtcrunch: A Proteomic Atlas Of Alternative Splicing For Predicting Splicing-Induced Implications In Aging And Alzheimer’S Disease

Analytical
Aging Pathway

Researchers developed a new computational tool to create the first comprehensive map of alternatively spliced proteins in Alzheimer’s disease, revealing numerous previously uncharacterized protein forms.

Nov 21, 2025
Gemini
 

Vascular Niches Are The Primary Hotspots In Cardiac Aging

Aging Pathway
Therapeutic
Analytical

The areas around blood vessels in the heart, known as vascular niches, are identified as the primary locations where age-related damage, inflammation, and scarring accumulate, rather than the heart muscle cells themselves.

Nov 21, 2025
Gemini
 

Associations Of Outdoor Artificial Light At Night Exposure With Telomere Length And Mitochondrial DNA Copy Number In Children And Adolescents: Examining Sex-Specific Associations

Lever
Analytical

Exposure to outdoor artificial light at night is associated with shorter telomere length in children and adolescents, with a more pronounced effect observed in boys, while no significant association was found with mitochondrial DNA copy number.

Nov 20, 2025
Gemini
 

Chameau (Hbo1) Regulates Starvation Resistance In Drosophila Melanogaster In A Temperature-Dependent Manner

Aging Pathway

The gene Chameau (HBO1) is crucial for fruit flies to survive starvation at cooler temperatures, but its importance diminishes at slightly warmer temperatures, where the flies can resist starvation even without it.

Nov 20, 2025
Gemini
 

Chemically Fueled, Active Droplets Prevent The Aging Of Peptides Into Amyloid-Like Fibers

Aging Theory
Aging Pathway
Therapeutic

Scientists have developed chemically fueled, active droplets that can prevent peptides from clumping together into harmful amyloid-like fibers, a process linked to molecular aging and neurodegenerative diseases.

Nov 20, 2025
Gemini
 

Endothelial Lrrc8A Delays Vascular Ageing In Natural And Accelerated Ageing Mouse Models

Aging Pathway
Therapeutic
Analytical

A protein called LRRC8A, found in the inner lining of blood vessels, has been shown to slow down the aging process of blood vessels by influencing key cellular pathways.

Nov 20, 2025
Gemini
 

Fluorescence Lifetime Clocks Quantify Senescence And Aging

Clock
Analytical

A new imaging technique uses specialized fluorescent dyes to visually measure aging and cellular senescence in living systems in real-time, from individual cells to whole organisms.

Nov 20, 2025
Gemini
 

Β-Galactosidase-Targeted Senolytic Prodrug Ameliorates Preclinical Models Of Post-Traumatic Osteoarthritis

Aging Pathway
Therapeutic

A new prodrug, SSK1, effectively and precisely eliminates senescent cells, often called “zombie cells,” in models of post-traumatic osteoarthritis, leading to reduced pain and improved joint health.

Nov 20, 2025
Gemini
 

Metabolic Environment-Driven Remodeling Of Mitochondrial Ribosomes Regulates Translation And Biogenesis

Aging Pathway

The metabolic state of a cell can change the structure and composition of mitochondrial ribosomes, which then adjusts their protein-making activity to match the cell’s energy needs and influences the creation of new mitochondria.

Nov 20, 2025
Gemini
 

Mitochondrial Metabolism Influences Meiotic Maturation In Human Oocytes Of Young And Advanced Maternal Age Women

Aging Theory
Aging Pathway
Analytical

Poor mitochondrial metabolism hinders the maturation of human oocytes, leading to a reduced capacity for oocyte development in women of advanced maternal age.

Nov 20, 2025
Gemini
 

Nuclear-Lamin-Guided Plastic Positioning And Folding Of The Human Genome

Aging Pathway

The study reveals that nuclear lamins are essential for the precise three-dimensional positioning and folding of the human genome, influencing chromosome organization, gene activity, and stem cell function.

Nov 20, 2025
Gemini
 

Oxytocin And The Pace Of Life History Strategies: From Evolutionary Trade-Offs To Translational Pathways

Aging Theory
Lever

Oxytocin influences how organisms allocate energy, promoting slower life history strategies characterized by increased investment in parental care and self-maintenance, particularly in safe environments, while dangerous environments lead to decreased oxytocin signaling and faster life history strategies that prioritize reproduction.

Nov 20, 2025
Gemini
 

Rethinking Muscle Aging Through The Lens Of Fibro-Adipogenic Progenitors

Aging Pathway
Therapeutic

Specialized cells called fibro-adipogenic progenitors (FAPs) shift from supporting muscle repair in younger individuals to promoting fat and fibrous tissue accumulation and hindering regeneration in older individuals, contributing significantly to muscle aging.

Nov 20, 2025
Gemini
 

The Diet-Obesity-Brain Axis: Metabolic, Epigenetic, And DNA-Repair Pathways Linking Eating Patterns To Cognitive Aging, With An AI-Enabled Translational Perspective

Aging Pathway
Lever
Analytical

Unhealthy eating patterns, particularly those high in ultra-processed foods, fats, and sugars, contribute to obesity and metabolic dysfunction, which in turn negatively impact brain health and accelerate cognitive aging through various metabolic, epigenetic, and DNA-repair mechanisms.

Nov 20, 2025
Gemini
 

Accelerated Biological Aging And Its Hallmarks In DNA Methylation Drive The Association Between Unhealthy Lifestyles And The Onset Of Colorectal Cancer

Clock
Analytical
Lever
Aging Pathway

Accelerated biological aging, as indicated by DNA methylation patterns, is linked to an increased risk of colorectal cancer, with unhealthy lifestyles partly driving this association.

Nov 19, 2025
Gemini
 

Adverse Childhood Experiences Patterns And Biological Aging In A Representative Sample Of Older Americans

Clock
Analytical

Adverse childhood experiences are linked to accelerated biological aging and increased depressive symptoms in older Americans, with accelerated aging partially explaining the connection between early adversity and later-life depression.

Nov 19, 2025
Gemini
 

Aging-Related Epigenetic Instability In Lncrnas And Mirnas Mediates The Development Of Hypertension

Aging Pathway
Therapeutic

Aging leads to changes in the regulation of non-coding RNAs, specifically long non-coding RNAs and microRNAs, which contributes to the development of high blood pressure by affecting blood vessel function and inflammation.

Nov 19, 2025
Gemini
 

Ascorbic Acid Attenuates Immunosenescence And Cognitive Decline Via Myh9-Mediated Cd8⁺ T Cell Differentiation

Aging Pathway
Therapeutic

Ascorbic acid, also known as Vitamin C, can improve memory and thinking abilities and reverse age-related decline in the immune system by influencing the development of specific immune cells.

Nov 19, 2025
Gemini
 

Colocalizing Telomeres With PML Or Γh2Ax Foci By IF-FISH In Mouse Brain Neurons

Aging Pathway
Analytical

A new method has been developed to visualize DNA damage and telomere maintenance mechanisms specifically within non-dividing brain neurons.

Nov 19, 2025
Gemini
 

Early Life Functional Advantage Coupled With Accelerated Aging: The Case For Antagonistic Pleiotropy In Huntington’S Disease

Aging Theory
Aging Pathway

The gene responsible for Huntington’s disease may provide early-life brain advantages and superior cognitive function, but this benefit is coupled with accelerated brain aging and decline later in life.

Nov 19, 2025
Gemini
 

Exploring The Causal Relationship Between Telomere Regulation, Aging And Neurological Disorders

Aging Theory
Aging Pathway
Clock
Therapeutic

Research indicates that telomere biology plays a significant role in the aging process and the development of various neurological disorders, with telomere shortening potentially contributing to neurodegeneration, immune system aging, and cerebrovascular issues.

Nov 19, 2025
Gemini
 

Long-Term Exposure To Traffic-Related Air Pollution Is Associated With Epigenetic Age Acceleration

Clock
Lever
Analytical

Long-term exposure to air pollution from traffic is associated with an accelerated biological aging process, particularly in individuals who have previously smoked.

Nov 19, 2025
Gemini
 

Microvascular Health As A Key Determinant Of Organismal Aging

Aging Theory
Therapeutic
Lever
Analytical

The health of the body’s smallest blood vessels is a crucial factor determining how an organism ages and its susceptibility to age-related diseases.

Nov 19, 2025
Gemini
 

Role And Mechanisms Of Plant Polyphenols In Ovarian Aging

Aging Theory
Aging Pathway
Therapeutic

Plant polyphenols demonstrate potential in delaying ovarian aging by mitigating oxidative stress, inflammation, and hormonal imbalances, while also positively influencing gut microbiota.

Nov 19, 2025
Gemini
 

Sulfur Amino Acids, Metabolic Health And Beyond: Recent Advances, Translational Implications, And Future Research Considerations

Aging Pathway
Lever

Dietary restriction of sulfur amino acids, specifically methionine and cysteine, has been shown to delay disease onset and the aging process, and improve metabolic health in various experimental models.

Nov 19, 2025
Gemini
 

The Bud31 Homologous Gene In Schizosaccharomyces Pombe Is Evolutionarily Conserved And Can Be Linked To Cellular Processes Regulated By The TOR Pathway

Aging Pathway
Analytical

The BUD31 homologous gene in fission yeast, Schizosaccharomyces pombe, is evolutionarily conserved and plays a role in cellular processes regulated by the TOR pathway, offering insights into human diseases like cancer.

Nov 19, 2025
Gemini
 

The M6A Demethylase FTO Links Tlr7 To Mitochondrial Oxidation Driving Age-Associated B Cell Formation In Systemic Lupus Erythematosus

Aging Pathway
Therapeutic

A recent study reveals that a protein called FTO, when highly active, promotes the formation of specific immune cells that contribute to the development of systemic lupus erythematosus by disrupting the normal function of cellular powerhouses.

Nov 19, 2025
Gemini
 

The Potential Of Marine-Derived Compounds In Geroscience

Therapeutic
Aging Theory
Aging Pathway

Marine-derived compounds show promise in counteracting the aging process and addressing age-related diseases due to their diverse biological properties.

Nov 19, 2025
Gemini
 

Aged Mice Exhibit Widespread Metabolic Changes But Preserved Major Fluxes

Aging Theory
Aging Pathway
Analytical

Despite widespread changes in individual metabolite levels, the overall rates of major metabolic processes in aged mice remain largely stable.

Nov 18, 2025
Gemini
 

Aging And Corneal Nerve Health: Mechanisms Of Degeneration And Emerging Therapies For The Cornea

Aging Theory
Therapeutic
Lever

Aging causes a progressive decline in the health of corneal nerves, which are essential for eye function, leading to increased vulnerability to various eye conditions, with several factors accelerating this degeneration and new therapies being developed to mitigate it.

Nov 18, 2025
Gemini
 

Cell-Autonomous And Non-Cell-Autonomous Effects Of Arginase 2 On Cardiac Aging

Aging Pathway

A recent study reveals that the enzyme Arginase 2 contributes to heart aging through both direct actions within specific heart cells and indirect communication between different cell types in the heart.

Nov 18, 2025
Gemini
 

Diminished Ceacam1 Level Plays A Critical Role In Age-Related Hepatic Fibrosis

Aging Pathway
Therapeutic

Reduced levels of a protein called CEACAM1 are a key factor in the development of age-related liver scarring.

Nov 18, 2025
Gemini
 

Herbacetin And Gossypetin Glycosides From Sedum Kamtschaticum Fisch. & C. A. Mey. And S. Takesimense Nakai, And Their Antioxidant, Anti-Aging, And Monoamine Oxidase Inhibitory Activities

Therapeutic

Compounds isolated from Sedum kamtschaticum and Sedum takesimense plants, specifically gossypetin and herbacetin, demonstrated significant antioxidant, anti-aging, and selective monoamine oxidase-B inhibitory activities.

Nov 18, 2025
Gemini
 

Induced Pluripotent Stem Cell-Derived Extracellular Vesicles Prevent Neural Stem Cell Senescence To Promote Cognitive Recovery After Traumatic Brain Injury

Aging Pathway
Therapeutic

Induced pluripotent stem cell-derived extracellular vesicles have been shown to prevent the aging of neural stem cells and improve cognitive function following traumatic brain injury.

Nov 18, 2025
Gemini
 

Ketone Catabolism Is Essential For Maintaining Normal Heart Function During Aging

Aging Pathway
Therapeutic
Lever

The heart relies on the breakdown of ketones for energy to maintain normal function as it ages, and a decline in this process contributes to age-related heart problems.

Nov 18, 2025
Gemini
 

Mitochondrial Complex III-Derived ROS Amplify Immunometabolic Changes In Astrocytes And Promote Dementia Pathology

Aging Pathway
Therapeutic

Mitochondrial complex III in astrocytes generates reactive oxygen species that intensify immunometabolic alterations and contribute to the progression of dementia.

Nov 18, 2025
Gemini
 

Neurophysiological And Neuroinflammatory Adaptations To Seizure Activity In Aging

Aging Pathway
Analytical

Generalized seizures in middle-aged mice lead to long-term spontaneous seizure activity, altered brainwave patterns, and increased neuroinflammation, unlike in younger adults.

Nov 18, 2025
Gemini
 

Ovarian Aging: A Multifaceted Perspective On Mechanisms

Aging Theory
Aging Pathway

Ovarian aging is a complex process driven by a network of mechanisms, with mitochondrial dysfunction serving as a central factor interconnected with genetic, metabolic, and inflammatory pathways.

Nov 18, 2025
Gemini
 

Over-Represented Senescent Keratinocytes In Hyperpigmented Spots Promote Melanocyte Activation Via Igfbp3 And NGF

Aging Pathway
Therapeutic

Aged skin cells, called senescent keratinocytes, found in dark spots on the skin, release specific proteins (IGFBP3 and NGF) that activate pigment-producing cells, leading to increased melanin production and the formation of these spots.

Nov 18, 2025
Gemini
 

SUL-138 Mitigates Accelerated Endothelial Aging And Protects The Kidney

Aging Theory
Aging Pathway
Therapeutic

A compound called SUL-138 has been found to reverse accelerated aging in the lining of blood vessels and protect the kidneys from damage.

Nov 18, 2025
Gemini
 

Targeting Lysosomal Acidification To Restore Microglial Homeostasis And Mitigate Memory Decline During Male Brain Ageing

Aging Pathway
Therapeutic

A common antihistamine, ketotifen, was found to restore the acidity of cellular waste-disposal units in the brains of aged male mice, leading to healthier brain immune cells, reduced inflammation, and improved memory.

Nov 18, 2025
Gemini
 

The Energy Resistance Principle

Aging Theory
Lever

The Energy Resistance Principle proposes that life requires a balanced level of energy resistance to transform energy from food into useful work, with imbalances leading to disease and aging.

Nov 18, 2025
Gemini
 

The Roles Of Eda2R In Ageing And Disease

Aging Theory
Aging Pathway
Clock
Therapeutic
Lever

A recent study identifies the ectodysplasin A2 receptor (EDA2R) as a key regulator and biomarker of aging, demonstrating that its increased expression with age actively promotes inflammation and tissue damage, while its inhibition can lessen these effects.

Nov 18, 2025
Gemini
 

Transcriptomic Analysis Of Mitohormesis Associated With Lifespan Extension In Caenorhabditis Elegans

Aging Theory
Aging Pathway
Analytical

The study investigated the complex molecular regulation of longevity in the nematode Caenorhabditis elegans under various mitochondrial stressors to determine if specific transcriptomic changes correlate with lifespan extension and the mitochondrial unfolded protein response.

Nov 18, 2025
Gemini
 

Vitamin D And The Aging Skin: Insights Into Oxidative Stress, Inflammation, And Barrier Function

Aging Theory
Aging Pathway
Therapeutic
Lever

Vitamin D plays a crucial role in combating skin aging by reducing oxidative stress, controlling inflammation, and maintaining the skin’s protective barrier function.

Nov 18, 2025
Gemini
 

Wheat Germ Active Peptide RPPSFF Alleviates Age-Related Osteoporosis Through The Yy1/AMPK/Sirt1 Pathway

Aging Pathway
Therapeutic

A specific peptide derived from wheat germ, known as RPPSFF, has been found to significantly improve bone formation, reduce bone breakdown, and enhance antioxidant capacity and bone structure in models of age-related osteoporosis.

Nov 18, 2025
Gemini
 

Aging Influences Nucleolar Responses To Traumatic Brain Injury In Drosophila

Aging Theory
Aging Pathway
Therapeutic

Traumatic brain injury causes nucleoli, which are cellular structures, to enlarge in young fruit flies, but this response is absent in older flies, and inhibiting a specific cellular pathway can reduce early mortality after injury.

Nov 17, 2025
Gemini
 

Antipsychotic Polypharmacy And Epigenetic Age Acceleration In Schizophrenia

Clock
Therapeutic
Analytical

The study found some evidence that individuals with schizophrenia spectrum disorders on multiple antipsychotic medications, particularly females, showed a deceleration in their biological aging based on epigenetic markers, and this effect was not related to the medication dose.

Nov 17, 2025
Gemini
 

Cardiorespiratory Fitness And Type 2 Diabetes Risk: A Prospective Cohort Study With Mediation Analysis Of Biological Aging In The UK Biobank

Lever
Clock
Analytical

Higher cardiorespiratory fitness is strongly associated with a reduced risk of developing type 2 diabetes, with biological aging partially mediating this protective effect.

Nov 17, 2025
Gemini
 

Cd300Lf Regulates Neutrophil Aging And Periodontal Immune Homeostasis

Aging Pathway
Therapeutic

A recent study has identified a key immune regulator, CD300lf, which, when its levels are reduced, speeds up the aging process of immune cells called neutrophils, contributing to a common inflammatory gum disease known as periodontitis.

Nov 17, 2025
Gemini
 

Coenzyme Q10 Attenuates Age-Associated Neurodegeneration Via Modulation Of Autophagy And Neuroinflammation In Aged Rats

Therapeutic
Aging Pathway

Coenzyme Q10 supplementation in aged rats demonstrated neuroprotective effects by enhancing antioxidant defenses, restoring mitochondrial function, activating cellular self-cleaning processes, and reducing brain inflammation, ultimately mitigating age-associated neurodegeneration.

Nov 17, 2025
Gemini
 

Elevating Cytosolic NADPH Metabolism In Endothelial Cells Ameliorates Vascular Aging

Aging Pathway
Therapeutic

Researchers found that increasing the levels of a molecule called NADPH in the fluid portion of endothelial cells, which line blood vessels, can help to reverse the effects of vascular aging.

Nov 17, 2025
Gemini
 

Liu Jun Zi Decoction Extends Lifespan And Healthspan Through P16/P21 Signaling In Caenorhabditis Elegans

Therapeutic
Aging Pathway

A traditional Chinese herbal formula called Liu Jun Zi Decoction was found to extend the lifespan and improve various health indicators, such as stress resistance and movement, in a type of worm called Caenorhabditis elegans by influencing specific cellular pathways.

Nov 17, 2025
Gemini
 

Permanent Senescence Via P16 Leads To Guttae Formation In An In Vitro Human Corneal Endothelial Cell Model

Aging Theory
Aging Pathway

The study found that permanently senescent corneal cells, specifically those with elevated p16 protein and arrested in a non-dividing state, contribute to the formation of guttae, which are abnormal deposits in the cornea associated with an eye disease called Fuchs endothelial corneal dystrophy.

Nov 17, 2025
Gemini
 

Revisiting Renin-Angiotensin-Aldosterone System In Aging: Translational Insights From Bench To Bedside And Back

Aging Theory
Aging Pathway
Therapeutic

Aging causes a shift in the body’s blood pressure and fluid regulation system, leading to an increase in harmful components within tissues that contribute to age-related diseases, while protective elements of the system decline.

Nov 17, 2025
Gemini
 

Slowing Down To Take It In: Endocytosis During Cellular Aging

Aging Theory
Aging Pathway

Research indicates that as cells age, an increase in the alkalinity of their internal waste-processing compartments leads to a slowdown in how they absorb materials from their surroundings.

Nov 17, 2025
Gemini
 

Therapeutic Effect Of A Recombinant Human Fibronectin Construct In Skeletal Muscle Repair And Oxidative Stress

Therapeutic
Aging Pathway

A newly developed recombinant human fibronectin construct effectively enhances skeletal muscle repair and provides protection against oxidative stress in animal models of aging and injury.

Nov 17, 2025
Gemini
 

A Unified Framework For Systematic Curation And Evaluation Of Aging Biomarkers

Researchers developed an open-source framework called Biolearn to standardize the evaluation of aging biomarkers, revealing that different biomarkers are optimal for predicting chronological age versus mortality and healthspan.

Nov 16, 2025
Gemini
 

A Versatile Cohesion Manipulation System Probes Female Reproductive Age-Related Egg Aneuploidy

Researchers developed a system to precisely control chromosome cohesion in mouse eggs, revealing that premature chromosome separation, a cause of age-related infertility, dramatically increases only when cohesion proteins fall below a critical level.

Nov 16, 2025
Gemini
 

Aging Represses Oncogenic KRAS-Driven Lung Tumorigenesis And Alters Tumor Suppression

Aging can suppress the initiation and growth of lung tumors driven by the oncogenic KRAS gene and alters the effectiveness of tumor suppression.

Nov 16, 2025
Gemini
 

Altered Nicotinamide Adenine Dinucleotide Metabolism Drives Cartilage Degeneration And Osteoarthritis

A decline in a vital molecule called NAD+ due to increased consumption by an enzyme named PARP14 contributes to cartilage breakdown and the development of osteoarthritis.

Nov 16, 2025
Gemini
 

Chemical Modulation Of Gut Bacterial Metabolism Induces Colanic Acid And Extends The Lifespan Of Nematode And Mammalian Hosts

A chemical approach that modulates gut bacterial metabolism to produce colanic acid has been shown to extend the lifespan of nematode and mammalian hosts.

Nov 16, 2025
Gemini
 

Computational Strategies For Exploring Amino Acids And Peptides As Inhibitors Of Advanced Glycation Endproducts

Computational methods are being utilized to identify and design amino acids and peptides that can inhibit the formation of Advanced Glycation Endproducts (AGEs), which are toxic compounds implicated in various diseases.

Nov 16, 2025
Gemini
 

Dental Ageing Offers New Insights Into The First Epigenetic Clock For Common Dolphins (Delphinus Delphis)

Researchers have developed the first DNA-based “epigenetic clock” for common dolphins, enabling accurate age estimation from skin samples, even from deceased animals, which is vital for conservation efforts.

Nov 16, 2025
Gemini
 

Divergent Effects Of Cytomegalovirus And Rheumatoid Arthritis On Senescent Cd4+ T Cells

Cytomegalovirus infection leads to an increase in aged CD4+ T cells with a cell-killing function, while rheumatoid arthritis primarily impairs the function of these aged cells, especially in individuals also infected with cytomegalovirus.

Nov 16, 2025
Gemini
 

Injectable Glycyrrhizic Acid Hydrogel Microspheres With Synergistic Anti-Senescence And Osteogenic Effects For Osteoporosis Therapy

Researchers developed injectable hydrogel microspheres containing glycyrrhizic acid that effectively promoted bone formation and reduced cellular aging in a mouse model of osteoporosis.

Nov 16, 2025
Gemini
 

Integrated Multiomics Analysis And Mendelian Randomization Identify Sirt1 As A Pivotal Aging-Associated Gene In Meningioma

A recent study identified SIRT1 as a key gene linking aging to the development of meningiomas, suggesting it could be a target for diagnosis and treatment.

Nov 16, 2025
Gemini
 

Long-Read Sequencing Reveals Genomic And Epigenomic Variation In The Dark Genome Of Human Alzheimer’S Disease

Long-read sequencing has revealed significant genomic and epigenomic changes within the previously unexamined “dark genome” regions of human brains affected by Alzheimer’s disease.

Nov 16, 2025
Gemini
 

Longevity Code: Lipidome Associations And Mediated Metabolite Effects

Specific types of fats (lipids) and small molecules (metabolites) in the body have been found to causally influence an individual’s genetic predisposition to longevity.

Nov 16, 2025
Gemini
 

Redox Homeostasis In Ferroptosis And Aging: A Causal Role For Fard-1 And Dhs-25 In Caenorhabditis Elegans

The study reveals a causal link between ferroptosis, a specific type of iron-dependent cell death, and the process of physiological aging, demonstrating that this connection is mediated by an imbalance in the body’s natural antioxidant systems in the model organism Caenorhabditis elegans.

Nov 16, 2025
Gemini
 

Sphingolipid And Methionine Metabolism In Aging

This review explores the intricate relationship between sphingolipid metabolism, organelle function, and methionine restriction in the context of aging.

Nov 16, 2025
Gemini
 

A Computational Investigation Of Small Peptide Of Methyl Jasmonate And Human Complement Factor In Ageing

Analytical
Therapeutic

A computational study revealed that a small peptide derived from wine grapes interacts with a human protein, Complement Factor H, suggesting a potential role in anti-aging mechanisms.

Nov 13, 2025
Gemini
 

A Novel Polypeptide Inhibitor Of MMP-1 Attenuates The UVA-Mediated Skin Aging

Therapeutic
Aging Pathway

A newly developed polypeptide inhibitor effectively reduces UVA-induced skin aging by targeting a key enzyme, improving skin firmness and reducing wrinkles.

Nov 13, 2025
Gemini
 

Age Differences In Spontaneous Cerebrovascular Reactivity At Rest

Aging Pathway

Older adults, even those without cognitive impairment, exhibit reduced spontaneous cerebrovascular reactivity at rest compared to younger adults, especially in brain regions like the medial temporal lobe.

Nov 13, 2025
Gemini
 

An Fmri Approach To Assess Intracranial Arterial-To-Venous Cardiac Pulse Delay In Aging

Analytical

A new method using functional MRI can measure the delay between arterial and venous pulsations in the brain, revealing that this delay shortens with age and is faster in men compared to women.

Nov 13, 2025
Gemini
 

Association Between Biological Aging And Genetic Susceptibility With The Risk Of Bipolar Disorder And Schizophrenia: A Prospective Cohort Study

Analytical

Accelerated biological aging is significantly associated with an increased risk of developing bipolar disorder and schizophrenia, with an even higher risk observed when combined with a strong genetic predisposition.

Nov 13, 2025
Gemini
 

Association Between Home Environment Characteristics, Indoor Dust Microbiota And Frailty Among Community-Dwelling Older Adult Couples

Lever

Certain home environment factors, including specific temperature ranges and the makeup of indoor dust microbes, are linked to frailty in older adult couples.

Nov 13, 2025
Gemini
 

Association Of Biological Age Acceleration With Mortality In Adults With Diabetes Or Prediabetes: A Mediating Role Of Physical Activity

Clock
Lever

Adults with diabetes or prediabetes who experience accelerated biological aging face a higher risk of mortality, a risk that is partially mitigated by engaging in higher levels of physical activity.

Nov 13, 2025
Gemini
 

Bridging Social Isolation, Loneliness, And Brain Aging: A Narrative Review Of Mechanisms And Translational Interventions

Aging Pathway
Lever

Social isolation and loneliness are significant factors contributing to accelerated brain aging and cognitive decline, operating through a self-reinforcing cycle involving interconnected brain networks and molecular mechanisms.

Nov 13, 2025
Gemini
 

Clonal Hematopoiesis Of Indeterminate Potential: A Review Of Its Cardiorenal Implications And Aging

Aging Pathway

Clonal hematopoiesis of indeterminate potential (CHIP), an age-related condition characterized by acquired mutations in blood stem cells, is linked to an increased risk of developing cardiovascular and kidney diseases.

Nov 13, 2025
Gemini
 

Combination Antiretroviral Therapy Prevents SIV-Induced Aging In The Hippocampus And Neurodegeneration Throughout The Brain

Therapeutic
Aging Pathway

Combination antiretroviral therapy effectively reverses accelerated brain aging and reduces nerve cell damage caused by simian immunodeficiency virus infection.

Nov 13, 2025
Gemini
 

Decoding Noncoding Rnas In Regulating Cardiovascular Aging And Age-Related Conditions: The Emerging Landscape

Aging Pathway

Non-coding RNAs, including microRNAs, long non-coding RNAs, and circular RNAs, play a crucial role in regulating cardiovascular aging and associated diseases by influencing both pro-aging and anti-aging processes.

Nov 13, 2025
Gemini
 

Defective Chaperone-Mediated Autophagy In The Retinal Pigment Epithelium Of Age-Related Macular Degeneration Patients

Aging Pathway
Therapeutic

A specific cellular cleaning process called chaperone-mediated autophagy is found to be defective in the retinal pigment epithelium of patients with age-related macular degeneration, contributing to the disease.

Nov 13, 2025
Gemini
 

Diagnostic Accuracy Of Sarcopenia Screening Tools In Low-Income Older Adults In Amazonas, Brazil

Analytical

The Ishii test demonstrated the highest diagnostic accuracy for sarcopenia in low-income older adults in the Amazonas region of Brazil.

Nov 13, 2025
Gemini
 

Dissociation Of The Nuclear Basket Triggers Chromosome Loss In Aging Yeast

Aging Pathway

Aging in yeast causes the nuclear basket to detach from the nuclear pore complex, leading to the asymmetric distribution and loss of chromosomes, a process linked to the leakage of unprocessed genetic material.

Nov 13, 2025
Gemini
 

Effects Of Protein-Based Multinutrient Therapy On Sarcopenia In Older Adults: A Systematic Review And Meta-Analysis

Therapeutic
Lever
Analytical

Protein-based multinutrient therapy significantly improved handgrip strength, gait speed, and Insulin-like Growth Factor-1 levels in older adults with sarcopenia.

Nov 13, 2025
Gemini
 

Estrogen Depletion And Immune Activation And Inflammation In Women With HIV

Aging Pathway

Estrogen depletion during menopause in women with HIV alters immune responses, leading to chronic inflammation, increased risk of other health conditions, and the persistence of the HIV reservoir.

Nov 13, 2025
Gemini
 

Evaluation And Research Progress On Rodent Models Of Late-Onset Hypogonadism: A Comprehensive Review

Aging Pathway

A comprehensive review summarizes and analyzes the characteristics, methods, and evaluation systems of various rodent models used in late-onset hypogonadism research to guide optimal model selection and development.

Nov 13, 2025
Gemini
 

Evaluation And Research Progress On Rodent Models Of Late-Onset Hypogonadism: A Comprehensive Review

Aging Pathway

This comprehensive review synthesizes the characteristics, methodologies, and assessment criteria of various rodent models employed in the study of late-onset hypogonadism, critically evaluating their strengths and weaknesses to inform optimal model selection for future research.

Nov 13, 2025
Gemini
 

Exercise Attenuates Inflammaging And Testosterone Decline In Aged And Morphine-Treated Rats: A Role For NF-Κb Signaling

Aging Pathway
Lever

Regular exercise can reduce age-related inflammation and testosterone decline, even in the presence of morphine, by influencing a specific cellular signaling pathway.

Nov 13, 2025
Gemini
 

Exercise Intensity Influences Body Composition: A 6-Month Comparison Of High-Intensity Interval, Moderate- And Low-Intensity Training Among Healthy Older Adults

Lever

A 6-month study found that high-intensity exercise effectively reduced body fat and preserved muscle mass in healthy older adults, while moderate-intensity exercise also reduced fat but led to some loss of muscle.

Nov 13, 2025
Gemini
 

Exploring A Crossroads In The Aging Process

Aging Pathway

Experiments on yeast reveal that the nuclear pore complex plays a central role in the age-related loss of chromosomes.

Nov 13, 2025
Gemini
 

Exploring Senescence Markers As Potential Drivers Of Osteoarthritis Pain In Aging Adults

Aging Pathway

The paper suggests that senescent cells and the inflammatory molecules they release play a significant role in driving osteoarthritis pain in older adults.

Nov 13, 2025
Gemini
 

Exploring The Effects Of A Multicomponent Phytoceutical Health Product In A Drosophila Melanogaster Ageing And Repetitive Concussion Model

Therapeutic

A natural health product, CONKA1, was found to improve lifespan, motor activity, and reduce cellular damage from oxidative stress in fruit flies, even when subjected to repetitive concussions.

Nov 13, 2025
Gemini
 

Factors Associated With Frailty Transitions Using The Kihon Checklist: A 6-Year Longitudinal Study Among Japanese Residents

Analytical
Lever

A long-term study revealed specific social, physical, and cognitive factors that determine whether older Japanese adults remain healthy, become more vulnerable, or recover from frailty.

Nov 13, 2025
Gemini
 

Factors Associated With Risk Of Clonal Haematopoiesis Of Indeterminate Potential: A Systematic Review And Meta-Analysis

Analytical

A systematic review and meta-analysis found that hypertension, HIV infection, and smoking are linked to an increased risk of Clonal Haematopoiesis of Indeterminate Potential (CHIP), while Asian ethnicity is associated with a lower risk, with these associations varying by specific gene mutations.

Nov 13, 2025
Gemini
 

Frailty Modulates The Predictive Value Of Performance Status In Older Adults Living With Cancer

Analytical

Frailty significantly alters how well a patient’s performance status predicts their outcome in older adults living with cancer, making traditional performance status tools less reliable for frail individuals.

Nov 13, 2025
Gemini
 

GLP-1R Agonists And Muscle Health: Potential Role In Sarcopenia Prevention And Treatment

Therapeutic
Aging Pathway

GLP-1 receptor agonists, commonly used for weight loss and diabetes, have shown promising muscle-preserving effects in preclinical studies, but clinical trials indicate a concern regarding the loss of lean muscle mass alongside fat loss, particularly in vulnerable populations.

Nov 13, 2025
Gemini
 

Identification And Molecular Mechanisms Of Novel Antioxidant Peptides From Manila Clam Hydrolysate: Caenorhabditis Elegans Model, Molecular Simulations, And Quantum Chemistry

Therapeutic
Aging Pathway

Researchers have identified novel antioxidant peptides from Manila clam hydrolysates that exhibit significant antioxidant activity, prolong the lifespan of Caenorhabditis elegans, and protect human cells from oxidative stress.

Nov 13, 2025
Gemini
 

Integrative Omics Reveal Female-Specific Benefits Of P16+ Cell Clearance In Aging Mice

Aging Pathway
Therapeutic

Clearing specific aging cells, known as p16+ cells, primarily benefits female mice by improving their physical health, regenerating skin, and reducing liver damage.

Nov 13, 2025
Gemini
 

Lights For Aging: Can Photobiomodulation Restore Functionality In The Cerebral Networks Of Aged Individuals?

Therapeutic

The paper suggests that using red and near-infrared light, known as photobiomodulation, may help to slow brain aging, reduce inflammation, and improve overall brain function and quality of life in older adults.

Nov 13, 2025
Gemini
 

N-Acetylcarnosine Attenuates Age-Associated Declines In Multi-Organ Systems To Improve Survival

Therapeutic

A six-month treatment with N-acetylcarnosine significantly reduced various age-related health issues and extended the lifespan of female mice by approximately 50%.

Nov 13, 2025
Gemini
 

Neuronal Pentraxin 1 Accelerates Post-Stroke Atherosclerosis By Inducing Endothelial Cell Senescence

Aging Pathway
Therapeutic

A protein called neuronal pentraxin 1 (NPTX1) increases after a stroke and speeds up the development of atherosclerosis, a condition where arteries harden, by causing the cells lining blood vessels to age prematurely.

Nov 13, 2025
Gemini
 

Polyamine Treatment In Elderly Patients With Coronary Artery Disease (POLYCAD): Study Protocol For A Danish Randomised, Double-Blind, Placebo-Controlled Trial Of Spermidine Treatment Versus Placebo

Therapeutic

A Danish randomized, double-blind, placebo-controlled trial is investigating whether daily spermidine treatment can improve heart health, physical fitness, muscle mass, and reduce inflammation in elderly patients with Coronary Artery Disease.

Nov 13, 2025
Gemini
 

Ppp1R3G Inhibition Impairs Opcs Differentiation And Myelination In Aged Mice

Aging Pathway
Therapeutic

A protein called PPP1R3G is crucial for maintaining the brain’s white matter and cognitive function in aging, and its decline contributes to age-related cognitive impairment.

Nov 13, 2025
Gemini
 

Preventive Effect Of Fisetin On Follicular Granulosa Cells Senescence Via Attenuating Oxidative Stress And Upregulating The Wnt/Β-Catenin Signaling Pathway

Therapeutic
Aging Pathway

Fisetin, a natural compound, has been found to prevent the aging of ovarian cells by reducing cellular damage and improving cell growth processes, potentially safeguarding egg production.

Nov 13, 2025
Gemini
 

Preventive Effect Of Fisetin On Follicular Granulosa Cells Senescence Via Attenuating Oxidative Stress And Upregulating The Wnt/Β-Catenin Signaling Pathway

Therapeutic
Aging Pathway

Fisetin, a natural compound, has been found to prevent the aging of ovarian cells by reducing cellular stress and improving cell function, potentially benefiting egg production in aging animals.

Nov 13, 2025
Gemini
 

Revisiting The Relationship Between Cardiorespiratory Fitness And Biological Aging: Insights From Dunedinpace Analysis

Clock
Lever

Higher cardiorespiratory fitness is associated with a slower pace of biological aging, and a specific fitness threshold was identified that differentiates individuals with slower biological aging.

Nov 13, 2025
Gemini
 

Sex And APOE Ε2 Interactive Effects On The Longitudinal Change In Cognition In A Population-Based Cohort Of Older Adults With Vascular Risk Factors

Aging Pathway
Analytical

The APOE ε2 genetic variant may negatively impact verbal memory in aging men and does not consistently protect against cognitive decline over time.

Nov 13, 2025
Gemini
 

Sex And APOE Ε2 Interactive Effects On The Longitudinal Change In Cognition In A Population-Based Cohort Of Older Adults With Vascular Risk Factors

Aging Pathway

A study on older adults with vascular risk factors found that the APOE ε2 gene, often considered protective, may surprisingly be linked to a decline in verbal memory in aging males, while not providing a consistent protective effect for females.

Nov 13, 2025
Gemini
 

Sex Differences In The Associations Among Grip Strength, Walking Speed, Sarcopenic Obesity, And Mild Cognitive Impairment: Evidence From The Qingdao (Laoshan) Aging And Cognition Screening (QLACS) Project

Analytical

The study revealed that the relationships between physical indicators like grip strength, walking speed, and sarcopenic obesity, and the risk of mild cognitive impairment, differ significantly between men and women.

Nov 13, 2025
Gemini
 

Sirt1/PGC-1Α/Mfn2 Pathway Regulates Mitochondrial Homeostasis In VSMC To Attenuate Aging-Related Vascular Calcification

Aging Pathway

This research reveals that a specific cellular pathway involving SIRT1, PGC-1α, and Mfn2 is essential for maintaining healthy mitochondria in blood vessel cells, and enhancing this pathway can reduce the hardening of arteries associated with aging.

Nov 13, 2025
Gemini
 

The Association Between CKD And Frailty In The FRASNET Study: Suggestion Of A Novel Egfr Threshold As A Key Determinant Of Frailty In The Elderly

Analytical

The study identified a new estimated glomerular filtration rate (eGFR) threshold of 53.5 ml/min/1.73 m2 that is significantly associated with frailty in older adults, suggesting a critical level of kidney function for maintaining physical resilience.

Nov 13, 2025
Gemini
 

The Association Between Divorce And Late-Life Brain Health In A Racially And Ethnically Diverse Cohort Of Older Adults

Lever

A study on a diverse group of older adults indicated that a history of divorce was not significantly linked to late-life brain health outcomes, including brain volume and white matter changes.

Nov 13, 2025
Gemini
 

The Influence Of Structured Physical Activity On Vaccination Response From Adults To Older Individuals: A Systematic Review On The Immunoinflammatory Crosstalk Of COVID-19

Lever

Regular structured physical activity can improve the body’s immune response to COVID-19 vaccination and reduce inflammation in adults and older individuals.

Nov 13, 2025
Gemini
 

The Interplay Between Genotoxic Stress And STING Activation In Cellular Senescence And Inflammatory Responses

Aging Pathway

The paper reveals that DNA damage, or genotoxic stress, activates a cellular pathway called STING, which then drives cellular aging and inflammatory responses.

Nov 13, 2025
Gemini
 

The Mediating Role Of Biological Age In The Impact Of Mood Instability Symptoms On Neurodegenerative Disease And Mortality

Clock
Analytical

Severe mood instability symptoms are linked to an increased risk of neurodegenerative diseases and mortality, with accelerated biological aging playing a partial role in this connection.

Nov 13, 2025
Gemini
 

The Role Of The Sirt1 And Mtor Pathways In Exercise-Induced Β-Cell Senescence Reduction In Type 2 Diabetes Mellitus

Aging Pathway
Lever
Therapeutic

Exercise helps reduce the aging and dysfunction of insulin-producing cells in individuals with type 2 diabetes by activating the SIRT1 pathway and inhibiting the mTOR pathway.

Nov 13, 2025
Gemini
 

Accelerated Regeneration Of Senescent Bone Injury Through Age- And Sex-Independent Macrophage Polarization

Therapeutic
Aging Pathway

A new therapeutic strategy using phosphatidylserine liposomes has been shown to accelerate bone regeneration in senescent bone injuries by promoting a pro-healing macrophage response, regardless of the age or sex of the individual.

Nov 12, 2025
Gemini
 

Allicin Attenuates Age-Related Cognitive And Neural Decline In A Rat Model By Modulating Amyloid Burden And Regulating BDNF/Nrf2 Gene Expression

Therapeutic
Aging Pathway

Allicin, a compound found in garlic, has been shown to reduce age-related cognitive and neural decline in a rat model by decreasing amyloid protein accumulation and regulating gene expression related to brain health.

Nov 12, 2025
Gemini
 

Association Between Blood Nicotinamide Adenine Dinucleotide Levels And Blood Laboratory Parameters At Baseline And After Nicotinamide Mononucleotide Supplementation In Middle-Aged Healthy Individuals: Post Hoc Analysis Of A Randomized, Double-Blinded, Placebo-Controlled Clinical Trial

Therapeutic

Supplementation with nicotinamide mononucleotide (NMN) was found to increase blood nicotinamide adenine dinucleotide (NAD) levels, which in turn was associated with improvements in red blood cell parameters in middle-aged healthy individuals.

Nov 12, 2025
Gemini
 

Autophagy-Senescence Interplay In Kidney Disease: Mechanistic Insights And Therapeutic Potential

Aging Pathway
Therapeutic

The intricate relationship between cellular self-cleaning processes and cellular aging plays a significant role in the development and progression of kidney diseases, offering new avenues for therapeutic interventions.

Nov 12, 2025
Gemini
 

Cardiovascular And Peripheral Factors Affecting The Decay Of Maximal Oxygen Uptake Across The Spectrum Of Age In Humans

Analytical

The progressive increase in the resistance of peripheral tissues to oxygen uptake significantly contributes to the age-related decline in maximal oxygen uptake, potentially more than the decrease in the heart’s ability to transport oxygen.

Nov 12, 2025
Gemini
 

Chaperone-Mediated Autophagy Controls Brown Adipose Tissue Thermogenic Activity

Aging Pathway
Therapeutic

A cellular recycling process called chaperone-mediated autophagy is essential for brown fat to generate heat, particularly as the body ages, by breaking down proteins that suppress this heat-producing activity.

Nov 12, 2025
Gemini
 

Correction: Machine Learning Approach For Frailty Detection In Long-Term Care Using Accelerometer-Measured Gait And Daily Physical Activity: Model Development And Validation Study

Analytical

Machine learning models can identify frailty in older adults in long-term care settings by analyzing their walking patterns and daily physical activity, with a correction clarifying that frail individuals exhibit lower gait symmetry scores, indicating more asymmetrical walking.

Nov 12, 2025
Gemini
 

Dietary Iron Attenuates Epigenetic Aging Through DNA Methylation Remodeling And Extends Survival In Older Adults

Clock
Lever

Higher dietary iron intake is associated with favorable epigenetic profiles related to aging and a reduced risk of death from various causes in older adults.

Nov 12, 2025
Gemini
 

Distinct Senotypes In P16- And P21-Positive Cells Across Human And Mouse Aging Tissues

Aging Pathway
Analytical

Cells marked by p16 and p21, both indicators of cellular aging, represent largely distinct populations with different characteristics and contributions to aging across various human and mouse tissues.

Nov 12, 2025
Gemini
 

Elevated Alpha-1 Antitrypsin And C-Reactive Protein: Association On All-Cause And Cause-Specific Mortality In Older Adults

Analytical

Elevated levels of alpha-1 antitrypsin, an inflammation-regulating protein, are a strong independent predictor of overall mortality in older adults, with an even greater risk when combined with high levels of C-reactive protein, another inflammation marker.

Nov 12, 2025
Gemini
 

Epigenetic Dysregulation In Aged Muscle Stem Cells Drives Mesenchymal Progenitor Expansion Via IL-6 And Spp1 Signaling

Aging Pathway
Therapeutic

Aged muscle stem cells independently drive the expansion of fibro-adipogenic progenitors and promote muscle scarring through specific epigenetic changes and signaling pathways.

Nov 12, 2025
Gemini
 

Immune-Mediated Interactions Between Sarcopenia And Atherosclerosis In Aging

Aging Pathway
Therapeutic

Sarcopenia, an age-related loss of muscle mass, and atherosclerosis, the hardening of arteries, are interconnected by shared immune system pathways, particularly chronic inflammation associated with aging.

Nov 12, 2025
Gemini
 

Impact Of Histone Post-Translational Modification Inhibitors On Lifespan, Reproduction, And Stress Response In The Rotifer Brachionus Manjavacas

Aging Pathway
Therapeutic

Inhibiting specific histone modifications in the rotifer Brachionus manjavacas can extend lifespan and improve stress resistance without negatively affecting reproduction.

Nov 12, 2025
Gemini
 

Intracellular And Extracellular Redox Signals During Exercise And Aging

Aging Pathway
Lever

The paper reveals that reactive oxygen species act as critical signals within and between cells, influencing how muscles adapt to exercise and aging, thereby impacting muscle function and metabolic health.

Nov 12, 2025
Gemini
 

Ketotifen Reacidifies Secretory Lysosomes And Normalises Ageing Phenotypes In Mast Cells

Aging Pathway
Therapeutic

A recent study discovered that a common medication called ketotifen can restore the proper acidic environment within specialized compartments of immune cells called mast cells, thereby reversing certain age-related changes in these cells.

Nov 12, 2025
Gemini
 

KLOTHO-VS Heterozygosity, Α-KLOTHO Protein Levels And Cognitive Performance In Alzheimer’S Disease

Aging Pathway

Individuals with the KLOTHO-VS gene variant heterozygosity showed better memory performance, especially in those with early memory impairment and a specific genetic risk factor for Alzheimer’s disease.

Nov 12, 2025
Gemini
 

Longevity-Promoting Mitochondrial Unfolded Protein Response Activation Requires Elements Of The Pebow Complex

Aging Pathway

Reduced function of the VDAC-1 protein extends lifespan by activating a cellular stress response in mitochondria, a process that requires components of the PeBoW complex.

Nov 12, 2025
Gemini
 

Luteoloside Alleviates Bleomycin-Induced Pulmonary Fibrosis In Mice Via Sirt1-Mediated Protective Effect Against Alveolar Epithelial Cell Senescence

Therapeutic
Aging Pathway

Luteoloside, a compound found in plants, was shown to reduce lung scarring, oxidative stress, and cell aging in mice with bleomycin-induced pulmonary fibrosis, with its protective effects being mediated by a protein called SIRT1.

Nov 12, 2025
Gemini
 

Mechanopharmacology Of Cellular Microenvironment Stiffness: Therapeutic Strategies For Age-Related Diseases

Aging Pathway
Therapeutic

The paper highlights how increased stiffness in the cellular environment, a common change with aging, contributes to age-related diseases and explores strategies to target these mechanical changes for therapeutic benefit.

Nov 12, 2025
Gemini
 

Mesenchymal Stem Cell Derived Extracellular Vesicles Reverses Neural Aging Via OSKM Modulation

Therapeutic
Aging Pathway

MicroRNAs within extracellular vesicles derived from mesenchymal stem cells have been shown to reactivate aging cells by increasing specific transcription factors, suggesting a reversal of neural aging.

Nov 12, 2025
Gemini
 

Methodological Considerations Of Diet Assessment Of The Older Indian Population In The Longitudinal Aging Study In India-Harmonised Diagnostic Assessment Of Dementia (LASI-DAD)

Lever

The study successfully developed and implemented a comprehensive food frequency questionnaire for assessing the dietary intake of older Indian adults across diverse regions.

Nov 12, 2025
Gemini
 

Multi-Omic Profiling Reveals Age-Related Immune Dynamics In Healthy Adults

Aging Pathway
Analytical

A comprehensive study of healthy adults reveals that aging leads to specific changes in T cell gene activity, resulting in a T helper 2 cell bias that impairs B cell responses to vaccines.

Nov 12, 2025
Gemini
 

NMN Supplementation As A Strategy To Improve Oocyte Quality: A Systematic Review And Transcriptomic Analysis

Therapeutic
Aging Pathway
Analytical

NMN supplementation has been shown to improve egg cell quality by addressing mitochondrial dysfunction and NAD+ depletion, which are often associated with aging and metabolic stress.

Nov 12, 2025
Gemini
 

Premature Aging And Neuropathic Behaviours Induced By An Acute Low-Dose Exposure To A Sarin Surrogate

Aging Pathway

A single exposure to a low dose of a sarin-like chemical can lead to signs of premature aging and long-lasting nerve-related problems in mice.

Nov 12, 2025
Gemini
 

Protective And Reparative Effects Of Tremella Aurantialba Extract Against Skin Photoaging And Its Underlying Mechanisms

Therapeutic
Aging Pathway

An extract from the mushroom Tremella aurantialba demonstrates protective and reparative effects against skin aging caused by sun exposure by reducing oxidative stress, inflammation, and restoring skin barrier function and microbiota balance.

Nov 12, 2025
Gemini
 

Social Isolation And Cardiometabolic Burden Synergistically Predict Physical Dysfunction In Aging Chinese Adults: Evidence Of Risk Thresholds And The Mediating Role Of Frailty

Analytical

Social isolation and multiple cardiometabolic health problems together significantly increase the risk of physical decline in aging Chinese adults, with frailty acting as a key intermediate factor.

Nov 12, 2025
Gemini
 

A NADH Oxidase Nanozyme Restores Redox Homeostasis To Ameliorate Multi-Organ Aging And Ischemic Cardiomyopathy

Therapeutic
Aging Pathway

A vanadium-based nanozyme has been shown to restore the balance of critical molecules involved in cellular energy (redox homeostasis), thereby reducing signs of aging in multiple organs and improving heart function after a heart attack.

Nov 11, 2025
Gemini
 

Association Of Sarcopenia And Pancreatic Exocrine Insufficiency In Older Adults Type 2 Diabetes Mellitus Patients

Analytical

Pancreatic exocrine insufficiency may contribute to sarcopenia in older adult males with type 2 diabetes mellitus.

Nov 11, 2025
Gemini
 

Brain-Age Models With Lower Age Prediction Accuracy Have Higher Sensitivity For Disease Detection

Clock
Analytical

Brain-age models with lower accuracy in predicting chronological age demonstrate a higher ability to detect disease-related changes in the brain.

Nov 11, 2025
Gemini
 

Characteristics Of Peripheral Blood Lymphocyte Subsets In Elderly Patients With Psoriasis

Analytical

Elderly individuals with psoriasis exhibit specific changes in their immune cell populations, including a decrease in certain T cells and an increase in natural killer cells, with B cells showing potential as markers for disease severity.

Nov 11, 2025
Gemini
 

Comparative Evaluation Of Extraction Methods For Scorias Spongiosa Polysaccharides: Yield, Bioactivity, And Anti-Aging Potential

Therapeutic

The study compared different methods for extracting beneficial complex sugars from Scorias spongiosa, demonstrating that the chosen extraction technique significantly impacts the amount obtained, their biological effectiveness, and their capacity to offer anti-aging benefits.

Nov 11, 2025
Gemini
 

Deciphering The Emerging Interrelationship Between Cellular Senescence And Extracellular Vesicles: Implications For Therapy And Diagnosis

Aging Pathway
Therapeutic

Cellular senescence, a process linked to aging and disease, interacts with tiny sacs released by cells called extracellular vesicles, which can either promote or suppress this senescence and may offer new avenues for diagnosis and treatment.

Nov 11, 2025
Gemini
 

Differential Cognitive Enhancer Effects Of Acetylcholinesterase Inhibitors And Memantine On Age-Related Deficits In Vigilance And Sustained Attention: A Preclinical Validation Study

Therapeutic

This preclinical study demonstrated that different Alzheimer’s disease medications have distinct effects on age-related attention and vigilance deficits in rats, with some improving reaction time and others improving accuracy.

Nov 11, 2025
Gemini
 

Ejiao Alleviates Sarcopenia By AKT/Mtor/Foxo3A And AMPK Pathways In An Aging Rat Model Induced By D-Galactose Combined With Restricted Movement

Therapeutic
Aging Pathway

Ejiao significantly improves muscle function and provides a promising avenue for sarcopenia treatment by reducing oxidative stress, enhancing ATP levels, and modulating key pathways involved in protein synthesis and muscle function.

Nov 11, 2025
Gemini
 

ERC Accumulation Depletes Sir2 From Rdna And Induces Cellular Senescence By Rdna Destabilization

Aging Pathway

The accumulation of extrachromosomal ribosomal DNA circles in aging cells leads to the depletion of the Sir2 protein from the main ribosomal DNA, causing ribosomal DNA destabilization and promoting cellular senescence.

Nov 11, 2025
Gemini
 

Extracurricular Physical Activity And Telomere Length In Childhood: Findings From The INMA Study

Lever

Children who engaged in higher levels of extracurricular physical activity at age four showed an increase in their telomere length ranking by age eight, indicating a potential for reduced cellular damage and support for healthy aging.

Nov 11, 2025
Gemini
 

Foxo3A Upregulates DNA Repair Activities By Transcriptional Activation Of Target Genes And Provides The Resistance To Gamma Radiation And The Extension Of Lifespan In Mouse

Aging Pathway

Overexpression of the FOXO3a gene enhances DNA repair mechanisms, leading to increased resistance to radiation and an extension of lifespan in mice.

Nov 11, 2025
Gemini
 

From Structure To Immunity: How Skin Shapes Age-Related Vulnerability To Chikungunya Virus Infections

Aging Pathway

This review explores how age-related changes in the skin’s structure, immune system, and microbial community influence vulnerability to Chikungunya virus infections, especially in infants and the elderly.

Nov 11, 2025
Gemini
 

Geriatric Syndromes In Intestinal Failure: An Accelerated Aging Phenomenon In Middle Adulthood Patients?

Clock

Middle-aged patients with chronic intestinal failure exhibit a high prevalence of geriatric syndromes and premature metabolic aging, indicating that the condition may represent an accelerated aging phenomenon.

Nov 11, 2025
Gemini
 

Glycation-Lowering Compounds Inhibit Ghrelin Signaling To Reduce Food Intake, Lower Insulin Resistance, And Extend Lifespan

Therapeutic
Aging Pathway

A combination of specific compounds has been shown to reduce food intake, improve insulin sensitivity, and extend lifespan by inhibiting hunger signals and lowering harmful sugar-derived byproducts.

Nov 11, 2025
Gemini
 

Gut Metagenome And Plasma Metabolome Profiles In Older Adults Suggest Pyruvate Metabolism As A Link Between Sleep Quality And Frailty

Analytical
Aging Pathway

Research indicates that a metabolic pathway involving pyruvate, influenced by the gut microbiome, may link poor sleep quality to increased physical vulnerability in older adults.

Nov 11, 2025
Gemini
 

Identifying A Proteomics Signature Of Cognitive Impairment And Dementia In Blood And Cerebrospinal Fluid Through A Mediation Analysis Framework

Analytical

A study identified a protein called glial fibrillary acidic protein (GFAP) in both blood and cerebrospinal fluid as a strong indicator that links aging to a higher risk of cognitive decline.

Nov 11, 2025
Gemini
 

Impact Of Meditation On Brain Age Derived From Multimodal Neuroimaging In Experts And Older Adults From A Randomized Trial

Clock
Lever
Analytical

Long-term meditation practice is associated with an appearance of a younger brain compared to one’s actual chronological age.

Nov 11, 2025
Gemini
 

Interaction Between Smoking And Olfactory Function On Frailty: A Population-Based Cross-Sectional Study

Analytical
Lever

A study found that smoking and a reduced sense of smell are independently linked to an increased risk of frailty, and when combined, these factors synergistically elevate the risk of frailty even further.

Nov 11, 2025
Gemini
 

Ketone Catabolism Is Essential For Maintaining Normal Heart Function During Aging

Aging Pathway
Therapeutic
Lever

The body’s ability to break down ketones, a type of fat, is crucial for maintaining healthy heart function as individuals age.

Nov 11, 2025
Gemini
 

Lactobacillus Salivarius-Derived Indole-3-Acetic Acid Promotes AHR-Parp1 Axis-Mediated DNA Repair To Mitigate Intestinal Aging

Aging Pathway
Therapeutic

Researchers found that a molecule produced by the beneficial gut bacterium Lactobacillus salivarius can activate a specific pathway to repair DNA, which helps to slow down the aging of the intestine.

Nov 11, 2025
Gemini
 

Linker Histone Regulates The Myeloid Versus Lymphoid Bifurcation Of Multipotent Hematopoietic Stem And Progenitors

Aging Pathway
Therapeutic

Linker histones play a crucial role in directing multipotent hematopoietic stem and progenitor cells towards either myeloid or lymphoid cell types by influencing how DNA is packaged and accessed.

Nov 11, 2025
Gemini
 

Piezo1 Activation Suppresses Bone Marrow Adipogenesis To Prevent Osteoporosis By Inhibiting A Mechanoinflammatory Autocrine Loop

Aging Pathway
Therapeutic

Activation of the Piezo1 protein in bone marrow stem cells reduces fat accumulation in the bone marrow and promotes bone formation, thereby preventing osteoporosis by disrupting a self-reinforcing inflammatory process.

Nov 11, 2025
Gemini
 

Prostaglandin D2 Axis Impairs Immunity Against Melanoma Via Dendritic Cells And Γδ T Cells In Middle-Aged Mice

Aging Pathway
Therapeutic

A specific signaling pathway involving Prostaglandin D2 hinders the immune system’s ability to fight melanoma by affecting dendritic cells and a type of T cell in middle-aged mice.

Nov 11, 2025
Gemini
 

Rewarding Touch Limits Lifespan Through Neural To Intestinal Signaling

Aging Pathway

Perceiving rewarding, food-like touch can shorten the lifespan of organisms on a calorie-restricted diet by activating a signaling pathway from the nervous system to the intestine.

Nov 11, 2025
Gemini
 

Senescent Cells Promote Viral Infection-Associated Inflammation And Tissue Damage Through A Robust NF-Κb Pathway

Aging Pathway
Therapeutic

Senescent cells exacerbate inflammation and tissue damage during viral infections, especially in older individuals, through the robust activation of a cellular pathway known as NF-κB.

Nov 11, 2025
Gemini
 

Synergistic Relationship Between Muscle Thickness And Cellular Health After Resistance Training In Older Women

Lever

A 12-week resistance training program in older women leads to increased muscle thickness, which is linked to improvements in indicators of cellular health.

Nov 11, 2025
Gemini
 

Targeting Α7Nachr Mitigates Vascular Aging And Endothelial Cell Senescence Through Inhibiting Oxidative Stress And Inflammation Via Α7Nachr/Nrf2/HO-1 Signaling Pathway

Aging Pathway
Therapeutic

Targeting the α7 nicotinic acetylcholine receptor (α7nAChR) can reduce the aging of blood vessels and their lining cells by decreasing harmful oxidative stress and inflammation through a specific signaling pathway involving α7nAChR, Nrf2, and HO-1.

Nov 11, 2025
Gemini
 

Telomerase Depletion Accelerates Ageing Of The Zebrafish Brain

Aging Pathway

Depleting telomerase in zebrafish accelerates various hallmarks of brain aging, including increased inflammation, impaired blood-brain barrier function, and heightened anxiety-like behavior.

Nov 11, 2025
Gemini
 

Tgif1-Deficiency Impairs Osteoclast Differentiation Through Pp2A-Mediated Erk1/2 Dephosphorylation And Attenuates Bone Loss In Mice

Aging Pathway

Deficiency of the Tgif1 protein in bone-resorbing cells leads to impaired cell development and function, which in turn reduces age-related bone loss in mice by altering a specific molecular signaling pathway.

Nov 11, 2025
Gemini
 

The Leaves Fall, Yet The Tree Endures

Aging Theory
Aging Pathway

The paper examines how plants age, highlighting that while individual parts like leaves may senesce, the plant as a whole can achieve remarkable longevity through its continuous renewal and dynamic genetic regulatory mechanisms.

Nov 11, 2025
Gemini
 

A Full Life Cycle Biological Clock Based On Routine Clinical Data And Its Impact In Health And Diseases

Clock
Analytical

Researchers have developed an artificial intelligence model that can accurately predict a person’s biological age and future disease risks from birth through old age using standard clinical data.

Nov 10, 2025
Gemini
 

Accelerated Aging Predicts Earlier Onset Of Ischemic Stroke: A Proteomic And Transcriptomic Investigation

Clock
Analytical

A study revealed that individuals with accelerated biological aging experience ischemic strokes significantly earlier, by almost nine years, compared to those whose biological and actual ages align.

Nov 10, 2025
Gemini
 

Associations Between Reproductive Factors And Frailty In Middle-Aged And Older Women: Evidence From The China Health And Retirement Longitudinal Study

Analytical

Reproductive factors such as the number of biological children, age at menarche, history of abortion, and age at menopause are significantly linked to the risk of frailty in middle-aged and older women.

Nov 10, 2025
Gemini
 

Benchmarking Large Language Models For Personalized, Biomarker-Based Health Intervention Recommendations

Analytical

Large language models show limited suitability for providing unsupervised personalized longevity intervention recommendations based on biomarker profiles, despite proprietary models outperforming open-source ones in comprehensiveness.

Nov 10, 2025
Gemini
 

Birth Size Modifies Longitudinal Associations Between Midlife Educational Level And Physical Function At Late-Life For Men And Women

Lever

A study found that for individuals born smaller, having a lower educational level in midlife is linked to poorer physical ability in old age, an association not observed in those born larger.

Nov 10, 2025
Gemini
 

Cellular And Molecular Mechanisms Underlying Cardiovascular Aging

Aging Pathway
Therapeutic

Aging is a major risk factor for cardiovascular diseases, with alterations at the cellular and molecular levels contributing to conditions like heart failure and atherosclerosis.

Nov 10, 2025
Gemini
 

Cellular Senescence Mediates Doxorubicin Chemotherapy-Induced Vascular Endothelial Dysfunction: Translational Evidence Of Prevention With Senolytic Treatment

Aging Pathway
Therapeutic

This research indicates that cellular senescence, a process where cells stop dividing, contributes to blood vessel dysfunction caused by doxorubicin chemotherapy, and that treatments targeting these senescent cells can prevent this damage.

Nov 10, 2025
Gemini
 

Cocoa Flavanols Alleviate Early Diastolic Dysfunction By Decreasing Left Atrial Volume In A Randomized Double Blinded Trial In Healthy Older Individuals

Lever

Cocoa flavanol consumption was found to improve early signs of heart relaxation problems and reduce the size of heart chambers in healthy older adults.

Nov 10, 2025
Gemini
 

Coffee And Tea Intake, Circulating Inflammatory Biomarkers, And Long-Term Risk Of Dementia: Findings From Two Longitudinal Studies

Lever

Higher coffee consumption, specifically two or more cups per day, is associated with a reduced long-term risk of dementia, a relationship partially explained by the beverage’s impact on inflammatory markers in the body, while moderate tea intake may also be linked to a lower dementia risk.

Nov 10, 2025
Gemini
 

Early-Life Endurance Sports Lowers Frailty And Falls In Former Male Athletes

Lever

A study on older men found that former professional endurance athletes exhibited lower rates of frailty and falls in their later years compared to men who were not athletes.

Nov 10, 2025
Gemini
 

Extraction, Characterization, And Anti-Aging Evaluation Of Flavonoids From Citrus Reticulata ‘Zhangshuensis’

Therapeutic

Flavonoids extracted from a specific citrus variety were found to possess potent antioxidant and anti-aging properties, significantly extending the lifespan and stress resistance of nematodes.

Nov 10, 2025
Gemini
 

Gpx4 Ortholog Regulates The O-Glcnac-DDR Pathway To Preserve Intestinal Stem Cell Homeostasis During Aging And Oxidative Stress

Aging Pathway

A protective enzyme, similar to mammalian GPX4, helps maintain the health and function of intestinal stem cells by linking nutrient sensing and DNA repair mechanisms, especially during aging and stress.

Nov 10, 2025
Gemini
 

Hyper-Maturity And Accelerated Aging In The Hippocampus Of Mouse Models Of Neuropsychiatric Disorders With Anxiety-Like Behavior

Analytical

A new study identified “hyper-maturity” and accelerated aging of brain cells in the hippocampus, a brain region crucial for memory and emotion, as a shared abnormality in mouse models of neuropsychiatric disorders exhibiting anxiety-like behavior.

Nov 10, 2025
Gemini
 

Impact Of Aging On Gut-Lung-Adipose Tissue Interactions And Lipid Metabolism During Influenza Infection In Mice

Aging Pathway
Analytical

Aging significantly exacerbates influenza infection in mice, leading to profound alterations in white adipose tissue, gut microbiota composition, and lipid metabolism that contribute to worse disease outcomes.

Nov 10, 2025
Gemini
 

Jianpi Qiangji Granule Ameliorates Aging-Associated Sarcopenia Via AMPK/PGC-1Α Axis In Samp8 Mice

Therapeutic
Aging Pathway

A traditional Chinese medicine formula called Jianpi Qiangji Granule (JQG) has been shown to improve age-related muscle loss and enhance muscle function in aging mice by activating a key molecular pathway.

Nov 10, 2025
Gemini
 

Jianpi Qiangji Granule Ameliorates Aging-Associated Sarcopenia Via AMPK/PGC-1Α Axis In Samp8 Mice

Therapeutic
Aging Pathway

A traditional Chinese medicine, Jianpi Qiangji Granule, has been shown to improve age-related muscle loss and weakness in mice by enhancing muscle mass and function and reducing muscle cell aging.

Nov 10, 2025
Gemini
 

Leukocyte Telomere Length Mediates The Association Between SIRI And CKD: Insights From NHANES 1999-2002

Analytical

A study found that a higher systemic inflammation response index, a measure of the body’s inflammatory state, is linked to an increased risk of chronic kidney disease, and that shorter leukocyte telomere length, a marker of cellular aging, partially accounts for this connection.

Nov 10, 2025
Gemini
 

Long-Term BMI Trajectories And Epigenetic Age Acceleration: The Role Of Genetic Risk For Obesity

Analytical

Long-term obesity is associated with accelerated biological aging, particularly in individuals with a lower or moderate genetic predisposition to obesity, while being consistently overweight does not show this effect.

Nov 10, 2025
Gemini
 

Medicago Sativa L. Saponin-Driven Lactobacillus Intestinalis Restores Intestinal Stemness In Naturally Aged Mice Via The Bile Acid-FXR-Wnt Signaling Axis

Therapeutic
Aging Pathway

A compound derived from alfalfa, Medicago sativa L. saponin, was found to drive the growth of Lactobacillus intestinalis in aged mice, which then produced a bile acid that helped restore the function of intestinal stem cells by activating a specific signaling pathway.

Nov 10, 2025
Gemini
 

Multi-Cohort, Multi-Sequence Harmonisation For Cerebrovascular Brain Age

Clock
Analytical

This research found that applying specific harmonization methods to brain imaging data significantly improves the consistency of blood flow measurements and the accuracy of predicting brain age across different study groups.

Nov 10, 2025
Gemini
 

Multi-Cohort, Multi-Sequence Harmonisation For Cerebrovascular Brain Age

Clock
Analytical

New research demonstrates that adjusting for variations between MRI scanners significantly improves the accuracy of brain age predictions, especially when incorporating measures of brain blood flow to understand cerebrovascular health.

Nov 10, 2025
Gemini
 

Quantitative MRI Of The Hippocampus Reveals Microstructural Trajectories Of Aging And Alzheimer’S Disease Pathology

Analytical

Quantitative MRI can detect microstructural changes in the hippocampus, such as demyelination and iron deposition, that are associated with both healthy aging and early Alzheimer’s disease pathology.

Nov 10, 2025
Gemini
 

Ribosome Dysregulation And Intervention In Age-Related Infertility

Aging Pathway
Therapeutic

A recent study found that age-related infertility in women is associated with increased activity of genes responsible for making ribosomes in egg cells and surrounding support cells, and that a drug called rapamycin can improve embryo quality and pregnancy success in women experiencing infertility.

Nov 10, 2025
Gemini
 

Sex Differences In The Association Between Heavy Metal Exposure And Frailty In The U.S. Adults: A Cross-Sectional Analysis

Analytical

Exposure to heavy metals such as lead and cadmium is linked to an increased risk of frailty in U.S. adults, with women experiencing a more significant impact.

Nov 10, 2025
Gemini
 

TET Exhibits Enzymatic-Independent And-Dependent Functions During Drosophila Flight Muscle Development And Aging

Aging Pathway

TET, a protein known for modifying DNA, plays crucial roles in fruit fly muscle development and aging through both its DNA-modifying enzymatic activity and other independent functions.

Nov 10, 2025
Gemini
 

The Association Between A Pro-Inflammatory Diet And Brain Age In Middle-Aged And Older Adults

Lever
Analytical

A pro-inflammatory diet is associated with an accelerated brain age, particularly in older adults, suggesting that dietary choices can influence the biological aging of the brain.

Nov 10, 2025
Gemini
 

The Chinese Herbal Formular Kang Shuai Lao Pian Enhances Health Status For Skin, Adipose-Derived Stem Cells, Intestinal Microbes And Metabolites In Naturally Senescent Mice

Therapeutic
Aging Pathway

A Chinese herbal formula called Kang Shuai Lao Pian has been found to enhance the health of skin, fat-derived stem cells, gut microbes, and metabolic processes in naturally aging mice.

Nov 10, 2025
Gemini
 

The Effect Of Long-Term Adherence To Physical Activity Recommendations In Midlife On Plasma Proteins Associated With Frailty In The Atherosclerosis Risk In Communities (ARIC) Study

Lever
Analytical

Maintaining recommended levels of physical activity throughout midlife can positively influence blood proteins linked to frailty, especially those involved in the nervous system and inflammation.

Nov 10, 2025
Gemini
 

The Seminal Fluid Protein SFP-1 Regulates Mated Hermaphrodite Aging And Fat Metabolism In C. Elegans

Aging Pathway

A protein found in the seminal fluid of male C. elegans worms, called SFP-1, is transferred to hermaphrodites during mating and causes them to age faster and deplete their fat reserves.

Nov 10, 2025
Gemini
 

Analysis Of Immune Cell Remodeling And Functional Alterations Induced By Aging And Obesity In Mice

Analytical

Aging and obesity collectively alter the immune system, leading to persistent inflammation and reduced effectiveness of key immune cells.

Nov 9, 2025
Gemini
 

Deciphering The Nexus Of Aging And Pan-Cancer: Single-Cell Sequencing Reveals Microenvironmental Remodeling And Cellular Drivers

Aging Pathway
Analytical
Therapeutic

Single-cell sequencing has revealed that aging remodels the tumor microenvironment by accumulating senescent cells and diminishing anti-tumor immunity, thereby fueling cancer development and progression.

Nov 9, 2025
Gemini
 

Efficacy Of Extracellular Vesicles Derived From Mesenchymal Stromal Cells In Regulating Senescence: In Vitro And In Vivo Insights

Therapeutic

Extracellular vesicles derived from mesenchymal stromal cells have been shown to effectively reduce markers of aging, repair age-related damage, diminish oxidative stress, and normalize gene activity in both laboratory cell cultures and animal models.

Nov 9, 2025
Gemini
 

Galangin Alleviates Vascular Aging And Endothelial Cell Senescence By Targeting Smad3 To Initiate Mitophagy

Therapeutic
Aging Pathway

A natural compound called galangin has been found to slow down the aging of blood vessels and the cells lining them by boosting a cellular cleanup process that removes damaged cell components.

Nov 9, 2025
Gemini
 

Irradiation-Induced Brain Senescence Accelerates Cardiac Aging Via Systemic Mechanisms: Insights From Transcriptomic Profiling

Aging Pathway
Analytical

Brain cell aging, induced by irradiation, can accelerate the aging process in the heart through signals sent throughout the body.

Nov 9, 2025
Gemini
 

Network Toxicology And Molecular Simulation Identify Key Genes And Pathways In PFAS-Induced Premature Ovarian Insufficiency

Aging Pathway
Analytical

This research identified specific genes and biological pathways through which per- and polyfluoroalkyl substances (PFAS) contribute to premature ovarian insufficiency by impacting egg development and accelerating ovarian cell aging.

Nov 9, 2025
Gemini
 

Rosmarinic Acid Alleviates Doxorubicin-Induced Cellular Senescence And Cardiotoxicity By Targeting The 14-3-3/Foxo1 Signaling Axis

Therapeutic
Aging Pathway

Rosmarinic acid, a natural compound, has been found to reduce heart damage and cell aging caused by the chemotherapy drug doxorubicin by influencing a specific cellular pathway.

Nov 9, 2025
Gemini
 

Visualization Of OPN-Targeted Self-Assembled Micelles Encapsulated With An Sirt6 Activator And Doped Indocyanine Green For Attenuating Vascular Aging

Therapeutic
Aging Pathway

Researchers developed a visualized, targeted nanodelivery system using micelles to deliver a SIRT6 activator and an imaging agent, effectively attenuating vascular aging in a mouse model.

Nov 9, 2025
Gemini
 

A Glial Circadian Gene Expression Atlas Reveals Cell-Type And Disease-Specific Reprogramming In Response To Amyloid Pathology Or Aging

Aging Pathway
Analytical

The daily rhythms of gene activity in brain support cells are significantly altered by both the natural aging process and the presence of amyloid plaques, a hallmark of Alzheimer’s disease, with these changes being unique to different types of brain support cells.

Nov 6, 2025
Gemini
 

A Nuclear Hormone Receptor Nhr-76 Induces Age-Dependent Chemotaxis Decline In C. Elegans

Aging Pathway
Aging Theory

A nuclear hormone receptor, nhr-76, has been identified as a key regulator in the age-dependent decline of food-searching behavior in C. elegans worms.

Nov 6, 2025
Gemini
 

Age-Associated T Cell Immunity Decreases Circulating Endothelial Progenitor Cells

Aging Pathway
Therapeutic

Aging leads to an increase in certain immune T cells, which in turn reduces the number of circulating endothelial progenitor cells essential for blood vessel maintenance and repair.

Nov 6, 2025
Gemini
 

Association Between Housework Frequency And Cognitive Impairment Among Chinese Older Adults: A Prospective Cohort Study Based On CLHLS

Lever

Older Chinese adults who performed less frequent housework showed a higher risk of developing cognitive impairment.

Nov 6, 2025
Gemini
 

Cognitive Predictors Of Functional Status Transitions Among Older Adults With Seven-Year Follow-Up: A Latent Transition Analysis

Analytical

A seven-year study revealed that a strong sense of orientation is the most consistent cognitive factor protecting older adults from losing their ability to perform daily tasks.

Nov 6, 2025
Gemini
 

Design And Synthesis Of Senescence-Targeted Prodrugs With Senomorphic And Senolytic Properties To Mitigate Chemotherapy-Induced Kidney Injury

Therapeutic

Researchers have designed a new type of drug that can selectively eliminate harmful senescent cells and suppress the damaging secretions of other senescent cells, showing promise in mitigating kidney injury caused by chemotherapy.

Nov 6, 2025
Gemini
 

Electroacupuncture Plus Exercise For Sarcopenia In Older Adults: Protocol For A Randomized, Controlled, Assessor-Blinded Trial

Therapeutic
Lever

This study protocol outlines a randomized controlled trial designed to evaluate whether adding electroacupuncture to a standard exercise program can better improve walking ability and other physical functions in older adults with sarcopenia compared to exercise alone.

Nov 6, 2025
Gemini
 

Enhancing Cognition In Older Adults With Interactive Wall Exergames

Lever

Interactive wall exergames effectively enhance cognitive performance in older adults, with the combination of movement and mental tasks being the key beneficial element.

Nov 6, 2025
Gemini
 

Epigenetic Aging Signatures In People With Hemophilia

Clock

The study found weak evidence that individuals with severe hemophilia experience accelerated biological aging compared to those with mild hemophilia or healthy individuals, though hemophilic arthropathy was linked to an increased rate of biological aging.

Nov 6, 2025
Gemini
 

Evaluation Of Polygenic Risk Scores For A Possible Genetic Basis Of The Inverse Association Between Cancer And Cognitive Decline

Analytical

A study exploring genetic predispositions found a subtle connection between a higher genetic risk for certain cancers and better scores in a type of cognitive ability, hinting at shared biological pathways.

Nov 6, 2025
Gemini
 

Genetic Association Analyses Of Cognitive Performance Across Multi-Ancestry Older Adults: Application Of Tobit Models

Analytical

A new study reveals that using Tobit models, a specific type of statistical analysis, is more effective at identifying genetic factors influencing cognitive abilities in a diverse group of older adults, especially when traditional tests hit a maximum score.

Nov 6, 2025
Gemini
 

Geriatric Syndromes In Women Living With HIV

Lever

Women living with HIV face an increased risk of developing age-related health conditions, known as geriatric syndromes, at an earlier stage than other populations.

Nov 6, 2025
Gemini
 

Harmonized Cognitive Assessment Protocol (HCAP): What Makes An HCAP An HCAP? An Adaptive Architecture For Measuring Cognitive Aging Around The World

Analytical

A new framework has been developed to enable consistent and culturally relevant measurement of cognitive health in older adults across different countries.

Nov 6, 2025
Gemini
 

Induced Pluripotent Stem Cell-Derived Extracellular Vesicles Prevent Neural Stem Cell Senescence To Promote Cognitive Recovery After Traumatic Brain Injury

Therapeutic
Aging Pathway

A recent study demonstrates that tiny sacs released by induced pluripotent stem cells can prevent the aging of brain stem cells and enhance cognitive recovery, including memory and spatial orientation, following a traumatic brain injury.

Nov 6, 2025
Gemini
 

Inhibition Of The Isg15 Prevents Inflammation-Dependent Ovarian Aging

Aging Pathway
Therapeutic

Inhibiting the protein ISG15 can help prevent inflammation-related ovarian aging and improve female fertility.

Nov 6, 2025
Gemini
 

Longer Duration Of Intact Hypothalamic-Pituitary-Gonadal (HPG) Axis Buffers The Adverse Impact Of Late-Life Frailty In Male Dogs

Aging Pathway

A longer duration of an intact hypothalamic-pituitary-gonadal axis reduces the adverse effects of late-life frailty and associated mortality risk in male dogs.

Nov 6, 2025
Gemini
 

Multi-Omics Analysis Of Testis After Long-Term Exposure To Polystyrene Nanoplastics Reveals Premature Testicular Aging And Age-Dependent Damage In Mice

Aging Pathway
Analytical

Long-term exposure to polystyrene nanoplastics leads to premature testicular aging in young mice and more severe testicular damage in older mice.

Nov 6, 2025
Gemini
 

Porcine Placenta Peptides As A Complementary Functional Food For Skin Rejuvenation: A 12-Week Randomized, Double-Blind, Placebo-Controlled Trial

Therapeutic

A 12-week study found that oral supplementation with porcine placenta peptides significantly reduced wrinkles, improved skin hydration and elasticity, and decreased pigmentation in individuals with signs of skin aging.

Nov 6, 2025
Gemini
 

Prepupal Diapause Reduces Adult Lifespan In The Solitary Alfalfa Leafcutter Bee

Aging Pathway

Prepupal diapause in solitary alfalfa leafcutter bees leads to a significantly shorter adult lifespan and is associated with increased oxidative stress and altered hormone levels.

Nov 6, 2025
Gemini
 

Proteomic Polygenic Risk Scores Of Age-Related Plasma Protein Levels Reveal A Role For Metalloproteinase Inhibitor 2 (Timp2) In Cognitive Performance

Analytical
Aging Pathway

Genetically predicted higher levels of the plasma protein Metalloproteinase inhibitor 2 (TIMP2) are associated with better global cognition and memory performance in humans, consistent with its brain-rejuvenating role observed in mice.

Nov 6, 2025
Gemini
 

Requirements Of Health Professionals And Affected Persons For An App-Based Dual-Task Training For Hearing Impaired Older Adults - A Delphi Survey

Lever

A study investigating app-based training for older adults with hearing impairments found differences in preferred training methods and app features between health professionals and the affected individuals themselves.

Nov 6, 2025
Gemini
 

Rewarding Touch Limits Lifespan Through Neural To Intestinal Signaling

Aging Pathway
Lever

Rewarding tactile sensations, such as those mimicking food, can reduce the lifespan-extending benefits of a restricted diet by activating a signaling pathway from the nervous system to the gut.

Nov 6, 2025
Gemini
 

Sex-Specific Factors And Apoeε4 Genotype Alter Functional Connectivity At Middle Age

Aging Pathway

Previous pregnancies and the APOEε4 genetic risk factor for Alzheimer’s disease significantly alter how different brain regions communicate, influencing cognitive function in middle-aged individuals, particularly females.

Nov 6, 2025
Gemini
 

The Ability Of Activity And Cognition In Old Mice To Predict Age Of Death

Clock
Analytical

A study in old mice revealed that while individual measures like voluntary running activity showed some connection to lifespan, a combination of various physical activity and cognitive factors significantly predicted their age of death.

Nov 6, 2025
Gemini
 

The Longitudinal Association Between Dyslipidemia And Cognitive Trajectory

Analytical

An imbalance of fats in the blood is linked to a faster decline in thinking abilities, including memory and language skills, in older adults.

Nov 6, 2025
Gemini
 

The Predictive Power Of Brain-Predicted Age And Leg Strength On Mobility Decline In Aging: Findings From The Baltimore Longitudinal Study Of Aging

Clock
Analytical

The study found that both accelerated brain aging, as measured by brain-predicted age, and weaker leg strength independently predict a decline in mobility among older adults.

Nov 6, 2025
Gemini
 

Vitamin B12 Deficiency Among Older Adults And Its Associations With Geriatric Syndromes

Therapeutic

Vitamin B12 deficiency is prevalent and often undiagnosed in older adults, and it is consistently associated with various age-related health issues known as geriatric syndromes.

Nov 6, 2025
Gemini
 

What Changes First? Mapping The Temporal Ordering Of Age-Related Functional Decline Across Domains Using 30-Year Longitudinal Data

Analytical

Longitudinal research indicates that declines in physical and cognitive abilities generally emerge before changes in social functioning, with no distinct order found for emotional well-being.

Nov 6, 2025
Gemini
 

Wide-Band Electrical-Impedance-Spectroscopy Integrated Microfluidic Organism-On-A-Chip Device For Simultaneous Monitoring Of Multi-Organ Degradation Along C. Elegans Aging

Analytical

A novel microfluidic device integrated with electrical impedance spectroscopy has been developed to simultaneously monitor the degradation of multiple organs in C. elegans as they age.

Nov 6, 2025
Gemini
 

Association Of Estimated Glucose Disposition Rate With Aging Acceleration And Mortality Risk In Individuals With Cardiovascular-Kidney-Metabolic Syndrome: Evidence From Two Large National Population-Based Studies

Analytical

A lower estimated glucose disposition rate is linked to accelerated biological aging and a higher risk of death in individuals diagnosed with cardiovascular-kidney-metabolic syndrome.

Nov 5, 2025
Gemini
 

Bacillus Subtilis TO-A Suppresses The Age-Related Decline In Locomotion In Caenorhabditis Elegans

Therapeutic

A probiotic bacterium, Bacillus subtilis TO-A, has been found to prevent the age-related decrease in movement in the model organism Caenorhabditis elegans by maintaining muscle structure and influencing genes related to oxidative stress.

Nov 5, 2025
Gemini
 

Comprehensive Analysis Of Aberrant Alternative Splicing And RNA Binding Proteins Associated With Age-Related Sensorineural Hearing Loss

Analytical
Aging Pathway

Research has identified numerous altered gene processing events and their regulating proteins linked to age-related sensorineural hearing loss in a mouse model, with ISG15 emerging as a crucial regulator of these processes.

Nov 5, 2025
Gemini
 

Diet, Nutrition, And Healthy Aging: Are Mirnas The Link? A Narrative Review

Aging Pathway

MicroRNAs may serve as a crucial molecular link, explaining how dietary intake can regulate gene expression and consequently impact the aging process and overall lifespan.

Nov 5, 2025
Gemini
 

Emerging Perspectives In Anti-Aging Treatments Using Anti-Fibrotic Strategies

Therapeutic
Aging Pathway

Excessive scar tissue buildup, known as fibrosis, is a key characteristic of aging organ degeneration and a significant factor in organ failure, suggesting anti-fibrotic treatments could offer new strategies for anti-aging.

Nov 5, 2025
Gemini
 

Evidence Of Biological Aging Through Mitochondrial DNA Damage And Dysregulation Of Mitophagy-Related Genes In Veterans With Delayed Sulfur Mustard Toxicity

Aging Pathway

Exposure to sulfur mustard causes long-lasting damage to the powerhouses of cells, called mitochondria, and disrupts their ability to clean up faulty components, leading to accelerated biological aging in affected individuals.

Nov 5, 2025
Gemini
 

Fisetin Topical Delivery Via Ascorbyl Palmitate/Hyaluronan-Enhanced Limosomes: A Novel Paradigm For Preventing UVB-Induced Skin Photoaging

Therapeutic

A new delivery system using limosomes enhanced with ascorbyl palmitate and hyaluronan effectively transports the antioxidant Fisetin into the skin, significantly reducing signs of UVB-induced photoaging and inflammation.

Nov 5, 2025
Gemini
 

Fundc1 Deficiency Aggravates Endothelial Senescence And Retinal Dysfunction

Aging Pathway
Therapeutic

A lack of the protein FUNDC1 worsens the aging of blood vessel lining cells and contributes to the decline in retinal function.

Nov 5, 2025
Gemini
 

Gaining Brain Insights By Tapping Into The Black Box: Linking Structural MRI Features To Age And Cognition Using Shapley-Based Interpretation Methods

Analytical

The study revealed that average signal strengths in brain regions beneath the cortex are consistently linked to brain aging, while specific areas like the hippocampus, cerebellum, and parts of the frontal and temporal lobes are key in predicting fluid intelligence.

Nov 5, 2025
Gemini
 

How Does Life Course Exposure To Contextual Disadvantage Accelerate Biological Aging? The Role Of Psychological Symptoms

Clock

Living in disadvantaged neighborhoods over one’s lifetime accelerates biological aging, partly due to increased psychological distress.

Nov 5, 2025
Gemini
 

Macrophage Metabolic Rewiring Rejuvenates Muscle Raman Signatures And Cellular Remodeling During Regrowth In Aged Mice

Aging Pathway
Therapeutic

Metabolically stimulating macrophages with transient low oxygen conditions improved muscle cellular remodeling and functional recovery in aged mice following disuse atrophy, restoring a youthful recovery pattern.

Nov 5, 2025
Gemini
 

Mettl3-Mediated Modification Of Sirt1 M6A Methylation Protects Osteoblasts From TBHP-Induced Senescence And Promotes Osteoblast Proliferation

Aging Pathway

Research indicates that a specific genetic modification, METTL3-mediated SIRT1 m6A methylation, helps protect bone-forming cells from chemically-induced aging and promotes their multiplication.

Nov 5, 2025
Gemini
 

Microglial Replacement Reverses Age-Associated Epigenetic Modifications Despite Accelerating Epigenetic Age

Clock
Therapeutic

Microglial replacement reverses a substantial portion of age-related chemical modifications to DNA, particularly in immune-related pathways, even though it appears to accelerate the overall epigenetic age.

Nov 5, 2025
Gemini
 

Non-Autonomy Of Age-Related Morphological Changes In The C. Elegans Germline Stem Cell Niche

Aging Pathway

Age-related changes in the morphology of the stem cell niche in C. elegans, specifically the distal tip cell, are surprisingly regulated by signals originating from the body wall muscle, rather than solely within the niche itself, through insulin-like signaling pathways.

Nov 5, 2025
Gemini
 

Protein Catabolites As Blood-Based Biomarkers Of Aging Physiology: Findings From The Dog Aging Project

Analytical

A study using data from the Dog Aging Project identified specific protein breakdown products in the blood, called post-translationally modified amino acids, as reliable indicators of aging in dogs, with kidney function mediating about half of their age-related increase.

Nov 5, 2025
Gemini
 

Recombinant Type I & III Chimeric Collagen Significantly Enhances The Vitality Of Fibroblasts And Decelerates The Skin Aging Process

Therapeutic

A newly developed dual-function recombinant collagen, combining elements of type I and type III collagens, effectively boosts skin cell activity and reduces visible signs of aging.

Nov 5, 2025
Gemini
 

Redox-Sensitive High Mobility Group Box 1 (Hmgb1) Is A Multifunctional Regulator Of Cellular Senescence, Inflammation, And Immunosuppression: Impact On The Aging Process

Aging Pathway

The protein HMGB1, which is sensitive to the cellular environment, acts as a multi-functional regulator impacting cellular aging, inflammation, and the immune system, thereby influencing the overall aging process.

Nov 5, 2025
Gemini
 

Sirt1-Mediated Mitochondrial Homeostasis In Cardiac Aging: Molecular Mechanisms And Therapeutic Implications

Aging Pathway
Therapeutic

SIRT1 plays a crucial role in maintaining healthy mitochondria within heart cells, which is essential for counteracting the effects of aging on the heart and may offer new avenues for treating age-related heart conditions.

Nov 5, 2025
Gemini
 

Stem Cell-Free Therapy For Healthy Brain Aging: Mechanisms, Challenges, And Prospects

Therapeutic
Aging Pathway

A new approach to combat brain aging involves utilizing beneficial substances released by stem cells, rather than the cells themselves, to promote brain health and regeneration with potentially fewer risks.

Nov 5, 2025
Gemini
 

Tissue And Cellular Spatiotemporal Dynamics In Colon Aging

Aging Pathway
Analytical

Researchers have created a detailed map showing how the cells and tissues of the colon change over time and across different regions as it ages.

Nov 5, 2025
Gemini
 

Two-Phase Model Of Ageing In Mice For Improved Identification Of Age-Related And Late Life Metabolic Decline

Aging Theory

A study in mice reveals a two-phase aging process where a distinct set of physiological and metabolic changes indicates the final stage of life, independent of an individual’s actual age.

Nov 5, 2025
Gemini
 

An Ad Libitum-Fed Diet That Matches The Beneficial Lifespan Effects Of Caloric Restriction But Acts Via Opposite Effects On The Energy-Splicing Axis

Lever

A new study in mice found that a specific low-protein, high-carbohydrate diet, consumed without restriction, extends lifespan and improves metabolic health similarly to caloric restriction, but through distinct cellular mechanisms.

Nov 4, 2025
Gemini
 

Angiopoietin-Like 8 Governs Osteoblast-Adipocyte Lineage Commitment During Skeletal Aging

Aging Pathway

A protein called Angiopoietin-like 8 (ANGPTL8) promotes the formation of fat cells over bone cells from stem cells in the bone marrow during aging, contributing to age-related bone loss and increased bone marrow fat.

Nov 4, 2025
Gemini
 

Antagonistic Regulation Of LINE-1/Alu Elements And Their Repressor Apobec3B In Cellular Senescence

Aging Pathway

Reduced levels of the protein APOBEC3B in aging cells lead to increased activity of mobile genetic elements, contributing to DNA damage and the aging process.

Nov 4, 2025
Gemini
 

Assortative Breeding Experiment In A Songbird Suggests Telomere Length Is Determined During Early Life Rather Than At Conception

Clock

A study on songbirds suggests that an individual’s initial telomere length is established during early development, specifically around hatching, rather than being set at the moment of conception.

Nov 4, 2025
Gemini
 

Comparing Loss Of Individual Fragile X Proteins Suggests Strong Links To Cellular Senescence And Aging

Aging Pathway

The absence of individual fragile X proteins is significantly linked to cellular aging and the process by which cells permanently stop dividing.

Nov 4, 2025
Gemini
 

Different Gametogenesis States Uniquely Impact Longevity In Caenorhabditis Elegans

Aging Pathway

Disrupting the reproductive system in different ways in the tiny worm C. elegans leads to varied impacts on their lifespan, even when all the worms accumulate extra fat.

Nov 4, 2025
Gemini
 

Environmental Chemical Factors Associated With Human Biological Age Acceleration: An Interpretable Machine Learning Study

Clock
Analytical

An interpretable machine learning study identified specific environmental chemicals like blood toluene, a urinary benzene metabolite, and urinary benzophenone-3 as key contributors to an accelerated biological aging process in humans.

Nov 4, 2025
Gemini
 

Genistein Ameliorates Glucose-Induced Β-Amyloid Toxicity, Oxidative Stress, And Aging In The C. Elegans Model Of Alzheimer’S Disease

Lever
Therapeutic

Genistein, a compound derived from soy, was observed to extend lifespan and reduce symptoms resembling Alzheimer’s disease in a C. elegans model, by addressing toxicity caused by a specific protein accumulation, cellular damage from unstable molecules, and aspects of aging linked to high glucose levels.

Nov 4, 2025
Gemini
 

Immunosenescence: Shaping The Hematological Narrative In The Era Of Aging

The aging of the immune system, known as immunosenescence, plays a crucial role in shaping the development and progression of various blood-related disorders, impacting both disease risk and the effectiveness of treatments.

Nov 4, 2025
Gemini
 

O304 Is A Mitochondrial Uncoupler Which Extends C. Elegans Lifespan And Induces Vasorelaxation Of Rat Mesenteric Arteries

Lever
Therapeutic

A compound designated O304 has been found to extend the lifespan of C. elegans worms and relax rat blood vessels by acting as a mitochondrial uncoupler.

Nov 4, 2025
Gemini
 

Obstructive Sleep Apnea And Aging Of The Cardiovascular System: A Multidimensional Analysis Of The Mechanisms Involved

Aging Pathway

Obstructive sleep apnea accelerates the aging of the cardiovascular system through multiple pathways, including cellular senescence, mitochondrial dysfunction, metabolic dysregulation, telomere attrition, impaired intercellular communication, and adipose tissue senescence.

Nov 4, 2025
Gemini
 

P-Selectin Overexpression Impairs Hematopoietic Stem Cell Homeostasis Via Inflammatory Receptor-Mediated Proliferation And Differentiation

Aging Pathway

Overexpression of P-selectin impairs the ability of hematopoietic stem cells to maintain a healthy blood and immune system by causing them to over-proliferate and differentiate prematurely, particularly during aging and inflammation, but it also shows potential to inhibit leukemia stem cells.

Nov 4, 2025
Gemini
 

Phenotypes, Mechanisms, And Therapeutic Strategies Of Natural Killer Cell Immunosenescence

Therapeutic

This paper reviews the characteristics, underlying processes, and potential treatments for the age-related decline in function of natural killer immune cells, which are crucial for fighting infections and tumors.

Nov 4, 2025
Gemini
 

Profile Of Biological Aging In First Primary Cancers: A Pan-Cancer Analysis Of Two Large-Scale Cohorts From The UK And Hong Kong

Clock
Analytical

Biological aging that progresses faster than a person’s chronological age is associated with an elevated risk of developing various cancers, with a particularly strong link to lung cancer incidence and mortality.

Nov 4, 2025
Gemini
 

Reproductive Fitness And The Links To Chronic Disease And Systemic Aging

Aging Theory

Female reproductive aging is the earliest indicator of aging in humans, and reproductive health, including normal transitions and disorders, significantly influences long-term systemic health and the risk of chronic diseases.

Nov 4, 2025
Gemini
 

Single-Cell RNA Sequencing Identifies Accumulation Of Fcgr2B + Virtual Memory-Like Cd8 T Cells With Cytotoxic And Inflammatory Potential In Aged Mouse White Adipose Tissue

Aging Pathway

Single-cell RNA sequencing revealed that aging in mice leads to an accumulation of a specific type of immune cell, called Fcgr2b+ virtual memory-like CD8 T cells, within white adipose tissue, which possess the ability to cause both cell damage and inflammation.

Nov 4, 2025
Gemini
 

Spatiotemporal Transcriptomic Characteristics Of Immune And Metabolic Dysregulation During Mouse Brain Aging

A comprehensive study mapped gene activity across different mouse brain regions throughout the aging process, revealing distinct patterns of immune system activation and metabolic changes over time.

Nov 4, 2025
Gemini
 

Telomerase And Alternative Lengthening Of Telomeres Coexist In The Regenerating Zebrafish Caudal Fins

Aging Pathway

Zebrafish maintain the protective caps on their chromosomes, called telomeres, during fin regeneration through both the telomerase enzyme and an alternative repair pathway, especially when telomerase is absent.

Nov 4, 2025
Gemini
 

The Metabolic Transition Between Fasting And Feeding Alters Aging-Associated Metabolites, Lowers Bcaas, And Stimulates Fgf21 Production In Humans

Analytical
Aging Pathway

The refeeding period after a fast significantly alters metabolic markers associated with aging, decreases branched-chain amino acids, and increases the production of the hormone FGF21 in humans.

Nov 4, 2025
Gemini
 

The Multiomics Blueprint Of The Individual With The Most Extreme Lifespan

Clock
Analytical

A multiomics study of the world’s oldest living person revealed that despite exhibiting some molecular hallmarks of aging, she lacked major age-associated diseases due to resilient genetic variants, a low-inflammation metabolic profile, a rejuvenated microbiome, and a younger epigenome.

Nov 4, 2025
Gemini
 

Zc3H4, A Novel Regulator Of Mitochondrial Complex I, Impacts Prostate Stromal Cell Senescence, Attachment, Adhesion And Anoikis Resistance

Aging Pathway

Loss of the protein ZC3H4 disrupts mitochondrial function, leading to changes in prostate stromal cells that contribute to cellular aging, altered cell binding, and resistance to cell death, mimicking aspects of prostate enlargement.

Nov 4, 2025
Gemini
 

20(S)-protopanaxadiol prolongs lifespan and enhances stress resistance in Caenorhabditis elegans via the insulin/IGF-1 signaling pathway.

Aging Pathway

A compound called 20(S)-protopanaxadiol was found to extend the lifespan and improve stress resistance in Caenorhabditis elegans worms by acting on the insulin/IGF-1 signaling pathway.

Nov 3, 2025
Gemini
 

A novel miRNA-TF-mRNA regulatory network associated with cellular senescence in osteoporosis.

Aging Pathway

A newly identified genetic pathway involving a small RNA molecule and a specific gene has been found to drive the development of osteoporosis by promoting cell aging and fat accumulation while hindering bone formation.

Nov 3, 2025
Gemini
 

A receptor for glycation end products (RAGE) is a key transmitter between garb-aging and inflammaging.

Aging Pathway

The receptor for glycation end products (RAGE) acts as a crucial link connecting the accumulation of cellular waste products with the chronic inflammation observed in aging.

Nov 3, 2025
Gemini
 

Advancing Single-Cell Transcriptomic Analysis To Reveal Age-Related Skeletal Muscle Changes: A Systematic Review

Age-related changes in skeletal muscle involve alterations in cellular composition, increased inflammation, and disrupted cellular processes such as regeneration, as revealed by advanced single-cell analysis techniques.

Nov 3, 2025
Gemini
 

Age and sex influence diurnal memory oscillations, circadian rhythmicity, and Per1 expression.

Aging Pathway

Memory performance and daily body clock patterns fluctuate depending on an individual’s age and sex, with the gene Per1 playing a role in these processes.

Nov 3, 2025
Gemini
 

Age- and sex-specific transcriptomic changes drive the prothrombotic potential of megakaryocytes.

Research indicates that the cells responsible for producing platelets, called megakaryocytes, undergo distinct changes with age that vary between sexes, influencing the risk of blood clot formation.

Nov 3, 2025
Gemini
 

Aging-rewired metabolic cues promote autophagy and senescence via DRAM1.

Aging Pathway

The study reveals that metabolic changes associated with aging, specifically the buildup of N-acetylhistamine and phosphatidylethanolamine, promote a specialized form of autophagy involving the protein DRAM1, which contributes to cellular aging and senescence.

Nov 3, 2025
Gemini
 

Association Of Biological Age Acceleration With All-Cause And Cardiovascular Mortality In HSV-Positive Adults: A Population-Based Longitudinal Cohort Study

Clock
Analytical

Individuals infected with the herpes simplex virus who show signs of accelerated biological aging face a higher risk of death from all causes and cardiovascular disease.

Nov 3, 2025
Gemini
 

Atorvastatin Ameliorates Cerebral Cortical Pathological And Cognitive Alterations In Aged Rats: Histological & Immunohistochemical Study

Therapeutic
Lever

Atorvastatin demonstrated a neuroprotective effect in aged rats by improving memory function and reducing age-related brain changes through the regulation of oxidative stress, inflammation, apoptosis, and cellular cleanup processes.

Nov 3, 2025
Gemini
 

Characterization of the Intact Proteomic Profile of Senescent-Associated Secretory Phenotype by Top-Down Mass Spectrometry.

Researchers have used an advanced proteomic technique to identify previously unknown intact protein forms and their modifications in the secretions of senescent cells, including potential new biomarkers for aging.

Nov 3, 2025
Gemini
 

Correlations between Aging, Telomeres, and Natural Compounds.

The paper investigates the intricate relationship between the aging process, the protective caps on chromosomes called telomeres, and the potential therapeutic effects of various natural compounds in promoting a longer and healthier life by influencing age-related cellular pathways.

Nov 3, 2025
Gemini
 

Embryonic stem cell-derived extracellular vesicles delay cellular senescence by inhibiting oxidative stress.

Lever

Embryonic stem cell-derived extracellular vesicles can delay the aging of cells by inhibiting oxidative stress, a process that damages cells.

Nov 3, 2025
Gemini
 

High-fat diet attenuates vestibular and auditory dysfunction in aged mice via macrophage-mediated anti-inflammatory mechanisms.

Lever
Aging Pathway

A high-fat diet was found to slow down the decline of both balance and hearing abilities in aged mice by promoting immune cells that reduce inflammation.

Nov 3, 2025
Gemini
 

Increase of brain Aβ peptides and secretase activity during normal aging in rodent and human.

Aging Pathway

Normal aging leads to an increase in amyloid beta protein fragments and the activity of a specific enzyme called beta-secretase in the brains of rodents and humans.

Nov 3, 2025
Gemini
 

Inflammaging and Senescence-Driven Extracellular Matrix Remodeling in Age-Associated Cardiovascular Disease.

Aging Pathway

Chronic low-grade inflammation and the accumulation of senescent cells are key drivers of detrimental structural changes in the heart and blood vessels, contributing significantly to age-associated cardiovascular diseases.

Nov 3, 2025
Gemini
 

LCN2 promotes HEI-OC1 cells senescence via activating NF-κB signal pathway in presbycusis.

Aging Pathway

A study found that a protein called LCN2 promotes the aging of inner ear cells by activating a specific signaling pathway, contributing to age-related hearing loss.

Nov 3, 2025
Gemini
 

Near infrared LED irradiation reverses the declining quality of mice post-ovulatory aging and reproductive aged oocytes†.

Lever

Near-infrared LED light exposure has been shown to improve the quality of aged mouse egg cells by revitalizing their cellular energy powerhouses.

Nov 3, 2025
Gemini
 

Revealing the Interplay of Intraorganellar O2•- and ATP in Brain Aging-Related Alzheimer’s Disease via Unimolecular Dual-Responsive Probes.

Researchers developed tools to observe the interplay of a damaging molecule called superoxide and the cell’s energy currency, ATP, within brain cell compartments, finding that aging cells affected by Alzheimer’s-related proteins experience an imbalance where damaging superoxide increases before ATP decreases.

Nov 3, 2025
Gemini
 

Sirolimus Use In Allogeneic Hematopoietic Cell Transplant Recipients: Assessing Its Senotherapeutic Role In A High Risk Population

Analytical
Therapeutic

The study investigated whether sirolimus, when used at standard doses to prevent complications after allogeneic hematopoietic cell transplantation, demonstrates a significant anti-aging effect by reducing cellular senescence.

Nov 3, 2025
Gemini
 

Targeting Genome Stability to Mitigate Human Aging and Disease.

Maintaining the stability of our genetic material is crucial for healthy aging and disease prevention, with strategies focusing on DNA repair and managing cellular responses to damage.

Nov 3, 2025
Gemini
 

Vitamin C conveys geroprotection on primate ovaries.

Lever
Therapeutic

A long-term study in monkeys demonstrated that regular oral vitamin C intake can slow down the aging process of their ovaries.

Nov 3, 2025
Gemini
 

Empagliflozin slows down natural kidney senescence via Six1/Wnt4/NF-κB pathway.

Therapeutic
Lever

A medication called empagliflozin has been shown to slow down the natural aging process in kidneys by targeting specific molecular pathways.

Nov 2, 2025
Gemini
 

Enhancing the Anti-Aging Potential of Green Tea Extracts Through Liquid-State Fermentation with Aspergillus niger RAF106.

Lever
Therapeutic

Liquid-state fermentation of green tea extracts with the fungus Aspergillus niger RAF106 significantly boosts their anti-aging capabilities, leading to an extended lifespan and improved health indicators in a model organism.

Nov 2, 2025
Gemini
 

Molecular Framework of the Onset and Progression of Skeletal Muscle Aging.

Aging Theory

Skeletal muscle aging commences during middle age with subtle molecular alterations, preceding the noticeable loss of muscle mass and function.

Nov 2, 2025
Gemini
 

Welcome To Aging Papers

This website will host summaries of the most recent scientific papers published about aging. It will be updated daily.
Oct 26, 2025
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